Acute myeloid leukemia with t(8;21)(q22;q22) preceded by breast granulocytic sarcoma

Acute myeloid leukemia with t(8;21)(q22;q22) preceded by breast granulocytic sarcoma

Granulocytic sarcoma (GS) is a rare extramedullary tumor mass composed of immature cells derived from the hematopoietic myeloid series. It is usually associated with leukemia and other myeloproliferative disorders but can also occur without overt hematologic diseases. The breast has been reported to be an uncommon site of presentation. We report a case of acute myeloid leukemia preceded by GS of the breast. The immunohistochemistry revealed myeloperoxidase, CD68 and CD43 positivity, thus indicating a diagnosis of GS. Conventional cytogenetic analysis of peripheral blood cells showed t(8;21)(q22;22). Complete remission was achieved with Daunorubicin and Cytarabine induction therapy followed by three courses of high-dose Cytarabine consolidation. The patient remains in continuous complete remission at 27 months.

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Main Authors: Rocha Filho,Francisco D., Lima,Gabrielle G., Ferreira,Francisco V., Miranda,Nadjane B. A., Santos,Franklin J. C., Vieira,Andrea A., Messias,Nídia C.
Format: Digital revista
Language:English
Published: Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular 2008
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842008000500020
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spelling oai:scielo:S1516-848420080005000202008-12-16Acute myeloid leukemia with t(8;21)(q22;q22) preceded by breast granulocytic sarcomaRocha Filho,Francisco D.Lima,Gabrielle G.Ferreira,Francisco V.Miranda,Nadjane B. A.Santos,Franklin J. C.Vieira,Andrea A.Messias,Nídia C. Granulocytic sarcoma breast acute myeloid leukemia Granulocytic sarcoma (GS) is a rare extramedullary tumor mass composed of immature cells derived from the hematopoietic myeloid series. It is usually associated with leukemia and other myeloproliferative disorders but can also occur without overt hematologic diseases. The breast has been reported to be an uncommon site of presentation. We report a case of acute myeloid leukemia preceded by GS of the breast. The immunohistochemistry revealed myeloperoxidase, CD68 and CD43 positivity, thus indicating a diagnosis of GS. Conventional cytogenetic analysis of peripheral blood cells showed t(8;21)(q22;22). Complete remission was achieved with Daunorubicin and Cytarabine induction therapy followed by three courses of high-dose Cytarabine consolidation. The patient remains in continuous complete remission at 27 months.info:eu-repo/semantics/openAccessAssociação Brasileira de Hematologia e Hemoterapia e Terapia CelularRevista Brasileira de Hematologia e Hemoterapia v.30 n.5 20082008-10-01info:eu-repo/semantics/reporttext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842008000500020en10.1590/S1516-84842008000500020
institution SCIELO
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country Brasil
countrycode BR
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libraryname SciELO
language English
format Digital
author Rocha Filho,Francisco D.
Lima,Gabrielle G.
Ferreira,Francisco V.
Miranda,Nadjane B. A.
Santos,Franklin J. C.
Vieira,Andrea A.
Messias,Nídia C.
spellingShingle Rocha Filho,Francisco D.
Lima,Gabrielle G.
Ferreira,Francisco V.
Miranda,Nadjane B. A.
Santos,Franklin J. C.
Vieira,Andrea A.
Messias,Nídia C.
Acute myeloid leukemia with t(8;21)(q22;q22) preceded by breast granulocytic sarcoma
author_facet Rocha Filho,Francisco D.
Lima,Gabrielle G.
Ferreira,Francisco V.
Miranda,Nadjane B. A.
Santos,Franklin J. C.
Vieira,Andrea A.
Messias,Nídia C.
author_sort Rocha Filho,Francisco D.
title Acute myeloid leukemia with t(8;21)(q22;q22) preceded by breast granulocytic sarcoma
title_short Acute myeloid leukemia with t(8;21)(q22;q22) preceded by breast granulocytic sarcoma
title_full Acute myeloid leukemia with t(8;21)(q22;q22) preceded by breast granulocytic sarcoma
title_fullStr Acute myeloid leukemia with t(8;21)(q22;q22) preceded by breast granulocytic sarcoma
title_full_unstemmed Acute myeloid leukemia with t(8;21)(q22;q22) preceded by breast granulocytic sarcoma
title_sort acute myeloid leukemia with t(8;21)(q22;q22) preceded by breast granulocytic sarcoma
description Granulocytic sarcoma (GS) is a rare extramedullary tumor mass composed of immature cells derived from the hematopoietic myeloid series. It is usually associated with leukemia and other myeloproliferative disorders but can also occur without overt hematologic diseases. The breast has been reported to be an uncommon site of presentation. We report a case of acute myeloid leukemia preceded by GS of the breast. The immunohistochemistry revealed myeloperoxidase, CD68 and CD43 positivity, thus indicating a diagnosis of GS. Conventional cytogenetic analysis of peripheral blood cells showed t(8;21)(q22;22). Complete remission was achieved with Daunorubicin and Cytarabine induction therapy followed by three courses of high-dose Cytarabine consolidation. The patient remains in continuous complete remission at 27 months.
publisher Associação Brasileira de Hematologia e Hemoterapia e Terapia Celular
publishDate 2008
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842008000500020
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