Inclusion-body myositis: a difficult diagnosis?
Sporadic inclusion-body myositis (IBM) is the most common myopathy in individuals over 55 years of age. However, in many cases, the diagnosis is neglected. Its main findings include progressive muscle weakness, normal or low levels of serum creatine kinase, and the absence of a response to immunosuppression. Muscle biopsy shows inflammatory reaction in association with degenerative changes of the muscle fibers. We report a typical case of IBM, in which diagnosis was possible only after three muscle biopsies. The challenges to confirm histological diagnosis and the caution to avoid repeating tests are discussed.
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Sociedade Brasileira de Patologia Clínica
2014
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oai:scielo:S1676-244420140005003642014-12-09Inclusion-body myositis: a difficult diagnosis?Correia,Carolina da CunhaMagalhães,Maria Clara de OliveiraBarbosa,Pedro Lucas de MendonçaCampos,Eliene DutraZanoteli,Edmar skeletal muscle myositis muscular diseases biopsy muscle weakness. Sporadic inclusion-body myositis (IBM) is the most common myopathy in individuals over 55 years of age. However, in many cases, the diagnosis is neglected. Its main findings include progressive muscle weakness, normal or low levels of serum creatine kinase, and the absence of a response to immunosuppression. Muscle biopsy shows inflammatory reaction in association with degenerative changes of the muscle fibers. We report a typical case of IBM, in which diagnosis was possible only after three muscle biopsies. The challenges to confirm histological diagnosis and the caution to avoid repeating tests are discussed.info:eu-repo/semantics/openAccessSociedade Brasileira de Patologia Clínica Jornal Brasileiro de Patologia e Medicina Laboratorial v.50 n.5 20142014-10-01info:eu-repo/semantics/reporttext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442014000500364en10.5935/1676-2444.20140041 |
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Correia,Carolina da Cunha Magalhães,Maria Clara de Oliveira Barbosa,Pedro Lucas de Mendonça Campos,Eliene Dutra Zanoteli,Edmar |
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Correia,Carolina da Cunha Magalhães,Maria Clara de Oliveira Barbosa,Pedro Lucas de Mendonça Campos,Eliene Dutra Zanoteli,Edmar Inclusion-body myositis: a difficult diagnosis? |
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Correia,Carolina da Cunha Magalhães,Maria Clara de Oliveira Barbosa,Pedro Lucas de Mendonça Campos,Eliene Dutra Zanoteli,Edmar |
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Correia,Carolina da Cunha |
title |
Inclusion-body myositis: a difficult diagnosis? |
title_short |
Inclusion-body myositis: a difficult diagnosis? |
title_full |
Inclusion-body myositis: a difficult diagnosis? |
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Inclusion-body myositis: a difficult diagnosis? |
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Inclusion-body myositis: a difficult diagnosis? |
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inclusion-body myositis: a difficult diagnosis? |
description |
Sporadic inclusion-body myositis (IBM) is the most common myopathy in individuals over 55 years of age. However, in many cases, the diagnosis is neglected. Its main findings include progressive muscle weakness, normal or low levels of serum creatine kinase, and the absence of a response to immunosuppression. Muscle biopsy shows inflammatory reaction in association with degenerative changes of the muscle fibers. We report a typical case of IBM, in which diagnosis was possible only after three muscle biopsies. The challenges to confirm histological diagnosis and the caution to avoid repeating tests are discussed. |
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Sociedade Brasileira de Patologia Clínica |
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2014 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442014000500364 |
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1756427506520424448 |