Treatment compliance of patients with paracoccidioidomycosis in Central-West Brazil

ABSTRACT Objective: To evaluate the treatment compliance of patients with paracoccidioidomycosis. Methods: We studied 188 patients with paracoccidioidomycosis admitted to a tertiary referral hospital in the Central-West Region of Brazil from 2000 to 2010, to assess their compliance to treatment. In order to be considered compliant, patients needed to present two established criteria: (1) receive medicines from the pharmacy, and (2) achieve a self-reported utilization of at least 80% of the dispensed antifungal compounds prescribed since their previous appointment. Results: Most patients were male (95.7%), had the chronic form of the disease (94.2%), and were treated with cotrimoxazole (86.2%). Only 44.6% of patients were treatment compliant. The highest loss to follow-up was observed in the first 4 months of treatment (p < 0.02). Treatment compliance was higher for patients with than for those without pulmonary involvement (OR: 2.986; 95%CI 1.351-6.599), and higher for patients with than without tuberculosis as co-morbidity (OR: 2.763; 95%CI 1.004-7.604). Conclusions: Compliance to paracoccidioidomycosis treatment was low, and the period with the highest loss to follow-up corresponds to the first four months. Pulmonary paracoccidioidal involvement or tuberculosis comorbidity predicts a higher compliance to paracoccidioidomycosis therapy.

Bibliographic Details

Main Authors:	Andrade,Ursulla Vilella, Oliveira,Sandra Maria do Valle Leone de, Chang,Marilene Rodrigues, Pereira,Edy Firmina, Marques,Ana Paula da Costa, Carvalho,Lidia Raquel de, Mendes,Rinaldo Poncio, Paniago,Anamaria Mello Miranda
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Pneumologia e Tisiologia 2019
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1806-37132019000200202
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