Evaluation of apoptosis indexes in currently used oral alpha-blockers in prostate: a pilot study

ABSTRACT Objectives: Apoptosis effect of oral alpha-blockers is known in the prostate. Apoptosis index of silodosin has not been proved, yet. Aims are to present apoptosis index of silodosin in prostate and to compare this with other currently used alpha-blocker's apoptosis indexes together with their clinical effects. Materials and Methods: Benign prostatic hyperplasia (BPH) patients were enrolled among those admitted to urology outpatient clinic between June 2014 and June 2015. Study groups were created according to randomly prescribed oral alpha-blocker drugs as silodosin 8mg (Group 1; n=24), tamsulosin 0.4mg (Group 2; n=30), alfuzosin 10mg (Group 3; n=25), doxazosin 8mg (Group 4; n=22), terazosin 5mg (Group 5; n=15). Pa- tients who refused to use any alpha-blocker drug were included into Group 6 as control group (n=16). We investigated apoptosis indexes of the drugs in prostatic tissues that were taken from patient's surgery (transurethral resection of prostate) and/or prostate biopsies. Immunochemical dyeing, light microscope, and Image Processing and Analy- sis in Java were used for evaluations. Statistical significant p was p<0.05. Results: There were 132 patients with mean follow-up of 4.2±2.1 months. Pathologist researched randomly selected 10 areas in each microscope set. Group 1 showed statisti- cal significant difference apoptosis index in immunochemical TUNEL dyeing and im- age software (p<0.001). Moreover, we determined superior significant development in parameters as uroflowmetry, quality of life scores, and international prostate symptom score in Group 1. Conclusions: Silodosin has higher apoptosis effect than other alpha-blockers in prostate. Thus, clinic improvement with silodosin was proved by histologic studies. Besides, static factor of BPH may be overcome with creating apoptosis.

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Main Authors: Demir,Mehmet, Akin,Yigit, Terim,Kubra Asena Kapakin, Gulum,Mehmet, Buyukfirat,Evren, Ciftci,Halil, Yeni,Ercan
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Urologia 2018
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382018000300600
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spelling oai:scielo:S1677-553820180003006002018-06-22Evaluation of apoptosis indexes in currently used oral alpha-blockers in prostate: a pilot studyDemir,MehmetAkin,YigitTerim,Kubra Asena KapakinGulum,MehmetBuyukfirat,EvrenCiftci,HalilYeni,Ercan Prostate Prostatic Hyperplasia 5-alpha Reductase Inhibitors ABSTRACT Objectives: Apoptosis effect of oral alpha-blockers is known in the prostate. Apoptosis index of silodosin has not been proved, yet. Aims are to present apoptosis index of silodosin in prostate and to compare this with other currently used alpha-blocker's apoptosis indexes together with their clinical effects. Materials and Methods: Benign prostatic hyperplasia (BPH) patients were enrolled among those admitted to urology outpatient clinic between June 2014 and June 2015. Study groups were created according to randomly prescribed oral alpha-blocker drugs as silodosin 8mg (Group 1; n=24), tamsulosin 0.4mg (Group 2; n=30), alfuzosin 10mg (Group 3; n=25), doxazosin 8mg (Group 4; n=22), terazosin 5mg (Group 5; n=15). Pa- tients who refused to use any alpha-blocker drug were included into Group 6 as control group (n=16). We investigated apoptosis indexes of the drugs in prostatic tissues that were taken from patient's surgery (transurethral resection of prostate) and/or prostate biopsies. Immunochemical dyeing, light microscope, and Image Processing and Analy- sis in Java were used for evaluations. Statistical significant p was p<0.05. Results: There were 132 patients with mean follow-up of 4.2±2.1 months. Pathologist researched randomly selected 10 areas in each microscope set. Group 1 showed statisti- cal significant difference apoptosis index in immunochemical TUNEL dyeing and im- age software (p<0.001). Moreover, we determined superior significant development in parameters as uroflowmetry, quality of life scores, and international prostate symptom score in Group 1. Conclusions: Silodosin has higher apoptosis effect than other alpha-blockers in prostate. Thus, clinic improvement with silodosin was proved by histologic studies. Besides, static factor of BPH may be overcome with creating apoptosis.info:eu-repo/semantics/openAccessSociedade Brasileira de UrologiaInternational braz j urol v.44 n.3 20182018-06-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382018000300600en10.1590/s1677-5538.ibju.2017.0668
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libraryname SciELO
language English
format Digital
author Demir,Mehmet
Akin,Yigit
Terim,Kubra Asena Kapakin
Gulum,Mehmet
Buyukfirat,Evren
Ciftci,Halil
Yeni,Ercan
spellingShingle Demir,Mehmet
Akin,Yigit
Terim,Kubra Asena Kapakin
Gulum,Mehmet
Buyukfirat,Evren
Ciftci,Halil
Yeni,Ercan
Evaluation of apoptosis indexes in currently used oral alpha-blockers in prostate: a pilot study
author_facet Demir,Mehmet
Akin,Yigit
Terim,Kubra Asena Kapakin
Gulum,Mehmet
Buyukfirat,Evren
Ciftci,Halil
Yeni,Ercan
author_sort Demir,Mehmet
title Evaluation of apoptosis indexes in currently used oral alpha-blockers in prostate: a pilot study
title_short Evaluation of apoptosis indexes in currently used oral alpha-blockers in prostate: a pilot study
title_full Evaluation of apoptosis indexes in currently used oral alpha-blockers in prostate: a pilot study
title_fullStr Evaluation of apoptosis indexes in currently used oral alpha-blockers in prostate: a pilot study
title_full_unstemmed Evaluation of apoptosis indexes in currently used oral alpha-blockers in prostate: a pilot study
title_sort evaluation of apoptosis indexes in currently used oral alpha-blockers in prostate: a pilot study
description ABSTRACT Objectives: Apoptosis effect of oral alpha-blockers is known in the prostate. Apoptosis index of silodosin has not been proved, yet. Aims are to present apoptosis index of silodosin in prostate and to compare this with other currently used alpha-blocker's apoptosis indexes together with their clinical effects. Materials and Methods: Benign prostatic hyperplasia (BPH) patients were enrolled among those admitted to urology outpatient clinic between June 2014 and June 2015. Study groups were created according to randomly prescribed oral alpha-blocker drugs as silodosin 8mg (Group 1; n=24), tamsulosin 0.4mg (Group 2; n=30), alfuzosin 10mg (Group 3; n=25), doxazosin 8mg (Group 4; n=22), terazosin 5mg (Group 5; n=15). Pa- tients who refused to use any alpha-blocker drug were included into Group 6 as control group (n=16). We investigated apoptosis indexes of the drugs in prostatic tissues that were taken from patient's surgery (transurethral resection of prostate) and/or prostate biopsies. Immunochemical dyeing, light microscope, and Image Processing and Analy- sis in Java were used for evaluations. Statistical significant p was p<0.05. Results: There were 132 patients with mean follow-up of 4.2±2.1 months. Pathologist researched randomly selected 10 areas in each microscope set. Group 1 showed statisti- cal significant difference apoptosis index in immunochemical TUNEL dyeing and im- age software (p<0.001). Moreover, we determined superior significant development in parameters as uroflowmetry, quality of life scores, and international prostate symptom score in Group 1. Conclusions: Silodosin has higher apoptosis effect than other alpha-blockers in prostate. Thus, clinic improvement with silodosin was proved by histologic studies. Besides, static factor of BPH may be overcome with creating apoptosis.
publisher Sociedade Brasileira de Urologia
publishDate 2018
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382018000300600
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