Heart transplantation: review
ABSTRACT Heart transplantation is currently the definitive gold standard surgical approach in the treatment of refractory heart failure. However, the shortage of donors limits the achievement of a greater number of heart transplants, in which the use of mechanical circulatory support devices is increasing. With well-established indications and contraindications, as well as diagnosis and treatment of rejection through defined protocols of immunosuppression, the outcomes of heart transplantation are very favorable. Among early complications that can impact survival are primary graft failure, right ventricular dysfunction, rejection, and infections, whereas late complications include cardiac allograft vasculopathy and neoplasms. Despite the difficulties for heart transplantation, in particular, the shortage of donors and high mortality while on the waiting list, in Brazil, there is a great potential for both increasing effective donors and using circulatory assist devices, which can positively impact the number and outcomes of heart transplants.
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Instituto Israelita de Ensino e Pesquisa Albert Einstein
2015
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oai:scielo:S1679-450820150002000252015-12-03Heart transplantation: reviewMangini,SandrigoAlves,Bárbara RubimSilvestre,Odílson MarcosPires,Philippe VieiraPires,Lucas José TachottiCuriati,Milena Novaes CardosoBacal,Fernando Heart transplantation Heart transplantation/adverse effects Infections Graft rejection ABSTRACT Heart transplantation is currently the definitive gold standard surgical approach in the treatment of refractory heart failure. However, the shortage of donors limits the achievement of a greater number of heart transplants, in which the use of mechanical circulatory support devices is increasing. With well-established indications and contraindications, as well as diagnosis and treatment of rejection through defined protocols of immunosuppression, the outcomes of heart transplantation are very favorable. Among early complications that can impact survival are primary graft failure, right ventricular dysfunction, rejection, and infections, whereas late complications include cardiac allograft vasculopathy and neoplasms. Despite the difficulties for heart transplantation, in particular, the shortage of donors and high mortality while on the waiting list, in Brazil, there is a great potential for both increasing effective donors and using circulatory assist devices, which can positively impact the number and outcomes of heart transplants.info:eu-repo/semantics/openAccessInstituto Israelita de Ensino e Pesquisa Albert Einsteineinstein (São Paulo) v.13 n.2 20152015-06-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082015000200025en10.1590/S1679-45082015RW3154 |
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Mangini,Sandrigo Alves,Bárbara Rubim Silvestre,Odílson Marcos Pires,Philippe Vieira Pires,Lucas José Tachotti Curiati,Milena Novaes Cardoso Bacal,Fernando |
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Mangini,Sandrigo Alves,Bárbara Rubim Silvestre,Odílson Marcos Pires,Philippe Vieira Pires,Lucas José Tachotti Curiati,Milena Novaes Cardoso Bacal,Fernando Heart transplantation: review |
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Mangini,Sandrigo Alves,Bárbara Rubim Silvestre,Odílson Marcos Pires,Philippe Vieira Pires,Lucas José Tachotti Curiati,Milena Novaes Cardoso Bacal,Fernando |
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Mangini,Sandrigo |
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Heart transplantation: review |
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Heart transplantation: review |
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Heart transplantation: review |
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Heart transplantation: review |
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Heart transplantation: review |
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heart transplantation: review |
description |
ABSTRACT Heart transplantation is currently the definitive gold standard surgical approach in the treatment of refractory heart failure. However, the shortage of donors limits the achievement of a greater number of heart transplants, in which the use of mechanical circulatory support devices is increasing. With well-established indications and contraindications, as well as diagnosis and treatment of rejection through defined protocols of immunosuppression, the outcomes of heart transplantation are very favorable. Among early complications that can impact survival are primary graft failure, right ventricular dysfunction, rejection, and infections, whereas late complications include cardiac allograft vasculopathy and neoplasms. Despite the difficulties for heart transplantation, in particular, the shortage of donors and high mortality while on the waiting list, in Brazil, there is a great potential for both increasing effective donors and using circulatory assist devices, which can positively impact the number and outcomes of heart transplants. |
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Instituto Israelita de Ensino e Pesquisa Albert Einstein |
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2015 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1679-45082015000200025 |
work_keys_str_mv |
AT manginisandrigo hearttransplantationreview AT alvesbarbararubim hearttransplantationreview AT silvestreodilsonmarcos hearttransplantationreview AT piresphilippevieira hearttransplantationreview AT pireslucasjosetachotti hearttransplantationreview AT curiatimilenanovaescardoso hearttransplantationreview AT bacalfernando hearttransplantationreview |
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