Serum Levels of Trace Elements in Patients with Testicular Cancers
Introduction: Trace elements are primary components of biological structures; however, they can be toxic when their concentrations are higher than those needed for biological functions. Materials and Methods: In the present study serum levels of trace elements were measured in 30 patients (mean age was 26.9±11.2 years) newly diagnosed with germ cell testicular cancer and 32 healthy volunteers (mean age: 27.4±10.8) by using furnace atomic absorption spectrophotometer. Serum samples were stored at-20°C until assays. Results: In patients with germ cell testicular cancer, the diagnosis was seminoma in 15, mix germ cell tumor in 7, embryonal carcinoma in 4, yolk sac tumor in 2 and teratoma in 2 patients. There was stage I testicular tumor in 19 patients (63.3%) while stage II in 6 patients (20.0%), stage IIIA in 4 patients (13.3%) and stage IIIC in one patient (3.4%). It was found that serum Co, Cu, Mg and Pb levels were increased (p<0.05), whereas Fe, Mn, and Zn levels were decreased in patients with testicular cancer (p<0.05). Conclusions: These alterations may be important in the pathogenesis of testicular cancers; however, further prospective studies are needed to identify the relationship between testicular cancer and trace elements.
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Sociedade Brasileira de Urologia
2015
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oai:scielo:S1677-553820150006011012016-01-13Serum Levels of Trace Elements in Patients with Testicular CancersKaba,MehmetPirinççi,NecipYüksel,Mehmet BilgehanGeçit,İlhanGüneş,MustafaDemir,MuratAkkoyun,HurremTuranDemir,Halit Testicular Neoplasms Trace Elements Tumor Markers Biological Introduction: Trace elements are primary components of biological structures; however, they can be toxic when their concentrations are higher than those needed for biological functions. Materials and Methods: In the present study serum levels of trace elements were measured in 30 patients (mean age was 26.9±11.2 years) newly diagnosed with germ cell testicular cancer and 32 healthy volunteers (mean age: 27.4±10.8) by using furnace atomic absorption spectrophotometer. Serum samples were stored at-20°C until assays. Results: In patients with germ cell testicular cancer, the diagnosis was seminoma in 15, mix germ cell tumor in 7, embryonal carcinoma in 4, yolk sac tumor in 2 and teratoma in 2 patients. There was stage I testicular tumor in 19 patients (63.3%) while stage II in 6 patients (20.0%), stage IIIA in 4 patients (13.3%) and stage IIIC in one patient (3.4%). It was found that serum Co, Cu, Mg and Pb levels were increased (p<0.05), whereas Fe, Mn, and Zn levels were decreased in patients with testicular cancer (p<0.05). Conclusions: These alterations may be important in the pathogenesis of testicular cancers; however, further prospective studies are needed to identify the relationship between testicular cancer and trace elements.info:eu-repo/semantics/openAccessSociedade Brasileira de UrologiaInternational braz j urol v.41 n.6 20152015-12-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382015000601101en10.1590/S1677-5538.IBJU.2014.0460 |
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Kaba,Mehmet Pirinççi,Necip Yüksel,Mehmet Bilgehan Geçit,İlhan Güneş,Mustafa Demir,Murat Akkoyun,HurremTuran Demir,Halit |
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Kaba,Mehmet Pirinççi,Necip Yüksel,Mehmet Bilgehan Geçit,İlhan Güneş,Mustafa Demir,Murat Akkoyun,HurremTuran Demir,Halit Serum Levels of Trace Elements in Patients with Testicular Cancers |
author_facet |
Kaba,Mehmet Pirinççi,Necip Yüksel,Mehmet Bilgehan Geçit,İlhan Güneş,Mustafa Demir,Murat Akkoyun,HurremTuran Demir,Halit |
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Kaba,Mehmet |
title |
Serum Levels of Trace Elements in Patients with Testicular Cancers |
title_short |
Serum Levels of Trace Elements in Patients with Testicular Cancers |
title_full |
Serum Levels of Trace Elements in Patients with Testicular Cancers |
title_fullStr |
Serum Levels of Trace Elements in Patients with Testicular Cancers |
title_full_unstemmed |
Serum Levels of Trace Elements in Patients with Testicular Cancers |
title_sort |
serum levels of trace elements in patients with testicular cancers |
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Introduction: Trace elements are primary components of biological structures; however, they can be toxic when their concentrations are higher than those needed for biological functions. Materials and Methods: In the present study serum levels of trace elements were measured in 30 patients (mean age was 26.9±11.2 years) newly diagnosed with germ cell testicular cancer and 32 healthy volunteers (mean age: 27.4±10.8) by using furnace atomic absorption spectrophotometer. Serum samples were stored at-20°C until assays. Results: In patients with germ cell testicular cancer, the diagnosis was seminoma in 15, mix germ cell tumor in 7, embryonal carcinoma in 4, yolk sac tumor in 2 and teratoma in 2 patients. There was stage I testicular tumor in 19 patients (63.3%) while stage II in 6 patients (20.0%), stage IIIA in 4 patients (13.3%) and stage IIIC in one patient (3.4%). It was found that serum Co, Cu, Mg and Pb levels were increased (p<0.05), whereas Fe, Mn, and Zn levels were decreased in patients with testicular cancer (p<0.05). Conclusions: These alterations may be important in the pathogenesis of testicular cancers; however, further prospective studies are needed to identify the relationship between testicular cancer and trace elements. |
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Sociedade Brasileira de Urologia |
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2015 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382015000601101 |
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AT kabamehmet serumlevelsoftraceelementsinpatientswithtesticularcancers AT pirinccinecip serumlevelsoftraceelementsinpatientswithtesticularcancers AT yukselmehmetbilgehan serumlevelsoftraceelementsinpatientswithtesticularcancers AT gecitilhan serumlevelsoftraceelementsinpatientswithtesticularcancers AT gunesmustafa serumlevelsoftraceelementsinpatientswithtesticularcancers AT demirmurat serumlevelsoftraceelementsinpatientswithtesticularcancers AT akkoyunhurremturan serumlevelsoftraceelementsinpatientswithtesticularcancers AT demirhalit serumlevelsoftraceelementsinpatientswithtesticularcancers |
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