Brazilian Guidelines for transcranial doppler in children and adolescents with sickle cell disease
BACKGROUND: Sickle cell disease is the most common monogenic hereditary disease in Brazil. Although strokes are one of the main causes of morbidity and mortality in these patients, the use of transcranial Doppler to identify children at risk is not universally used. OBJECTIVE: To develop Brazilian guidelines for the use of transcranial Doppler in sickle cell disease children and adolescents, so that related health policies can be expanded, and thus contribute to reduce morbidity and mortality. METHODS: The guidelines were formulated in a consensus meeting of experts in transcranial Doppler and sickle cell disease. The issues discussed were previously formulated and scientific articles in databases (MEDLINE, SciELO and Cochrane) were carefully analyzed. The consensus for each question was obtained by a vote of experts on the specific theme. RESULTS: Recommendations were made, including indications for the use of transcranial Doppler according to the sickle cell disease genotype and patients age; the necessary conditions to perform the exam and its periodicity depending on exam results; the criteria for the indication of blood transfusions and iron chelation therapy; the indication of hydroxyurea; and the therapeutic approach in cases of conditional transcranial Doppler. CONCLUSION: The Brazilian guidelines on the use of transcranial doppler in sickle cell disease patients may reduce the risk of strokes, and thus reduce the morbidity and mortality and improve the quality of life of sickle cell disease patients.
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Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular
2011
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oai:scielo:S1516-848420110001000142011-05-05Brazilian Guidelines for transcranial doppler in children and adolescents with sickle cell diseaseLobo,Clarisse Lopes de CastroCançado,Rodolfo DelfiniLeite,Ana Claudia Celestino BezerraAnjos,Ana Claudia Mendonça dosPinto,Ana Cristina SilvaMatta,Andre Palma da CunhaSilva,Célia MariaSilva,Gisele SampaioFriedrisch,João RicardoBraga,Josefina Aparecida PellegriniLange,Marcos ChristianoFigueiredo,Maria StellaRugani,Marília ÁlvaresVeloso,OrlandoMoura,Patrícia GomesCortez,Paulo IvoAdams,RobertGualandro,Sandra Fátima MenosiCastilho,Shirley Lopes deThomé,UrsulaZetola,Viviane Flumignan Ultrasonography, doppler, transcranial/methods Anemia, sickle cell/diagnosis Anemia, sickle cell/therapy Hemoglobin/sickle Stroke/prevention & control Child Adolescent Guideline BACKGROUND: Sickle cell disease is the most common monogenic hereditary disease in Brazil. Although strokes are one of the main causes of morbidity and mortality in these patients, the use of transcranial Doppler to identify children at risk is not universally used. OBJECTIVE: To develop Brazilian guidelines for the use of transcranial Doppler in sickle cell disease children and adolescents, so that related health policies can be expanded, and thus contribute to reduce morbidity and mortality. METHODS: The guidelines were formulated in a consensus meeting of experts in transcranial Doppler and sickle cell disease. The issues discussed were previously formulated and scientific articles in databases (MEDLINE, SciELO and Cochrane) were carefully analyzed. The consensus for each question was obtained by a vote of experts on the specific theme. RESULTS: Recommendations were made, including indications for the use of transcranial Doppler according to the sickle cell disease genotype and patients age; the necessary conditions to perform the exam and its periodicity depending on exam results; the criteria for the indication of blood transfusions and iron chelation therapy; the indication of hydroxyurea; and the therapeutic approach in cases of conditional transcranial Doppler. CONCLUSION: The Brazilian guidelines on the use of transcranial doppler in sickle cell disease patients may reduce the risk of strokes, and thus reduce the morbidity and mortality and improve the quality of life of sickle cell disease patients.info:eu-repo/semantics/openAccessAssociação Brasileira de Hematologia e Hemoterapia e Terapia CelularRevista Brasileira de Hematologia e Hemoterapia v.33 n.1 20112011-02-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842011000100014en10.5581/1516-8484.20110014 |
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Lobo,Clarisse Lopes de Castro Cançado,Rodolfo Delfini Leite,Ana Claudia Celestino Bezerra Anjos,Ana Claudia Mendonça dos Pinto,Ana Cristina Silva Matta,Andre Palma da Cunha Silva,Célia Maria Silva,Gisele Sampaio Friedrisch,João Ricardo Braga,Josefina Aparecida Pellegrini Lange,Marcos Christiano Figueiredo,Maria Stella Rugani,Marília Álvares Veloso,Orlando Moura,Patrícia Gomes Cortez,Paulo Ivo Adams,Robert Gualandro,Sandra Fátima Menosi Castilho,Shirley Lopes de Thomé,Ursula Zetola,Viviane Flumignan |
spellingShingle |
Lobo,Clarisse Lopes de Castro Cançado,Rodolfo Delfini Leite,Ana Claudia Celestino Bezerra Anjos,Ana Claudia Mendonça dos Pinto,Ana Cristina Silva Matta,Andre Palma da Cunha Silva,Célia Maria Silva,Gisele Sampaio Friedrisch,João Ricardo Braga,Josefina Aparecida Pellegrini Lange,Marcos Christiano Figueiredo,Maria Stella Rugani,Marília Álvares Veloso,Orlando Moura,Patrícia Gomes Cortez,Paulo Ivo Adams,Robert Gualandro,Sandra Fátima Menosi Castilho,Shirley Lopes de Thomé,Ursula Zetola,Viviane Flumignan Brazilian Guidelines for transcranial doppler in children and adolescents with sickle cell disease |
author_facet |
Lobo,Clarisse Lopes de Castro Cançado,Rodolfo Delfini Leite,Ana Claudia Celestino Bezerra Anjos,Ana Claudia Mendonça dos Pinto,Ana Cristina Silva Matta,Andre Palma da Cunha Silva,Célia Maria Silva,Gisele Sampaio Friedrisch,João Ricardo Braga,Josefina Aparecida Pellegrini Lange,Marcos Christiano Figueiredo,Maria Stella Rugani,Marília Álvares Veloso,Orlando Moura,Patrícia Gomes Cortez,Paulo Ivo Adams,Robert Gualandro,Sandra Fátima Menosi Castilho,Shirley Lopes de Thomé,Ursula Zetola,Viviane Flumignan |
author_sort |
Lobo,Clarisse Lopes de Castro |
title |
Brazilian Guidelines for transcranial doppler in children and adolescents with sickle cell disease |
title_short |
Brazilian Guidelines for transcranial doppler in children and adolescents with sickle cell disease |
title_full |
Brazilian Guidelines for transcranial doppler in children and adolescents with sickle cell disease |
title_fullStr |
Brazilian Guidelines for transcranial doppler in children and adolescents with sickle cell disease |
title_full_unstemmed |
Brazilian Guidelines for transcranial doppler in children and adolescents with sickle cell disease |
title_sort |
brazilian guidelines for transcranial doppler in children and adolescents with sickle cell disease |
description |
BACKGROUND: Sickle cell disease is the most common monogenic hereditary disease in Brazil. Although strokes are one of the main causes of morbidity and mortality in these patients, the use of transcranial Doppler to identify children at risk is not universally used. OBJECTIVE: To develop Brazilian guidelines for the use of transcranial Doppler in sickle cell disease children and adolescents, so that related health policies can be expanded, and thus contribute to reduce morbidity and mortality. METHODS: The guidelines were formulated in a consensus meeting of experts in transcranial Doppler and sickle cell disease. The issues discussed were previously formulated and scientific articles in databases (MEDLINE, SciELO and Cochrane) were carefully analyzed. The consensus for each question was obtained by a vote of experts on the specific theme. RESULTS: Recommendations were made, including indications for the use of transcranial Doppler according to the sickle cell disease genotype and patients age; the necessary conditions to perform the exam and its periodicity depending on exam results; the criteria for the indication of blood transfusions and iron chelation therapy; the indication of hydroxyurea; and the therapeutic approach in cases of conditional transcranial Doppler. CONCLUSION: The Brazilian guidelines on the use of transcranial doppler in sickle cell disease patients may reduce the risk of strokes, and thus reduce the morbidity and mortality and improve the quality of life of sickle cell disease patients. |
publisher |
Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular |
publishDate |
2011 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842011000100014 |
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