Direct genotoxicity and mutagenicity of endodontic substances and materials as evaluated by two prokaryotic test systems
Substances and materials used in endodontic therapy come into close contact with the periradicular tissues via apical foramen and foramina. Consequently, they should possess biocompatibility. There are currently few studies describing the genotoxic and mutagenic potentials of substances and materials used in endodontics. The purpose of this study was to evaluate the direct genotoxic and mutagenic properties of several substances and materials used in different phases of the endodontic treatment. For this intent, two prokaryotic test systems were used: the SOS chromotest and the Ames test. No metabolization with S9 was investigated, since only the direct effects of the substances and materials were surveyed. Most of the substances and materials tested presented mild to moderate cytotoxicity and genotoxicity as revealed by the SOS chromotest. Formocresol was the only tested substance to present severe genotoxicity to the tester bacterial strains. However, no substance or material tested showed direct mutagenicity as revealed by the Ames test.
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Faculdade De Odontologia De Bauru - USP
2005
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oai:scielo:S1678-775720050004000142006-01-20Direct genotoxicity and mutagenicity of endodontic substances and materials as evaluated by two prokaryotic test systemsGahyva,Sérgio Márcio MottaSiqueira Junior,José Freitas Root canal therapy Intracanal medication Root canal irrigants Root canal filling materials Genotoxycity tests Mutagenicity tests Substances and materials used in endodontic therapy come into close contact with the periradicular tissues via apical foramen and foramina. Consequently, they should possess biocompatibility. There are currently few studies describing the genotoxic and mutagenic potentials of substances and materials used in endodontics. The purpose of this study was to evaluate the direct genotoxic and mutagenic properties of several substances and materials used in different phases of the endodontic treatment. For this intent, two prokaryotic test systems were used: the SOS chromotest and the Ames test. No metabolization with S9 was investigated, since only the direct effects of the substances and materials were surveyed. Most of the substances and materials tested presented mild to moderate cytotoxicity and genotoxicity as revealed by the SOS chromotest. Formocresol was the only tested substance to present severe genotoxicity to the tester bacterial strains. However, no substance or material tested showed direct mutagenicity as revealed by the Ames test.info:eu-repo/semantics/openAccessFaculdade De Odontologia De Bauru - USPJournal of Applied Oral Science v.13 n.4 20052005-12-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1678-77572005000400014en10.1590/S1678-77572005000400014 |
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Gahyva,Sérgio Márcio Motta Siqueira Junior,José Freitas |
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Gahyva,Sérgio Márcio Motta Siqueira Junior,José Freitas Direct genotoxicity and mutagenicity of endodontic substances and materials as evaluated by two prokaryotic test systems |
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Gahyva,Sérgio Márcio Motta Siqueira Junior,José Freitas |
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Gahyva,Sérgio Márcio Motta |
title |
Direct genotoxicity and mutagenicity of endodontic substances and materials as evaluated by two prokaryotic test systems |
title_short |
Direct genotoxicity and mutagenicity of endodontic substances and materials as evaluated by two prokaryotic test systems |
title_full |
Direct genotoxicity and mutagenicity of endodontic substances and materials as evaluated by two prokaryotic test systems |
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Direct genotoxicity and mutagenicity of endodontic substances and materials as evaluated by two prokaryotic test systems |
title_full_unstemmed |
Direct genotoxicity and mutagenicity of endodontic substances and materials as evaluated by two prokaryotic test systems |
title_sort |
direct genotoxicity and mutagenicity of endodontic substances and materials as evaluated by two prokaryotic test systems |
description |
Substances and materials used in endodontic therapy come into close contact with the periradicular tissues via apical foramen and foramina. Consequently, they should possess biocompatibility. There are currently few studies describing the genotoxic and mutagenic potentials of substances and materials used in endodontics. The purpose of this study was to evaluate the direct genotoxic and mutagenic properties of several substances and materials used in different phases of the endodontic treatment. For this intent, two prokaryotic test systems were used: the SOS chromotest and the Ames test. No metabolization with S9 was investigated, since only the direct effects of the substances and materials were surveyed. Most of the substances and materials tested presented mild to moderate cytotoxicity and genotoxicity as revealed by the SOS chromotest. Formocresol was the only tested substance to present severe genotoxicity to the tester bacterial strains. However, no substance or material tested showed direct mutagenicity as revealed by the Ames test. |
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Faculdade De Odontologia De Bauru - USP |
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2005 |
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