Differentiation syndrome in acute promyelocytic leukemia: pathogenesis and risk factors

Differentiation syndrome in acute promyelocytic leukemia: pathogenesis and risk factors

Differentiation syndrome is a treatment complication which can occur in acute promyelocytic leukemia (APL) patients treated with all-trans retinoic acid (ATRA) or arsenic trioxide (ATO), which is characterized by enhanced leukocyte transmigration. Several cellular and molecular mechanisms participate in differentiation syndrome development. This review discusses the changes in expression of adhesion molecules induced during ATRA and ATO treatments and their possible implications in the pathogenesis of this potentially fatal complication.

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Main Authors: Rego,Eduardo M., Santana-Lemos,Bárbara A. A., Tamarozzi,Mirela B.
Format: Digital revista
Language:English
Published: Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular 2008
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842008000800009
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spelling oai:scielo:S1516-848420080008000092008-12-09Differentiation syndrome in acute promyelocytic leukemia: pathogenesis and risk factorsRego,Eduardo M.Santana-Lemos,Bárbara A. A.Tamarozzi,Mirela B. Acute promyelocytic leukemia adhesion molecules retinoids arsenic trioxide Differentiation syndrome is a treatment complication which can occur in acute promyelocytic leukemia (APL) patients treated with all-trans retinoic acid (ATRA) or arsenic trioxide (ATO), which is characterized by enhanced leukocyte transmigration. Several cellular and molecular mechanisms participate in differentiation syndrome development. This review discusses the changes in expression of adhesion molecules induced during ATRA and ATO treatments and their possible implications in the pathogenesis of this potentially fatal complication.info:eu-repo/semantics/openAccessAssociação Brasileira de Hematologia e Hemoterapia e Terapia CelularRevista Brasileira de Hematologia e Hemoterapia v.30 suppl.2 20082008-06-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842008000800009en10.1590/S1516-84842008000800009
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country Brasil
countrycode BR
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access En linea
databasecode rev-scielo-br
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author Rego,Eduardo M.
Santana-Lemos,Bárbara A. A.
Tamarozzi,Mirela B.
spellingShingle Rego,Eduardo M.
Santana-Lemos,Bárbara A. A.
Tamarozzi,Mirela B.
Differentiation syndrome in acute promyelocytic leukemia: pathogenesis and risk factors
author_facet Rego,Eduardo M.
Santana-Lemos,Bárbara A. A.
Tamarozzi,Mirela B.
author_sort Rego,Eduardo M.
title Differentiation syndrome in acute promyelocytic leukemia: pathogenesis and risk factors
title_short Differentiation syndrome in acute promyelocytic leukemia: pathogenesis and risk factors
title_full Differentiation syndrome in acute promyelocytic leukemia: pathogenesis and risk factors
title_fullStr Differentiation syndrome in acute promyelocytic leukemia: pathogenesis and risk factors
title_full_unstemmed Differentiation syndrome in acute promyelocytic leukemia: pathogenesis and risk factors
title_sort differentiation syndrome in acute promyelocytic leukemia: pathogenesis and risk factors
description Differentiation syndrome is a treatment complication which can occur in acute promyelocytic leukemia (APL) patients treated with all-trans retinoic acid (ATRA) or arsenic trioxide (ATO), which is characterized by enhanced leukocyte transmigration. Several cellular and molecular mechanisms participate in differentiation syndrome development. This review discusses the changes in expression of adhesion molecules induced during ATRA and ATO treatments and their possible implications in the pathogenesis of this potentially fatal complication.
publisher Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular
publishDate 2008
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842008000800009
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AT santanalemosbarbaraaa differentiationsyndromeinacutepromyelocyticleukemiapathogenesisandriskfactors
AT tamarozzimirelab differentiationsyndromeinacutepromyelocyticleukemiapathogenesisandriskfactors
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