Evaluation of inorganic and organic bone components after application of an apatite-coated Al2O3 implants as scaffolds for bone repair

Evaluation of inorganic and organic bone components after application of an apatite-coated Al2O3 implants as scaffolds for bone repair

The aim of this work was to study the influence of uncoated and apatite-coated Al2O3 implants on bone regeneration after 30 days of surgery in New Zealand white rabbits. Twelve samples of Al2O3 implants were prepared and half of them (n = 6) were apatite-coated by the modified biomimetic method. Three experimental groups were tested as Group C - control, surgery procedure without cerami c implant, Group Ce - uncoated Al 2O3 implants (n = 6) and Group CeHA - apatite-coated Al2O3 implants (n = 6). The mineralization of the Al2O3 implants was analyzed in bone fragments using FT-Raman spectroscopy. Raman peaks at 959 cm-1 and 2940 cm-1 evaluated the inorganic and organic bone content, respectively. In vivo citotoxicity was analyzed using micronucleus test. Inorganic and organic content were higher in CeHA samples than in Ce and C (CeHA > Ce > C). FT-Raman spectroscopy showed that the higher the deposition of the organic matrix, more mineralization occurred. The micronucleus test showed that the uncoated and apatite-coated Al2O3 implants were non-cytotoxic and safe to in vivo applications.

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Main Authors: Maia Filho,Antonio Luiz Martins, Amaral,Fabrício Pires de Moura do, Martin,Airton Abrahão, Soares,Luís Eduardo Silva
Format: Digital revista
Language:English
Published: Instituto de Tecnologia do Paraná - Tecpar 2014
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132014000300004
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spelling oai:scielo:S1516-891320140003000042014-05-30Evaluation of inorganic and organic bone components after application of an apatite-coated Al2O3 implants as scaffolds for bone repairMaia Filho,Antonio Luiz MartinsAmaral,Fabrício Pires de Moura doMartin,Airton AbrahãoSoares,Luís Eduardo Silva Bone regeneration Alumina foams Apatite coating FT-Raman spectroscopy Micronucleus test The aim of this work was to study the influence of uncoated and apatite-coated Al2O3 implants on bone regeneration after 30 days of surgery in New Zealand white rabbits. Twelve samples of Al2O3 implants were prepared and half of them (n = 6) were apatite-coated by the modified biomimetic method. Three experimental groups were tested as Group C - control, surgery procedure without cerami c implant, Group Ce - uncoated Al 2O3 implants (n = 6) and Group CeHA - apatite-coated Al2O3 implants (n = 6). The mineralization of the Al2O3 implants was analyzed in bone fragments using FT-Raman spectroscopy. Raman peaks at 959 cm-1 and 2940 cm-1 evaluated the inorganic and organic bone content, respectively. In vivo citotoxicity was analyzed using micronucleus test. Inorganic and organic content were higher in CeHA samples than in Ce and C (CeHA > Ce > C). FT-Raman spectroscopy showed that the higher the deposition of the organic matrix, more mineralization occurred. The micronucleus test showed that the uncoated and apatite-coated Al2O3 implants were non-cytotoxic and safe to in vivo applications.info:eu-repo/semantics/openAccessInstituto de Tecnologia do Paraná - TecparBrazilian Archives of Biology and Technology v.57 n.3 20142014-06-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132014000300004en10.1590/S1516-89132014005000002
institution SCIELO
collection OJS
country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author Maia Filho,Antonio Luiz Martins
Amaral,Fabrício Pires de Moura do
Martin,Airton Abrahão
Soares,Luís Eduardo Silva
spellingShingle Maia Filho,Antonio Luiz Martins
Amaral,Fabrício Pires de Moura do
Martin,Airton Abrahão
Soares,Luís Eduardo Silva
Evaluation of inorganic and organic bone components after application of an apatite-coated Al2O3 implants as scaffolds for bone repair
author_facet Maia Filho,Antonio Luiz Martins
Amaral,Fabrício Pires de Moura do
Martin,Airton Abrahão
Soares,Luís Eduardo Silva
author_sort Maia Filho,Antonio Luiz Martins
title Evaluation of inorganic and organic bone components after application of an apatite-coated Al2O3 implants as scaffolds for bone repair
title_short Evaluation of inorganic and organic bone components after application of an apatite-coated Al2O3 implants as scaffolds for bone repair
title_full Evaluation of inorganic and organic bone components after application of an apatite-coated Al2O3 implants as scaffolds for bone repair
title_fullStr Evaluation of inorganic and organic bone components after application of an apatite-coated Al2O3 implants as scaffolds for bone repair
title_full_unstemmed Evaluation of inorganic and organic bone components after application of an apatite-coated Al2O3 implants as scaffolds for bone repair
title_sort evaluation of inorganic and organic bone components after application of an apatite-coated al2o3 implants as scaffolds for bone repair
description The aim of this work was to study the influence of uncoated and apatite-coated Al2O3 implants on bone regeneration after 30 days of surgery in New Zealand white rabbits. Twelve samples of Al2O3 implants were prepared and half of them (n = 6) were apatite-coated by the modified biomimetic method. Three experimental groups were tested as Group C - control, surgery procedure without cerami c implant, Group Ce - uncoated Al 2O3 implants (n = 6) and Group CeHA - apatite-coated Al2O3 implants (n = 6). The mineralization of the Al2O3 implants was analyzed in bone fragments using FT-Raman spectroscopy. Raman peaks at 959 cm-1 and 2940 cm-1 evaluated the inorganic and organic bone content, respectively. In vivo citotoxicity was analyzed using micronucleus test. Inorganic and organic content were higher in CeHA samples than in Ce and C (CeHA > Ce > C). FT-Raman spectroscopy showed that the higher the deposition of the organic matrix, more mineralization occurred. The micronucleus test showed that the uncoated and apatite-coated Al2O3 implants were non-cytotoxic and safe to in vivo applications.
publisher Instituto de Tecnologia do Paraná - Tecpar
publishDate 2014
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132014000300004
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AT amaralfabriciopiresdemourado evaluationofinorganicandorganicbonecomponentsafterapplicationofanapatitecoatedal2o3implantsasscaffoldsforbonerepair
AT martinairtonabrahao evaluationofinorganicandorganicbonecomponentsafterapplicationofanapatitecoatedal2o3implantsasscaffoldsforbonerepair
AT soaresluiseduardosilva evaluationofinorganicandorganicbonecomponentsafterapplicationofanapatitecoatedal2o3implantsasscaffoldsforbonerepair
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