Predictive and prognostic impact of preoperative complete blood count based systemic inflammatory markers in testicular cancer
ABSTRACT Purpose To determine the utility of preoperative complete blood count (CBC) based systemic inflammatory markers in the prediction of testicular cancer and its prognosis. Material and Methods Between 2008-2017 the data of all testicular tumor patients undergoing radical orchiectomy were retrospectively analyzed. Patient baseseline characteristics (age, tumor stage, tumor markers, etc.) and results of routine preoperative blood tests including mean platelet volume (MPV), red cell distribution width (RDW), lymphocyte ratio (LR) and neutrophil ratio (NR) were retrieved. In addition, neutrophil to lymphocyte ratio (NLR) was calculated. Results Mean age of the tumor and control group was 36.0±15 and 30.50±11 years, respectively. Mean RDW, NR and NLR were significantly higher in the tumor group with p values<0.001; whereas LR and MPV were significantly higher in the control group (p<0.001). Receiver Operating Characteristic (ROC) analyses of LR, NR, RDW, MPV, and NLR are shown in Table-3. The cut off values for RDW and NR were found as 13,7 (Area under the curve (AUC): 0.687, sensitivity = 42.2%, specificity = 84.8%) and 55.3 (AUC:0.693, sensitivity 72.2%, specificity 62%), respectively. Area under the curve for NLR in tumor group was 0.711, with a threshold value of 1.78 and sensitivity=81.8% and specificity=55.4% (AUC:0.711/sig<0.001) that together with RDW exhibited the best differential diagnosis potential which could be used as an adjuvant tool in the prediction of testicular tumor and its prognosis. Conclusion Several systemic inflammatory markers, which are obtained by routinely performed cost-effective blood tests, could demonstrate incremental predictive and prognostic information adjuvant to preoperativly achieved testiscular tumor markers.
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Sociedade Brasileira de Urologia
2020
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oai:scielo:S1677-553820200002002162020-02-17Predictive and prognostic impact of preoperative complete blood count based systemic inflammatory markers in testicular cancerArda,ErsanArikan,GurkanAkdere,HakanAkgul,MuratYuksel,Ilkan Testicular Neoplasms Neutrophils Lymphocytes ABSTRACT Purpose To determine the utility of preoperative complete blood count (CBC) based systemic inflammatory markers in the prediction of testicular cancer and its prognosis. Material and Methods Between 2008-2017 the data of all testicular tumor patients undergoing radical orchiectomy were retrospectively analyzed. Patient baseseline characteristics (age, tumor stage, tumor markers, etc.) and results of routine preoperative blood tests including mean platelet volume (MPV), red cell distribution width (RDW), lymphocyte ratio (LR) and neutrophil ratio (NR) were retrieved. In addition, neutrophil to lymphocyte ratio (NLR) was calculated. Results Mean age of the tumor and control group was 36.0±15 and 30.50±11 years, respectively. Mean RDW, NR and NLR were significantly higher in the tumor group with p values<0.001; whereas LR and MPV were significantly higher in the control group (p<0.001). Receiver Operating Characteristic (ROC) analyses of LR, NR, RDW, MPV, and NLR are shown in Table-3. The cut off values for RDW and NR were found as 13,7 (Area under the curve (AUC): 0.687, sensitivity = 42.2%, specificity = 84.8%) and 55.3 (AUC:0.693, sensitivity 72.2%, specificity 62%), respectively. Area under the curve for NLR in tumor group was 0.711, with a threshold value of 1.78 and sensitivity=81.8% and specificity=55.4% (AUC:0.711/sig<0.001) that together with RDW exhibited the best differential diagnosis potential which could be used as an adjuvant tool in the prediction of testicular tumor and its prognosis. Conclusion Several systemic inflammatory markers, which are obtained by routinely performed cost-effective blood tests, could demonstrate incremental predictive and prognostic information adjuvant to preoperativly achieved testiscular tumor markers.info:eu-repo/semantics/openAccessSociedade Brasileira de UrologiaInternational braz j urol v.46 n.2 20202020-03-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382020000200216en10.1590/s1677-5538.ibju.2018.0820 |
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Arda,Ersan Arikan,Gurkan Akdere,Hakan Akgul,Murat Yuksel,Ilkan |
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Arda,Ersan Arikan,Gurkan Akdere,Hakan Akgul,Murat Yuksel,Ilkan Predictive and prognostic impact of preoperative complete blood count based systemic inflammatory markers in testicular cancer |
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Arda,Ersan Arikan,Gurkan Akdere,Hakan Akgul,Murat Yuksel,Ilkan |
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Arda,Ersan |
title |
Predictive and prognostic impact of preoperative complete blood count based systemic inflammatory markers in testicular cancer |
title_short |
Predictive and prognostic impact of preoperative complete blood count based systemic inflammatory markers in testicular cancer |
title_full |
Predictive and prognostic impact of preoperative complete blood count based systemic inflammatory markers in testicular cancer |
title_fullStr |
Predictive and prognostic impact of preoperative complete blood count based systemic inflammatory markers in testicular cancer |
title_full_unstemmed |
Predictive and prognostic impact of preoperative complete blood count based systemic inflammatory markers in testicular cancer |
title_sort |
predictive and prognostic impact of preoperative complete blood count based systemic inflammatory markers in testicular cancer |
description |
ABSTRACT Purpose To determine the utility of preoperative complete blood count (CBC) based systemic inflammatory markers in the prediction of testicular cancer and its prognosis. Material and Methods Between 2008-2017 the data of all testicular tumor patients undergoing radical orchiectomy were retrospectively analyzed. Patient baseseline characteristics (age, tumor stage, tumor markers, etc.) and results of routine preoperative blood tests including mean platelet volume (MPV), red cell distribution width (RDW), lymphocyte ratio (LR) and neutrophil ratio (NR) were retrieved. In addition, neutrophil to lymphocyte ratio (NLR) was calculated. Results Mean age of the tumor and control group was 36.0±15 and 30.50±11 years, respectively. Mean RDW, NR and NLR were significantly higher in the tumor group with p values<0.001; whereas LR and MPV were significantly higher in the control group (p<0.001). Receiver Operating Characteristic (ROC) analyses of LR, NR, RDW, MPV, and NLR are shown in Table-3. The cut off values for RDW and NR were found as 13,7 (Area under the curve (AUC): 0.687, sensitivity = 42.2%, specificity = 84.8%) and 55.3 (AUC:0.693, sensitivity 72.2%, specificity 62%), respectively. Area under the curve for NLR in tumor group was 0.711, with a threshold value of 1.78 and sensitivity=81.8% and specificity=55.4% (AUC:0.711/sig<0.001) that together with RDW exhibited the best differential diagnosis potential which could be used as an adjuvant tool in the prediction of testicular tumor and its prognosis. Conclusion Several systemic inflammatory markers, which are obtained by routinely performed cost-effective blood tests, could demonstrate incremental predictive and prognostic information adjuvant to preoperativly achieved testiscular tumor markers. |
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Sociedade Brasileira de Urologia |
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2020 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382020000200216 |
work_keys_str_mv |
AT ardaersan predictiveandprognosticimpactofpreoperativecompletebloodcountbasedsystemicinflammatorymarkersintesticularcancer AT arikangurkan predictiveandprognosticimpactofpreoperativecompletebloodcountbasedsystemicinflammatorymarkersintesticularcancer AT akderehakan predictiveandprognosticimpactofpreoperativecompletebloodcountbasedsystemicinflammatorymarkersintesticularcancer AT akgulmurat predictiveandprognosticimpactofpreoperativecompletebloodcountbasedsystemicinflammatorymarkersintesticularcancer AT yukselilkan predictiveandprognosticimpactofpreoperativecompletebloodcountbasedsystemicinflammatorymarkersintesticularcancer |
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1756428301511950336 |