Comparisons between continuous and batch processing to produce clavulanic acid by Streptomyces clavuligerus
The aim of the present work was to compare CA production in continuous culture with and without cell recycling and in batch process by Streptomyces clavuligerus. Continuous cultivations with high cell concentration using cell recycling were performed utilizing a hollow fiber ultrafiltration module to separate cells from the filtrate broth. The continuous cultures without cell recycling and the batch cultivations were performed conventionally. The highest productivity was attained in the continuous cultivation with cell recycling (22.2 mg.L-1.h-1). The highest CA concentration was obtained in the batch process (470 mg.L-1.h-1).
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Instituto de Tecnologia do Paraná - Tecpar
2005
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oai:scielo:S1516-891320050004000122005-08-15Comparisons between continuous and batch processing to produce clavulanic acid by Streptomyces clavuligerusBaptista-Neto,ÁlvaroTeodoro,Juliana ConceiçãoCassiano Filho,Luiz Claudio MacedoBadino,Alberto ColliHokka,Carlos Osamu Clavulanic acid Streptomyces clavuligerus continuous culture The aim of the present work was to compare CA production in continuous culture with and without cell recycling and in batch process by Streptomyces clavuligerus. Continuous cultivations with high cell concentration using cell recycling were performed utilizing a hollow fiber ultrafiltration module to separate cells from the filtrate broth. The continuous cultures without cell recycling and the batch cultivations were performed conventionally. The highest productivity was attained in the continuous cultivation with cell recycling (22.2 mg.L-1.h-1). The highest CA concentration was obtained in the batch process (470 mg.L-1.h-1).info:eu-repo/semantics/openAccessInstituto de Tecnologia do Paraná - TecparBrazilian Archives of Biology and Technology v.48 n.spe 20052005-06-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000400012en10.1590/S1516-89132005000400012 |
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Baptista-Neto,Álvaro Teodoro,Juliana Conceição Cassiano Filho,Luiz Claudio Macedo Badino,Alberto Colli Hokka,Carlos Osamu |
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Baptista-Neto,Álvaro Teodoro,Juliana Conceição Cassiano Filho,Luiz Claudio Macedo Badino,Alberto Colli Hokka,Carlos Osamu Comparisons between continuous and batch processing to produce clavulanic acid by Streptomyces clavuligerus |
| author_facet |
Baptista-Neto,Álvaro Teodoro,Juliana Conceição Cassiano Filho,Luiz Claudio Macedo Badino,Alberto Colli Hokka,Carlos Osamu |
| author_sort |
Baptista-Neto,Álvaro |
| title |
Comparisons between continuous and batch processing to produce clavulanic acid by Streptomyces clavuligerus |
| title_short |
Comparisons between continuous and batch processing to produce clavulanic acid by Streptomyces clavuligerus |
| title_full |
Comparisons between continuous and batch processing to produce clavulanic acid by Streptomyces clavuligerus |
| title_fullStr |
Comparisons between continuous and batch processing to produce clavulanic acid by Streptomyces clavuligerus |
| title_full_unstemmed |
Comparisons between continuous and batch processing to produce clavulanic acid by Streptomyces clavuligerus |
| title_sort |
comparisons between continuous and batch processing to produce clavulanic acid by streptomyces clavuligerus |
| description |
The aim of the present work was to compare CA production in continuous culture with and without cell recycling and in batch process by Streptomyces clavuligerus. Continuous cultivations with high cell concentration using cell recycling were performed utilizing a hollow fiber ultrafiltration module to separate cells from the filtrate broth. The continuous cultures without cell recycling and the batch cultivations were performed conventionally. The highest productivity was attained in the continuous cultivation with cell recycling (22.2 mg.L-1.h-1). The highest CA concentration was obtained in the batch process (470 mg.L-1.h-1). |
| publisher |
Instituto de Tecnologia do Paraná - Tecpar |
| publishDate |
2005 |
| url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132005000400012 |
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