Breast cancer with choriocarcinomatous features

This report describes the case of a 45 year-old patient with breast carcinoma characterized by choriocarcinomatous features, presence of bizarre anaplastic cells with areas of necrosis and multinucleated giant cells. The immuno-histochemical analysis showed positivity for chromogranin and β-HCG. The tumor size was 5.7 cm at the largest axis and it was refractory to initial neo-adjuvant treatment. Mastectomy was performed and after microscopic and immuno-histochemical examination it was diagnosed as carcinoma with choriocarcinomatous features. These lesions are rare and liable to synthesize hormonal substances not specific to breast tissue. Its diagnosis is highly significant to the therapeutic and prognostic approach insofar as these lesions are potentially aggressive.

Bibliographic Details

Main Authors:	Rossetti,Claudia, Sacchi,Renata Silvia, Junqueira,Virginia Berlanga Campos, Fonseca,Fernando Luiz Affonso
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Patologia Clínica 2009
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1676-24442009000600008
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