Tumor growth characteristics of the Walker 256 AR tumor, a regressive variant of the rat Walker 256 A tumor

Tumor growth characteristics of the Walker 256 AR tumor, a regressive variant of the rat Walker 256 A tumor

The present study aimed at characterizing the subcutaneous development of the Walker 256 (W256) AR tumor, a regressive variant of the rat W256 A tumor. Wistar rats were injected subcutaneously with 4x10(6) W256 A or W256 AR tumor cells. The development of tumors was evaluated daily by percutaneous measurements. None of the W256 A tumors (n=20) regressed, but 62% of the W256 AR tumor-bearing rats (n=21) underwent complete tumor regression within 35 days. Continuous growth of AR tumors was characterized by an increase of the tumor growth rate from day 12, which reached values above 1.0 g/day, and were significantly higher (p<0.05) than those of the regressive AR tumors. Immunosuppression by irradiation before subcutaneous injection of AR cells completely abrogated tumor regression and was associated with severe metastatic dissemination. Daily evaluation of the tumor growth rate enabled the discrimination, in advance, between continuously growing tumors and those that regressed later on.

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Main Authors: Guimarães,Fernando, Schanoski,Alessandra Soares, Cavalcanti,Tereza Cristina Samico, Juliano,Priscila Bianchi, Viera-Matos,Ana Neuza, Rettori,Ovídio
Format: Digital revista
Language:English
Published: Instituto de Tecnologia do Paraná - Tecpar 2010
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132010000500014
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spelling oai:scielo:S1516-891320100005000142010-11-03Tumor growth characteristics of the Walker 256 AR tumor, a regressive variant of the rat Walker 256 A tumorGuimarães,FernandoSchanoski,Alessandra SoaresCavalcanti,Tereza Cristina SamicoJuliano,Priscila BianchiViera-Matos,Ana NeuzaRettori,Ovídio Tumor growth rate spontaneous tumor regression Wistar rats Walker 256 The present study aimed at characterizing the subcutaneous development of the Walker 256 (W256) AR tumor, a regressive variant of the rat W256 A tumor. Wistar rats were injected subcutaneously with 4x10(6) W256 A or W256 AR tumor cells. The development of tumors was evaluated daily by percutaneous measurements. None of the W256 A tumors (n=20) regressed, but 62% of the W256 AR tumor-bearing rats (n=21) underwent complete tumor regression within 35 days. Continuous growth of AR tumors was characterized by an increase of the tumor growth rate from day 12, which reached values above 1.0 g/day, and were significantly higher (p<0.05) than those of the regressive AR tumors. Immunosuppression by irradiation before subcutaneous injection of AR cells completely abrogated tumor regression and was associated with severe metastatic dissemination. Daily evaluation of the tumor growth rate enabled the discrimination, in advance, between continuously growing tumors and those that regressed later on.info:eu-repo/semantics/openAccessInstituto de Tecnologia do Paraná - TecparBrazilian Archives of Biology and Technology v.53 n.5 20102010-10-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132010000500014en10.1590/S1516-89132010000500014
institution SCIELO
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country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author Guimarães,Fernando
Schanoski,Alessandra Soares
Cavalcanti,Tereza Cristina Samico
Juliano,Priscila Bianchi
Viera-Matos,Ana Neuza
Rettori,Ovídio
spellingShingle Guimarães,Fernando
Schanoski,Alessandra Soares
Cavalcanti,Tereza Cristina Samico
Juliano,Priscila Bianchi
Viera-Matos,Ana Neuza
Rettori,Ovídio
Tumor growth characteristics of the Walker 256 AR tumor, a regressive variant of the rat Walker 256 A tumor
author_facet Guimarães,Fernando
Schanoski,Alessandra Soares
Cavalcanti,Tereza Cristina Samico
Juliano,Priscila Bianchi
Viera-Matos,Ana Neuza
Rettori,Ovídio
author_sort Guimarães,Fernando
title Tumor growth characteristics of the Walker 256 AR tumor, a regressive variant of the rat Walker 256 A tumor
title_short Tumor growth characteristics of the Walker 256 AR tumor, a regressive variant of the rat Walker 256 A tumor
title_full Tumor growth characteristics of the Walker 256 AR tumor, a regressive variant of the rat Walker 256 A tumor
title_fullStr Tumor growth characteristics of the Walker 256 AR tumor, a regressive variant of the rat Walker 256 A tumor
title_full_unstemmed Tumor growth characteristics of the Walker 256 AR tumor, a regressive variant of the rat Walker 256 A tumor
title_sort tumor growth characteristics of the walker 256 ar tumor, a regressive variant of the rat walker 256 a tumor
description The present study aimed at characterizing the subcutaneous development of the Walker 256 (W256) AR tumor, a regressive variant of the rat W256 A tumor. Wistar rats were injected subcutaneously with 4x10(6) W256 A or W256 AR tumor cells. The development of tumors was evaluated daily by percutaneous measurements. None of the W256 A tumors (n=20) regressed, but 62% of the W256 AR tumor-bearing rats (n=21) underwent complete tumor regression within 35 days. Continuous growth of AR tumors was characterized by an increase of the tumor growth rate from day 12, which reached values above 1.0 g/day, and were significantly higher (p<0.05) than those of the regressive AR tumors. Immunosuppression by irradiation before subcutaneous injection of AR cells completely abrogated tumor regression and was associated with severe metastatic dissemination. Daily evaluation of the tumor growth rate enabled the discrimination, in advance, between continuously growing tumors and those that regressed later on.
publisher Instituto de Tecnologia do Paraná - Tecpar
publishDate 2010
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132010000500014
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