Local application of statins in the treatment of experimental periodontal disease in rats
Abstract Objective The objective of this study was to evaluate the local effects of statins as adjuvants for treatment by scaling and root planing (SRP) of periodontal disease induced in rats. Material and Methods Ninety rats were used in the present experiment. Periodontal disease was induced in all animals using a cotton thread placed in the left first mandibular molar. After 7 days of induction, the bandage was removed and the animals were divided into three groups: 1) NT group (n=30), no treatment; 2) SRP group (n=30): SRP and irrigation with control gel; 3) S group (n=30) - SRP and irrigation with Simvastatin. Ten animals from each group were euthanized at 7, 15 and 30 days after treatment. Gingival biopsy specimens were processed to analyze the expression of matrix metalloproteinase 8 (MMP-8). The mandibles were removed and submitted to radiographic and laboratory processing for histometric analysis. Results The S group showed a significantly lower expression of MMP-8 compared to NT and SRP groups in all experimental periods. In the radiographic and histometric analyses between the groups, S group showed a significantly lower bone loss (BL) compared to NT and SRP groups in all experimental periods. Conclusions Within the limits of this study, it can be concluded that locally applied statin was effective as an adjuvant treatment for SRP in rats with induced periodontal disease.
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Faculdade De Odontologia De Bauru - USP
2017
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oai:scielo:S1678-775720170002001682017-06-26Local application of statins in the treatment of experimental periodontal disease in ratsSANTOS,Bianca Fernanda EspósitoSOUZA,Eduardo Quintão ManhaniniBRIGAGÃO,Maísa Ribeiro Pereira LimaLIMA,Daniela Coelho deFERNANDES,Leandro Araújo Periodontitis Alveolar bone loss Simvastatin Abstract Objective The objective of this study was to evaluate the local effects of statins as adjuvants for treatment by scaling and root planing (SRP) of periodontal disease induced in rats. Material and Methods Ninety rats were used in the present experiment. Periodontal disease was induced in all animals using a cotton thread placed in the left first mandibular molar. After 7 days of induction, the bandage was removed and the animals were divided into three groups: 1) NT group (n=30), no treatment; 2) SRP group (n=30): SRP and irrigation with control gel; 3) S group (n=30) - SRP and irrigation with Simvastatin. Ten animals from each group were euthanized at 7, 15 and 30 days after treatment. Gingival biopsy specimens were processed to analyze the expression of matrix metalloproteinase 8 (MMP-8). The mandibles were removed and submitted to radiographic and laboratory processing for histometric analysis. Results The S group showed a significantly lower expression of MMP-8 compared to NT and SRP groups in all experimental periods. In the radiographic and histometric analyses between the groups, S group showed a significantly lower bone loss (BL) compared to NT and SRP groups in all experimental periods. Conclusions Within the limits of this study, it can be concluded that locally applied statin was effective as an adjuvant treatment for SRP in rats with induced periodontal disease.info:eu-repo/semantics/openAccessFaculdade De Odontologia De Bauru - USPJournal of Applied Oral Science v.25 n.2 20172017-04-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572017000200168en10.1590/1678-77572016-0149 |
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SANTOS,Bianca Fernanda Espósito SOUZA,Eduardo Quintão Manhanini BRIGAGÃO,Maísa Ribeiro Pereira Lima LIMA,Daniela Coelho de FERNANDES,Leandro Araújo |
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SANTOS,Bianca Fernanda Espósito SOUZA,Eduardo Quintão Manhanini BRIGAGÃO,Maísa Ribeiro Pereira Lima LIMA,Daniela Coelho de FERNANDES,Leandro Araújo Local application of statins in the treatment of experimental periodontal disease in rats |
author_facet |
SANTOS,Bianca Fernanda Espósito SOUZA,Eduardo Quintão Manhanini BRIGAGÃO,Maísa Ribeiro Pereira Lima LIMA,Daniela Coelho de FERNANDES,Leandro Araújo |
author_sort |
SANTOS,Bianca Fernanda Espósito |
title |
Local application of statins in the treatment of experimental periodontal disease in rats |
title_short |
Local application of statins in the treatment of experimental periodontal disease in rats |
title_full |
Local application of statins in the treatment of experimental periodontal disease in rats |
title_fullStr |
Local application of statins in the treatment of experimental periodontal disease in rats |
title_full_unstemmed |
Local application of statins in the treatment of experimental periodontal disease in rats |
title_sort |
local application of statins in the treatment of experimental periodontal disease in rats |
description |
Abstract Objective The objective of this study was to evaluate the local effects of statins as adjuvants for treatment by scaling and root planing (SRP) of periodontal disease induced in rats. Material and Methods Ninety rats were used in the present experiment. Periodontal disease was induced in all animals using a cotton thread placed in the left first mandibular molar. After 7 days of induction, the bandage was removed and the animals were divided into three groups: 1) NT group (n=30), no treatment; 2) SRP group (n=30): SRP and irrigation with control gel; 3) S group (n=30) - SRP and irrigation with Simvastatin. Ten animals from each group were euthanized at 7, 15 and 30 days after treatment. Gingival biopsy specimens were processed to analyze the expression of matrix metalloproteinase 8 (MMP-8). The mandibles were removed and submitted to radiographic and laboratory processing for histometric analysis. Results The S group showed a significantly lower expression of MMP-8 compared to NT and SRP groups in all experimental periods. In the radiographic and histometric analyses between the groups, S group showed a significantly lower bone loss (BL) compared to NT and SRP groups in all experimental periods. Conclusions Within the limits of this study, it can be concluded that locally applied statin was effective as an adjuvant treatment for SRP in rats with induced periodontal disease. |
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Faculdade De Odontologia De Bauru - USP |
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2017 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572017000200168 |
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