Chronic active EBV infection: the experience of the Samsung Medical Center in South Korea

Chronic active EBV infection: the experience of the Samsung Medical Center in South Korea

Abstract Background: Chronic active EBV infection (CAEBV) of T-cell or NK-cell type is an EBV+ polyclonal, oligoclonal or often monoclonal lymphoproliferative disorder (LPD) recognized as representing the spectrum of EBV-associated T-cell and NK-cell LPD with different clinical presentations; one systemic and two cutaneous disorders including hydroa vacciniforme-like T-cell LPD and mosquito bite hypersensitivity. The systemic form of the disease is characterized by fever, persistent hepatitis, hepatosplenomegaly and lymphadenopathy, which shows varying degrees of clinical severity depending on the immune response of the host and the EBV viral load. Case reports: We described the clinicopathological findings of two children with CAEBV with a brief review of the literature. Conclusions: Recognition of the disease is important for adequate management of the patient. EBV analysis should be included in the principal diagnostic tests for febrile children.

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Main Authors: Lee,Tae-Hee, Ko,Young-Hyeh
Format: Digital revista
Language:English
Published: Instituto Nacional de Salud, Hospital Infantil de México Federico Gómez 2016
Online Access:http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1665-11462016000100010
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spelling oai:scielo:S1665-114620160001000102017-03-16Chronic active EBV infection: the experience of the Samsung Medical Center in South KoreaLee,Tae-HeeKo,Young-Hyeh Epstein-Barr virus Children Chronic active infection NK lymphocytosis Mosquito-bite hypersensitivity Abstract Background: Chronic active EBV infection (CAEBV) of T-cell or NK-cell type is an EBV+ polyclonal, oligoclonal or often monoclonal lymphoproliferative disorder (LPD) recognized as representing the spectrum of EBV-associated T-cell and NK-cell LPD with different clinical presentations; one systemic and two cutaneous disorders including hydroa vacciniforme-like T-cell LPD and mosquito bite hypersensitivity. The systemic form of the disease is characterized by fever, persistent hepatitis, hepatosplenomegaly and lymphadenopathy, which shows varying degrees of clinical severity depending on the immune response of the host and the EBV viral load. Case reports: We described the clinicopathological findings of two children with CAEBV with a brief review of the literature. Conclusions: Recognition of the disease is important for adequate management of the patient. EBV analysis should be included in the principal diagnostic tests for febrile children.info:eu-repo/semantics/openAccessInstituto Nacional de Salud, Hospital Infantil de México Federico GómezBoletín médico del Hospital Infantil de México v.73 n.1 20162016-02-01info:eu-repo/semantics/reporttext/htmlhttp://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1665-11462016000100010en10.1016/j.bmhimx.2015.12.003
institution SCIELO
collection OJS
country México
countrycode MX
component Revista
access En linea
databasecode rev-scielo-mx
tag revista
region America del Norte
libraryname SciELO
language English
format Digital
author Lee,Tae-Hee
Ko,Young-Hyeh
spellingShingle Lee,Tae-Hee
Ko,Young-Hyeh
Chronic active EBV infection: the experience of the Samsung Medical Center in South Korea
author_facet Lee,Tae-Hee
Ko,Young-Hyeh
author_sort Lee,Tae-Hee
title Chronic active EBV infection: the experience of the Samsung Medical Center in South Korea
title_short Chronic active EBV infection: the experience of the Samsung Medical Center in South Korea
title_full Chronic active EBV infection: the experience of the Samsung Medical Center in South Korea
title_fullStr Chronic active EBV infection: the experience of the Samsung Medical Center in South Korea
title_full_unstemmed Chronic active EBV infection: the experience of the Samsung Medical Center in South Korea
title_sort chronic active ebv infection: the experience of the samsung medical center in south korea
description Abstract Background: Chronic active EBV infection (CAEBV) of T-cell or NK-cell type is an EBV+ polyclonal, oligoclonal or often monoclonal lymphoproliferative disorder (LPD) recognized as representing the spectrum of EBV-associated T-cell and NK-cell LPD with different clinical presentations; one systemic and two cutaneous disorders including hydroa vacciniforme-like T-cell LPD and mosquito bite hypersensitivity. The systemic form of the disease is characterized by fever, persistent hepatitis, hepatosplenomegaly and lymphadenopathy, which shows varying degrees of clinical severity depending on the immune response of the host and the EBV viral load. Case reports: We described the clinicopathological findings of two children with CAEBV with a brief review of the literature. Conclusions: Recognition of the disease is important for adequate management of the patient. EBV analysis should be included in the principal diagnostic tests for febrile children.
publisher Instituto Nacional de Salud, Hospital Infantil de México Federico Gómez
publishDate 2016
url http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1665-11462016000100010
work_keys_str_mv AT leetaehee chronicactiveebvinfectiontheexperienceofthesamsungmedicalcenterinsouthkorea
AT koyounghyeh chronicactiveebvinfectiontheexperienceofthesamsungmedicalcenterinsouthkorea
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