Prevalence of estrogen receptor alpha PvuII (c454-397T>C) and XbaI (c454A>G) polymorphisms in a population of Brazilian women
The aim of this work was to study the estrogen receptor alpha (ERS1) PvuII and XbaI gene polymorphisms prevalence in randomly selected women population from Rio de Janeiro and Espírito Santo states in Brazil by polymerase chain reaction restriction fragment lengths polymorphism (PCR_RFLP) methodology. It was shown that Rio de Janeiro women exhibited a significantly different prevalence of XbaI polymorphism comparing to Espirito Santo women. Nonetheless, similar prevalence of PvuII polymorphism was found in both women´s populations. Moreover, a strong linkage disequilibrium was observed between these SNPs reinforcing the hypothesis of differential pattern of inheritance observed on such populations.
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Instituto de Tecnologia do Paraná - Tecpar
2011
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oai:scielo:S1516-891320110006000102011-12-13Prevalence of estrogen receptor alpha PvuII (c454-397T>C) and XbaI (c454A>G) polymorphisms in a population of Brazilian womenAraújo,Karine LourenzoneRezende,Lucas Cunha Dias deSouza,Letícia SonciniDaltoé,Renata DalmaschioMadeira,Klesia PirolaPaes,Marcela FerreiraHerkenhoff,Fernando LuizRangel,Letícia Batista AzevedoSilva,Ian Victor Polymorphism Estrogen Receptor Brazilian Women Prevalence Linkage disequilibrium The aim of this work was to study the estrogen receptor alpha (ERS1) PvuII and XbaI gene polymorphisms prevalence in randomly selected women population from Rio de Janeiro and Espírito Santo states in Brazil by polymerase chain reaction restriction fragment lengths polymorphism (PCR_RFLP) methodology. It was shown that Rio de Janeiro women exhibited a significantly different prevalence of XbaI polymorphism comparing to Espirito Santo women. Nonetheless, similar prevalence of PvuII polymorphism was found in both women´s populations. Moreover, a strong linkage disequilibrium was observed between these SNPs reinforcing the hypothesis of differential pattern of inheritance observed on such populations.info:eu-repo/semantics/openAccessInstituto de Tecnologia do Paraná - TecparBrazilian Archives of Biology and Technology v.54 n.6 20112011-12-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000600010en10.1590/S1516-89132011000600010 |
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Araújo,Karine Lourenzone Rezende,Lucas Cunha Dias de Souza,Letícia Soncini Daltoé,Renata Dalmaschio Madeira,Klesia Pirola Paes,Marcela Ferreira Herkenhoff,Fernando Luiz Rangel,Letícia Batista Azevedo Silva,Ian Victor |
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Araújo,Karine Lourenzone Rezende,Lucas Cunha Dias de Souza,Letícia Soncini Daltoé,Renata Dalmaschio Madeira,Klesia Pirola Paes,Marcela Ferreira Herkenhoff,Fernando Luiz Rangel,Letícia Batista Azevedo Silva,Ian Victor Prevalence of estrogen receptor alpha PvuII (c454-397T>C) and XbaI (c454A>G) polymorphisms in a population of Brazilian women |
author_facet |
Araújo,Karine Lourenzone Rezende,Lucas Cunha Dias de Souza,Letícia Soncini Daltoé,Renata Dalmaschio Madeira,Klesia Pirola Paes,Marcela Ferreira Herkenhoff,Fernando Luiz Rangel,Letícia Batista Azevedo Silva,Ian Victor |
author_sort |
Araújo,Karine Lourenzone |
title |
Prevalence of estrogen receptor alpha PvuII (c454-397T>C) and XbaI (c454A>G) polymorphisms in a population of Brazilian women |
title_short |
Prevalence of estrogen receptor alpha PvuII (c454-397T>C) and XbaI (c454A>G) polymorphisms in a population of Brazilian women |
title_full |
Prevalence of estrogen receptor alpha PvuII (c454-397T>C) and XbaI (c454A>G) polymorphisms in a population of Brazilian women |
title_fullStr |
Prevalence of estrogen receptor alpha PvuII (c454-397T>C) and XbaI (c454A>G) polymorphisms in a population of Brazilian women |
title_full_unstemmed |
Prevalence of estrogen receptor alpha PvuII (c454-397T>C) and XbaI (c454A>G) polymorphisms in a population of Brazilian women |
title_sort |
prevalence of estrogen receptor alpha pvuii (c454-397t>c) and xbai (c454a>g) polymorphisms in a population of brazilian women |
description |
The aim of this work was to study the estrogen receptor alpha (ERS1) PvuII and XbaI gene polymorphisms prevalence in randomly selected women population from Rio de Janeiro and Espírito Santo states in Brazil by polymerase chain reaction restriction fragment lengths polymorphism (PCR_RFLP) methodology. It was shown that Rio de Janeiro women exhibited a significantly different prevalence of XbaI polymorphism comparing to Espirito Santo women. Nonetheless, similar prevalence of PvuII polymorphism was found in both women´s populations. Moreover, a strong linkage disequilibrium was observed between these SNPs reinforcing the hypothesis of differential pattern of inheritance observed on such populations. |
publisher |
Instituto de Tecnologia do Paraná - Tecpar |
publishDate |
2011 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000600010 |
work_keys_str_mv |
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