The silent killer: myocardial injury after non-cardiac surgery (MINS)
INTRODUCTION: Recent work into the causes of death after non-cardiac surgery has identified a new clinical concept, namely myocardial injury after non-cardiac surgery (MINS). The pathophysiology is related to a supply-and-demand mismatch in the peri-operative period and differs from the traditional model of myocardial ischaemia and infarction. METHODS: Literature review of current body of knowledge and recent large multicentre clinical trials. RESULTS: MINS is associated with increased morbidity and mortality at 30 days' post-surgery. A large international multicentre trial found that a troponin T level of greater than 0.3 ng/ml was associated with a mortality rate of 16.9%. Moreover, 84.2% of MINS would probably go undetected if systematic troponin monitoring after surgery was not performed CONCLUSION: This review examines the current body of knowledge and provides practical guidelines on how to identify and manage patients with MINS. LEVEL OF EVIDENCE: Level 5.
Main Authors: | , , |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Medpharm Publications
2018
|
Online Access: | http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S1681-150X2018000200002 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
oai:scielo:S1681-150X2018000200002 |
---|---|
record_format |
ojs |
spelling |
oai:scielo:S1681-150X20180002000022018-10-03The silent killer: myocardial injury after non-cardiac surgery (MINS)Simpson,GCMarais,LCRodseth,RN MINS myocardial injury after non-cardiac surgery troponin elevation peri-operative myocardial injury myocardial ischaemia INTRODUCTION: Recent work into the causes of death after non-cardiac surgery has identified a new clinical concept, namely myocardial injury after non-cardiac surgery (MINS). The pathophysiology is related to a supply-and-demand mismatch in the peri-operative period and differs from the traditional model of myocardial ischaemia and infarction. METHODS: Literature review of current body of knowledge and recent large multicentre clinical trials. RESULTS: MINS is associated with increased morbidity and mortality at 30 days' post-surgery. A large international multicentre trial found that a troponin T level of greater than 0.3 ng/ml was associated with a mortality rate of 16.9%. Moreover, 84.2% of MINS would probably go undetected if systematic troponin monitoring after surgery was not performed CONCLUSION: This review examines the current body of knowledge and provides practical guidelines on how to identify and manage patients with MINS. LEVEL OF EVIDENCE: Level 5.Medpharm PublicationsSA Orthopaedic Journal v.17 n.2 20182018-06-01journal articletext/htmlhttp://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S1681-150X2018000200002en |
institution |
SCIELO |
collection |
OJS |
country |
Sudáfrica |
countrycode |
ZA |
component |
Revista |
access |
En linea |
databasecode |
rev-scielo-za |
tag |
revista |
region |
África del Sur |
libraryname |
SciELO |
language |
English |
format |
Digital |
author |
Simpson,GC Marais,LC Rodseth,RN |
spellingShingle |
Simpson,GC Marais,LC Rodseth,RN The silent killer: myocardial injury after non-cardiac surgery (MINS) |
author_facet |
Simpson,GC Marais,LC Rodseth,RN |
author_sort |
Simpson,GC |
title |
The silent killer: myocardial injury after non-cardiac surgery (MINS) |
title_short |
The silent killer: myocardial injury after non-cardiac surgery (MINS) |
title_full |
The silent killer: myocardial injury after non-cardiac surgery (MINS) |
title_fullStr |
The silent killer: myocardial injury after non-cardiac surgery (MINS) |
title_full_unstemmed |
The silent killer: myocardial injury after non-cardiac surgery (MINS) |
title_sort |
silent killer: myocardial injury after non-cardiac surgery (mins) |
description |
INTRODUCTION: Recent work into the causes of death after non-cardiac surgery has identified a new clinical concept, namely myocardial injury after non-cardiac surgery (MINS). The pathophysiology is related to a supply-and-demand mismatch in the peri-operative period and differs from the traditional model of myocardial ischaemia and infarction. METHODS: Literature review of current body of knowledge and recent large multicentre clinical trials. RESULTS: MINS is associated with increased morbidity and mortality at 30 days' post-surgery. A large international multicentre trial found that a troponin T level of greater than 0.3 ng/ml was associated with a mortality rate of 16.9%. Moreover, 84.2% of MINS would probably go undetected if systematic troponin monitoring after surgery was not performed CONCLUSION: This review examines the current body of knowledge and provides practical guidelines on how to identify and manage patients with MINS. LEVEL OF EVIDENCE: Level 5. |
publisher |
Medpharm Publications |
publishDate |
2018 |
url |
http://www.scielo.org.za/scielo.php?script=sci_arttext&pid=S1681-150X2018000200002 |
work_keys_str_mv |
AT simpsongc thesilentkillermyocardialinjuryafternoncardiacsurgerymins AT maraislc thesilentkillermyocardialinjuryafternoncardiacsurgerymins AT rodsethrn thesilentkillermyocardialinjuryafternoncardiacsurgerymins AT simpsongc silentkillermyocardialinjuryafternoncardiacsurgerymins AT maraislc silentkillermyocardialinjuryafternoncardiacsurgerymins AT rodsethrn silentkillermyocardialinjuryafternoncardiacsurgerymins |
_version_ |
1756007380877836288 |