Inclusion-body myositis: a difficult diagnosis?

Inclusion-body myositis: a difficult diagnosis?

Sporadic inclusion-body myositis (IBM) is the most common myopathy in individuals over 55 years of age. However, in many cases, the diagnosis is neglected. Its main findings include progressive muscle weakness, normal or low levels of serum creatine kinase, and the absence of a response to immunosuppression. Muscle biopsy shows inflammatory reaction in association with degenerative changes of the muscle fibers. We report a typical case of IBM, in which diagnosis was possible only after three muscle biopsies. The challenges to confirm histological diagnosis and the caution to avoid repeating tests are discussed.

Saved in:
Bibliographic Details
Main Authors: Correia,Carolina da Cunha, Magalhães,Maria Clara de Oliveira, Barbosa,Pedro Lucas de Mendonça, Campos,Eliene Dutra, Zanoteli,Edmar
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Patologia Clínica 2014
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442014000500364
Tags: Add Tag
No Tags, Be the first to tag this record!
id oai:scielo:S1676-24442014000500364
record_format ojs
spelling oai:scielo:S1676-244420140005003642014-12-09Inclusion-body myositis: a difficult diagnosis?Correia,Carolina da CunhaMagalhães,Maria Clara de OliveiraBarbosa,Pedro Lucas de MendonçaCampos,Eliene DutraZanoteli,Edmar skeletal muscle myositis muscular diseases biopsy muscle weakness. Sporadic inclusion-body myositis (IBM) is the most common myopathy in individuals over 55 years of age. However, in many cases, the diagnosis is neglected. Its main findings include progressive muscle weakness, normal or low levels of serum creatine kinase, and the absence of a response to immunosuppression. Muscle biopsy shows inflammatory reaction in association with degenerative changes of the muscle fibers. We report a typical case of IBM, in which diagnosis was possible only after three muscle biopsies. The challenges to confirm histological diagnosis and the caution to avoid repeating tests are discussed.info:eu-repo/semantics/openAccessSociedade Brasileira de Patologia Clínica Jornal Brasileiro de Patologia e Medicina Laboratorial v.50 n.5 20142014-10-01info:eu-repo/semantics/reporttext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442014000500364en10.5935/1676-2444.20140041
institution SCIELO
collection OJS
country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author Correia,Carolina da Cunha
Magalhães,Maria Clara de Oliveira
Barbosa,Pedro Lucas de Mendonça
Campos,Eliene Dutra
Zanoteli,Edmar
spellingShingle Correia,Carolina da Cunha
Magalhães,Maria Clara de Oliveira
Barbosa,Pedro Lucas de Mendonça
Campos,Eliene Dutra
Zanoteli,Edmar
Inclusion-body myositis: a difficult diagnosis?
author_facet Correia,Carolina da Cunha
Magalhães,Maria Clara de Oliveira
Barbosa,Pedro Lucas de Mendonça
Campos,Eliene Dutra
Zanoteli,Edmar
author_sort Correia,Carolina da Cunha
title Inclusion-body myositis: a difficult diagnosis?
title_short Inclusion-body myositis: a difficult diagnosis?
title_full Inclusion-body myositis: a difficult diagnosis?
title_fullStr Inclusion-body myositis: a difficult diagnosis?
title_full_unstemmed Inclusion-body myositis: a difficult diagnosis?
title_sort inclusion-body myositis: a difficult diagnosis?
description Sporadic inclusion-body myositis (IBM) is the most common myopathy in individuals over 55 years of age. However, in many cases, the diagnosis is neglected. Its main findings include progressive muscle weakness, normal or low levels of serum creatine kinase, and the absence of a response to immunosuppression. Muscle biopsy shows inflammatory reaction in association with degenerative changes of the muscle fibers. We report a typical case of IBM, in which diagnosis was possible only after three muscle biopsies. The challenges to confirm histological diagnosis and the caution to avoid repeating tests are discussed.
publisher Sociedade Brasileira de Patologia Clínica
publishDate 2014
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442014000500364
work_keys_str_mv AT correiacarolinadacunha inclusionbodymyositisadifficultdiagnosis
AT magalhaesmariaclaradeoliveira inclusionbodymyositisadifficultdiagnosis
AT barbosapedrolucasdemendonca inclusionbodymyositisadifficultdiagnosis
AT camposelienedutra inclusionbodymyositisadifficultdiagnosis
AT zanoteliedmar inclusionbodymyositisadifficultdiagnosis
_version_ 1756427506520424448

Similar Items