Transmission of lupus anticoagulant by allogeneic stem cell transplantation

Passive transmission of autoimmune diseases by allogeneic stem cell transplantation is rare and is ascribed to passive transfer of memory B-cells from donor to recipient. We hereby report a case of transmission of an asymptomatic lupus anticoagulant from a sibling donor to a recipient of transplantation for secondary acute myeloid leukemia. On pre-harvest evaluation, the sibling donor with no history of bleeding or thrombosis was found to have a lupus anticoagulant. After engraftment, the recipient was found to have a new prolonged activated partial thromboplastin time and was subsequently shown to have a lupus anticoagulant on Day +73 after stem cell transplantation. The recipient remained well with no evidence of bleeding, thrombosis, or graft-versus-host disease and was on a stable dose of tacrolimus at the time the lupus anticoagulant was detected. There was no other identifiable trigger for the appearance of a lupus anticoagulant.

Bibliographic Details

Main Authors:	Massoud,Mira Romany, William,Basem M., Harrill,Katrina, Cooper,Brenda Wimpfheimer, Lima,Marcos de, Schmaier,Alvin H.
Format:	Digital revista
Language:	English
Published:	Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular 2014
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842014000400287
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