A review on the Scorpaena plumieri fish venom and its bioactive compounds

Abstract The most poisonous fish species found along the Brazilian coast is the spotted scorpionfish Scorpaena plumieri. Though hardly ever life-threatening to humans, envenomation by S. plumieri can be quite hazardous, provoking extreme pain and imposing significant socioeconomic costs, as the victims may require days to weeks to recover from their injuries. In this review we will walk the reader through the biological features that distinguish this species as well as the current epidemiological knowledge related to the envenomation and its consequences. But above all, we will discuss the challenges involved in the biochemical characterization of the S. plumieri venom and its compounds, focusing then on the successful isolation and pharmacological analysis of some of the bioactive molecules responsible for the effects observed upon envenomation as well as on experimental models. Despite the achievement of considerable progress, much remains to be done, particularly in relation to the non-proteinaceous components of the venom. Therefore, further studies are necessary in order to provide a more complete picture of the venom’s chemical composition and physiological effects. Given that fish venoms remain considerably less studied when compared to terrestrial venoms, the exploration of their full potential opens a myriad of possibilities for the development of new drug leads and tools for elucidating the complex physiological processes.

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Main Authors: Campos,Fabiana V., Menezes,Thiago N., Malacarne,Pedro F., Costa,Fábio L. S., Naumann,Gustavo B., Gomes,Helena L., Figueiredo,Suely G.
Format: Digital revista
Language:English
Published: Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP) 2016
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100205
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spelling oai:scielo:S1678-919920160001002052017-01-16A review on the Scorpaena plumieri fish venom and its bioactive compoundsCampos,Fabiana V.Menezes,Thiago N.Malacarne,Pedro F.Costa,Fábio L. S.Naumann,Gustavo B.Gomes,Helena L.Figueiredo,Suely G. Scorpionfish Scorpaena plumieri venom Inflammatory response Proteolytic activity Cardiovascular activity Sp-GP Plumieribetin C-type lectins Sp-CTx Abstract The most poisonous fish species found along the Brazilian coast is the spotted scorpionfish Scorpaena plumieri. Though hardly ever life-threatening to humans, envenomation by S. plumieri can be quite hazardous, provoking extreme pain and imposing significant socioeconomic costs, as the victims may require days to weeks to recover from their injuries. In this review we will walk the reader through the biological features that distinguish this species as well as the current epidemiological knowledge related to the envenomation and its consequences. But above all, we will discuss the challenges involved in the biochemical characterization of the S. plumieri venom and its compounds, focusing then on the successful isolation and pharmacological analysis of some of the bioactive molecules responsible for the effects observed upon envenomation as well as on experimental models. Despite the achievement of considerable progress, much remains to be done, particularly in relation to the non-proteinaceous components of the venom. Therefore, further studies are necessary in order to provide a more complete picture of the venom’s chemical composition and physiological effects. Given that fish venoms remain considerably less studied when compared to terrestrial venoms, the exploration of their full potential opens a myriad of possibilities for the development of new drug leads and tools for elucidating the complex physiological processes.info:eu-repo/semantics/openAccessCentro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)Journal of Venomous Animals and Toxins including Tropical Diseases v.22 20162016-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100205en10.1186/s40409-016-0090-7
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language English
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author Campos,Fabiana V.
Menezes,Thiago N.
Malacarne,Pedro F.
Costa,Fábio L. S.
Naumann,Gustavo B.
Gomes,Helena L.
Figueiredo,Suely G.
spellingShingle Campos,Fabiana V.
Menezes,Thiago N.
Malacarne,Pedro F.
Costa,Fábio L. S.
Naumann,Gustavo B.
Gomes,Helena L.
Figueiredo,Suely G.
A review on the Scorpaena plumieri fish venom and its bioactive compounds
author_facet Campos,Fabiana V.
Menezes,Thiago N.
Malacarne,Pedro F.
Costa,Fábio L. S.
Naumann,Gustavo B.
Gomes,Helena L.
Figueiredo,Suely G.
author_sort Campos,Fabiana V.
title A review on the Scorpaena plumieri fish venom and its bioactive compounds
title_short A review on the Scorpaena plumieri fish venom and its bioactive compounds
title_full A review on the Scorpaena plumieri fish venom and its bioactive compounds
title_fullStr A review on the Scorpaena plumieri fish venom and its bioactive compounds
title_full_unstemmed A review on the Scorpaena plumieri fish venom and its bioactive compounds
title_sort review on the scorpaena plumieri fish venom and its bioactive compounds
description Abstract The most poisonous fish species found along the Brazilian coast is the spotted scorpionfish Scorpaena plumieri. Though hardly ever life-threatening to humans, envenomation by S. plumieri can be quite hazardous, provoking extreme pain and imposing significant socioeconomic costs, as the victims may require days to weeks to recover from their injuries. In this review we will walk the reader through the biological features that distinguish this species as well as the current epidemiological knowledge related to the envenomation and its consequences. But above all, we will discuss the challenges involved in the biochemical characterization of the S. plumieri venom and its compounds, focusing then on the successful isolation and pharmacological analysis of some of the bioactive molecules responsible for the effects observed upon envenomation as well as on experimental models. Despite the achievement of considerable progress, much remains to be done, particularly in relation to the non-proteinaceous components of the venom. Therefore, further studies are necessary in order to provide a more complete picture of the venom’s chemical composition and physiological effects. Given that fish venoms remain considerably less studied when compared to terrestrial venoms, the exploration of their full potential opens a myriad of possibilities for the development of new drug leads and tools for elucidating the complex physiological processes.
publisher Centro de Estudos de Venenos e Animais Peçonhentos (CEVAP/UNESP)
publishDate 2016
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992016000100205
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