Prostaglandin A1 inhibits the replication of bovine viral diarrhea virus

Prostaglandin A1 inhibits the replication of bovine viral diarrhea virus

ABSTRACT Bovine viral diarrhea virus can cause acute disease in livestock, leading to economic losses. We show that Prostaglandin A1 inhibits bovine viral diarrhea virus replication in Madin-Darby bovine kidney cells (94% inhibition using 5 µg/mL). Light and electron microscopy of infected cells shows that Prostaglandin A1 also prevents virus-induced vacuolization, but at higher concentrations (10 µg/mL).

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Main Authors: Caldas,Lúcio Ayres, Freitas,Tânia Rosária Pereira, Azevedo,Renata Campos, de Souza,Wanderley
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Microbiologia 2018
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822018000400785
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spelling oai:scielo:S1517-838220180004007852018-10-17Prostaglandin A1 inhibits the replication of bovine viral diarrhea virusCaldas,Lúcio AyresFreitas,Tânia Rosária PereiraAzevedo,Renata Camposde Souza,Wanderley Bovine viral diarrhea virus BVDV Prostaglandins Prostaglandin A1 Virus-induced vacuolization ABSTRACT Bovine viral diarrhea virus can cause acute disease in livestock, leading to economic losses. We show that Prostaglandin A1 inhibits bovine viral diarrhea virus replication in Madin-Darby bovine kidney cells (94% inhibition using 5 µg/mL). Light and electron microscopy of infected cells shows that Prostaglandin A1 also prevents virus-induced vacuolization, but at higher concentrations (10 µg/mL).info:eu-repo/semantics/openAccessSociedade Brasileira de MicrobiologiaBrazilian Journal of Microbiology v.49 n.4 20182018-12-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822018000400785en10.1016/j.bjm.2017.12.010
institution SCIELO
collection OJS
country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author Caldas,Lúcio Ayres
Freitas,Tânia Rosária Pereira
Azevedo,Renata Campos
de Souza,Wanderley
spellingShingle Caldas,Lúcio Ayres
Freitas,Tânia Rosária Pereira
Azevedo,Renata Campos
de Souza,Wanderley
Prostaglandin A1 inhibits the replication of bovine viral diarrhea virus
author_facet Caldas,Lúcio Ayres
Freitas,Tânia Rosária Pereira
Azevedo,Renata Campos
de Souza,Wanderley
author_sort Caldas,Lúcio Ayres
title Prostaglandin A1 inhibits the replication of bovine viral diarrhea virus
title_short Prostaglandin A1 inhibits the replication of bovine viral diarrhea virus
title_full Prostaglandin A1 inhibits the replication of bovine viral diarrhea virus
title_fullStr Prostaglandin A1 inhibits the replication of bovine viral diarrhea virus
title_full_unstemmed Prostaglandin A1 inhibits the replication of bovine viral diarrhea virus
title_sort prostaglandin a1 inhibits the replication of bovine viral diarrhea virus
description ABSTRACT Bovine viral diarrhea virus can cause acute disease in livestock, leading to economic losses. We show that Prostaglandin A1 inhibits bovine viral diarrhea virus replication in Madin-Darby bovine kidney cells (94% inhibition using 5 µg/mL). Light and electron microscopy of infected cells shows that Prostaglandin A1 also prevents virus-induced vacuolization, but at higher concentrations (10 µg/mL).
publisher Sociedade Brasileira de Microbiologia
publishDate 2018
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822018000400785
work_keys_str_mv AT caldaslucioayres prostaglandina1inhibitsthereplicationofbovineviraldiarrheavirus
AT freitastaniarosariapereira prostaglandina1inhibitsthereplicationofbovineviraldiarrheavirus
AT azevedorenatacampos prostaglandina1inhibitsthereplicationofbovineviraldiarrheavirus
AT desouzawanderley prostaglandina1inhibitsthereplicationofbovineviraldiarrheavirus
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