Mobile genetic elements related to carbapenem resistance in Acinetobacter baumannii
Abstract Acinetobacter baumannii is widely recognized as an important pathogen associated with nosocomial infections. The treatment of these infections is often difficult due to the acquisition of resistance genes. A. baumannii presents a high genetic plasticity which allows the accumulation of these resistance determinants leading to multidrug resistance. It is highlighted the importance of the horizontal transfer of resistance genes, through mobile genetic elements and its relationship with increased incidence of multidrug resistant A. baumannii in hospitals. Considering that resistance to carbapenems is very important from the clinical and epidemiological point of view, the aim of this article is to present an overview of the current knowledge about genetic elements related to carbapenem resistance in A. baumannii such as integrons, transposons, resistance islands and insertion sequences.
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Sociedade Brasileira de Microbiologia
2016
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oai:scielo:S1517-838220160004007852016-11-21Mobile genetic elements related to carbapenem resistance in Acinetobacter baumanniiPagano,MarianaMartins,Andreza FranciscoBarth,Afonso Luis Acinetobacter baumannii Antimicrobial resistance Mobile genetic elements Carbapenem resistance Abstract Acinetobacter baumannii is widely recognized as an important pathogen associated with nosocomial infections. The treatment of these infections is often difficult due to the acquisition of resistance genes. A. baumannii presents a high genetic plasticity which allows the accumulation of these resistance determinants leading to multidrug resistance. It is highlighted the importance of the horizontal transfer of resistance genes, through mobile genetic elements and its relationship with increased incidence of multidrug resistant A. baumannii in hospitals. Considering that resistance to carbapenems is very important from the clinical and epidemiological point of view, the aim of this article is to present an overview of the current knowledge about genetic elements related to carbapenem resistance in A. baumannii such as integrons, transposons, resistance islands and insertion sequences.info:eu-repo/semantics/openAccessSociedade Brasileira de MicrobiologiaBrazilian Journal of Microbiology v.47 n.4 20162016-12-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822016000400785en10.1016/j.bjm.2016.06.005 |
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Pagano,Mariana Martins,Andreza Francisco Barth,Afonso Luis |
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Pagano,Mariana Martins,Andreza Francisco Barth,Afonso Luis Mobile genetic elements related to carbapenem resistance in Acinetobacter baumannii |
| author_facet |
Pagano,Mariana Martins,Andreza Francisco Barth,Afonso Luis |
| author_sort |
Pagano,Mariana |
| title |
Mobile genetic elements related to carbapenem resistance in Acinetobacter baumannii |
| title_short |
Mobile genetic elements related to carbapenem resistance in Acinetobacter baumannii |
| title_full |
Mobile genetic elements related to carbapenem resistance in Acinetobacter baumannii |
| title_fullStr |
Mobile genetic elements related to carbapenem resistance in Acinetobacter baumannii |
| title_full_unstemmed |
Mobile genetic elements related to carbapenem resistance in Acinetobacter baumannii |
| title_sort |
mobile genetic elements related to carbapenem resistance in acinetobacter baumannii |
| description |
Abstract Acinetobacter baumannii is widely recognized as an important pathogen associated with nosocomial infections. The treatment of these infections is often difficult due to the acquisition of resistance genes. A. baumannii presents a high genetic plasticity which allows the accumulation of these resistance determinants leading to multidrug resistance. It is highlighted the importance of the horizontal transfer of resistance genes, through mobile genetic elements and its relationship with increased incidence of multidrug resistant A. baumannii in hospitals. Considering that resistance to carbapenems is very important from the clinical and epidemiological point of view, the aim of this article is to present an overview of the current knowledge about genetic elements related to carbapenem resistance in A. baumannii such as integrons, transposons, resistance islands and insertion sequences. |
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Sociedade Brasileira de Microbiologia |
| publishDate |
2016 |
| url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822016000400785 |
| work_keys_str_mv |
AT paganomariana mobilegeneticelementsrelatedtocarbapenemresistanceinacinetobacterbaumannii AT martinsandrezafrancisco mobilegeneticelementsrelatedtocarbapenemresistanceinacinetobacterbaumannii AT barthafonsoluis mobilegeneticelementsrelatedtocarbapenemresistanceinacinetobacterbaumannii |
| _version_ |
1756425106686476288 |