Systems biology approach to study the high altitude adaptation in tibetans

Systems biology approach to study the high altitude adaptation in tibetans

The aim of this work was to study an integrative systems biology research strategy to construct a network including the protein-protein interactions (PPIs) and microRNAs (miRNAs) and identify the functional biological processes and pathways for high-altitude adaptation in Tibetans. The pathway enrichment analysis revealed that the genes in the network were mainly involved in signling the pathways and the function of microRNAs was concentrated in the signling pathways, which suggested that miRNAs might contribute to the Tibetans high-altitude adaptation through the participation in signaling pathway. These results contribute to better understanding on the high-altitude adaptation of the Tibetans.

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Main Authors: De,Bi, Huajun,Xiao, Cuihong,Zhou, Jun,Zhou, Xiaoyan,Deng, Xiaopeng,Liu
Format: Digital revista
Language:English
Published: Instituto de Tecnologia do Paraná - Tecpar 2013
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132013000100007
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spelling oai:scielo:S1516-891320130001000072013-04-09Systems biology approach to study the high altitude adaptation in tibetansDe,BiHuajun,XiaoCuihong,ZhouJun,ZhouXiaoyan,DengXiaopeng,Liu systems biology Tibetan high-altitude adaptation single nucleotide polymorphism microRNA The aim of this work was to study an integrative systems biology research strategy to construct a network including the protein-protein interactions (PPIs) and microRNAs (miRNAs) and identify the functional biological processes and pathways for high-altitude adaptation in Tibetans. The pathway enrichment analysis revealed that the genes in the network were mainly involved in signling the pathways and the function of microRNAs was concentrated in the signling pathways, which suggested that miRNAs might contribute to the Tibetans high-altitude adaptation through the participation in signaling pathway. These results contribute to better understanding on the high-altitude adaptation of the Tibetans.info:eu-repo/semantics/openAccessInstituto de Tecnologia do Paraná - TecparBrazilian Archives of Biology and Technology v.56 n.1 20132013-02-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132013000100007en10.1590/S1516-89132013000100007
institution SCIELO
collection OJS
country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author De,Bi
Huajun,Xiao
Cuihong,Zhou
Jun,Zhou
Xiaoyan,Deng
Xiaopeng,Liu
spellingShingle De,Bi
Huajun,Xiao
Cuihong,Zhou
Jun,Zhou
Xiaoyan,Deng
Xiaopeng,Liu
Systems biology approach to study the high altitude adaptation in tibetans
author_facet De,Bi
Huajun,Xiao
Cuihong,Zhou
Jun,Zhou
Xiaoyan,Deng
Xiaopeng,Liu
author_sort De,Bi
title Systems biology approach to study the high altitude adaptation in tibetans
title_short Systems biology approach to study the high altitude adaptation in tibetans
title_full Systems biology approach to study the high altitude adaptation in tibetans
title_fullStr Systems biology approach to study the high altitude adaptation in tibetans
title_full_unstemmed Systems biology approach to study the high altitude adaptation in tibetans
title_sort systems biology approach to study the high altitude adaptation in tibetans
description The aim of this work was to study an integrative systems biology research strategy to construct a network including the protein-protein interactions (PPIs) and microRNAs (miRNAs) and identify the functional biological processes and pathways for high-altitude adaptation in Tibetans. The pathway enrichment analysis revealed that the genes in the network were mainly involved in signling the pathways and the function of microRNAs was concentrated in the signling pathways, which suggested that miRNAs might contribute to the Tibetans high-altitude adaptation through the participation in signaling pathway. These results contribute to better understanding on the high-altitude adaptation of the Tibetans.
publisher Instituto de Tecnologia do Paraná - Tecpar
publishDate 2013
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132013000100007
work_keys_str_mv AT debi systemsbiologyapproachtostudythehighaltitudeadaptationintibetans
AT huajunxiao systemsbiologyapproachtostudythehighaltitudeadaptationintibetans
AT cuihongzhou systemsbiologyapproachtostudythehighaltitudeadaptationintibetans
AT junzhou systemsbiologyapproachtostudythehighaltitudeadaptationintibetans
AT xiaoyandeng systemsbiologyapproachtostudythehighaltitudeadaptationintibetans
AT xiaopengliu systemsbiologyapproachtostudythehighaltitudeadaptationintibetans
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