Factors associated with multidrug-resistant bacteria in healthcare-associated infections: a pediatric intensive care unit case-control study
ABSTRACT Objective To investigate the prevalence of factors related to healthcare-associated infections, caused by multidrug-resistant bacteria, in a pediatric intensive care unit. Methods A retrospective case-control study conducted from January 1, 2007 to December 31, 2018, in São Paulo (SP), Brazil. The study was carried out at the pediatric intensive care unit of a high-complexity, tertiary care general hospital. The study included patients aged 1 month to 19 years, admitted to the pediatric intensive care unit, diagnosed as healthcare-associated infections. Results There was significant evidence of infection by multidrug-resistant bacteria associated with immunosuppressed patients (p<0.001), in whom the likelihood of multidrug-resistant bacteria infection was estimated to be nine-fold higher than among non-immunosuppressed patients (OR 8.97; 95%CI 2.69-29.94). In the analysis of multiple logistic regression model, we observed that immunosuppressed patients had an 8.5-fold higher chance of multidrug-resistant bacteria infection when compared to non-immunosuppressed patients (OR 8.48; 95%CI 2.54-28.35; p=0.001). There is evidence of association between the Case Group and presence of Gram-positive (p=0.007), coagulase-negative Staphylococcus (p<0.001), and Gram-negative (p=0.041) microorganisms. Conclusion The immunocompromised-state variable is a factor related to healthcare-associated infections caused by multidrug-resistant bacteria, and the Case Group presented higher proportions of Gram-positive microorganisms and coagulase-negative Staphylococcus.
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Instituto Israelita de Ensino e Pesquisa Albert Einstein
2022
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oai:scielo:S1679-450820220001002322022-04-19Factors associated with multidrug-resistant bacteria in healthcare-associated infections: a pediatric intensive care unit case-control studySilva,Barbara Barduchi Oliveira daSilva Júnior,MoacyrMenezes,Fernando Gatti deTroster,Eduardo Juan Drug resistance, multiple, bacterial Intensive care units, pediatric Risk factors Cross infection ABSTRACT Objective To investigate the prevalence of factors related to healthcare-associated infections, caused by multidrug-resistant bacteria, in a pediatric intensive care unit. Methods A retrospective case-control study conducted from January 1, 2007 to December 31, 2018, in São Paulo (SP), Brazil. The study was carried out at the pediatric intensive care unit of a high-complexity, tertiary care general hospital. The study included patients aged 1 month to 19 years, admitted to the pediatric intensive care unit, diagnosed as healthcare-associated infections. Results There was significant evidence of infection by multidrug-resistant bacteria associated with immunosuppressed patients (p<0.001), in whom the likelihood of multidrug-resistant bacteria infection was estimated to be nine-fold higher than among non-immunosuppressed patients (OR 8.97; 95%CI 2.69-29.94). In the analysis of multiple logistic regression model, we observed that immunosuppressed patients had an 8.5-fold higher chance of multidrug-resistant bacteria infection when compared to non-immunosuppressed patients (OR 8.48; 95%CI 2.54-28.35; p=0.001). There is evidence of association between the Case Group and presence of Gram-positive (p=0.007), coagulase-negative Staphylococcus (p<0.001), and Gram-negative (p=0.041) microorganisms. Conclusion The immunocompromised-state variable is a factor related to healthcare-associated infections caused by multidrug-resistant bacteria, and the Case Group presented higher proportions of Gram-positive microorganisms and coagulase-negative Staphylococcus.info:eu-repo/semantics/openAccessInstituto Israelita de Ensino e Pesquisa Albert Einsteineinstein (São Paulo) v.20 20222022-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082022000100232en10.31744/einstein_journal/2022ao6704 |
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Silva,Barbara Barduchi Oliveira da Silva Júnior,Moacyr Menezes,Fernando Gatti de Troster,Eduardo Juan |
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Silva,Barbara Barduchi Oliveira da Silva Júnior,Moacyr Menezes,Fernando Gatti de Troster,Eduardo Juan Factors associated with multidrug-resistant bacteria in healthcare-associated infections: a pediatric intensive care unit case-control study |
author_facet |
Silva,Barbara Barduchi Oliveira da Silva Júnior,Moacyr Menezes,Fernando Gatti de Troster,Eduardo Juan |
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Silva,Barbara Barduchi Oliveira da |
title |
Factors associated with multidrug-resistant bacteria in healthcare-associated infections: a pediatric intensive care unit case-control study |
title_short |
Factors associated with multidrug-resistant bacteria in healthcare-associated infections: a pediatric intensive care unit case-control study |
title_full |
Factors associated with multidrug-resistant bacteria in healthcare-associated infections: a pediatric intensive care unit case-control study |
title_fullStr |
Factors associated with multidrug-resistant bacteria in healthcare-associated infections: a pediatric intensive care unit case-control study |
title_full_unstemmed |
Factors associated with multidrug-resistant bacteria in healthcare-associated infections: a pediatric intensive care unit case-control study |
title_sort |
factors associated with multidrug-resistant bacteria in healthcare-associated infections: a pediatric intensive care unit case-control study |
description |
ABSTRACT Objective To investigate the prevalence of factors related to healthcare-associated infections, caused by multidrug-resistant bacteria, in a pediatric intensive care unit. Methods A retrospective case-control study conducted from January 1, 2007 to December 31, 2018, in São Paulo (SP), Brazil. The study was carried out at the pediatric intensive care unit of a high-complexity, tertiary care general hospital. The study included patients aged 1 month to 19 years, admitted to the pediatric intensive care unit, diagnosed as healthcare-associated infections. Results There was significant evidence of infection by multidrug-resistant bacteria associated with immunosuppressed patients (p<0.001), in whom the likelihood of multidrug-resistant bacteria infection was estimated to be nine-fold higher than among non-immunosuppressed patients (OR 8.97; 95%CI 2.69-29.94). In the analysis of multiple logistic regression model, we observed that immunosuppressed patients had an 8.5-fold higher chance of multidrug-resistant bacteria infection when compared to non-immunosuppressed patients (OR 8.48; 95%CI 2.54-28.35; p=0.001). There is evidence of association between the Case Group and presence of Gram-positive (p=0.007), coagulase-negative Staphylococcus (p<0.001), and Gram-negative (p=0.041) microorganisms. Conclusion The immunocompromised-state variable is a factor related to healthcare-associated infections caused by multidrug-resistant bacteria, and the Case Group presented higher proportions of Gram-positive microorganisms and coagulase-negative Staphylococcus. |
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Instituto Israelita de Ensino e Pesquisa Albert Einstein |
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2022 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082022000100232 |
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