Aspectos neuroquímicos: o papel da serotonina no TOC

Aspectos neuroquímicos: o papel da serotonina no TOC

The therapeutic action of selective serotonin (5-HT) reuptake inhibitors (SSRIs) in obsessive-compulsive disorder (OCD) points to the role of 5-HT in this condition. Functional neuroimaging studies showed hyperactivity of the nucleus caudatum in OCD patients, which disappears following treatment with either SSRIs or cognitive behavior therapy. Pharmacological results indicate hypersensitivity of the 5-HT1D receptor subtype in OCD, similarly reversed by chronic administration of SSRIs. Neurochemical data show that these receptors are selectively concentrated in the striatum, and are localized in 5-HT terminals, where they inhibit 5-HT release by the nerve impulse. Since 5-HT reduces the activity of post-synaptic neurons in the striatum, it has been suggested that the hypersensitivity of 5-HT1D receptors contribute to the genesis of OCD symptoms.

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Main Author: Graeff,Frederico G
Format: Digital revista
Language:Portuguese
Published: Associação Brasileira de Psiquiatria 2001
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462001000600011
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spelling oai:scielo:S1516-444620010006000112001-12-11Aspectos neuroquímicos: o papel da serotonina no TOCGraeff,Frederico G Obsessive-compulsive disorder Receptors Serotonin The therapeutic action of selective serotonin (5-HT) reuptake inhibitors (SSRIs) in obsessive-compulsive disorder (OCD) points to the role of 5-HT in this condition. Functional neuroimaging studies showed hyperactivity of the nucleus caudatum in OCD patients, which disappears following treatment with either SSRIs or cognitive behavior therapy. Pharmacological results indicate hypersensitivity of the 5-HT1D receptor subtype in OCD, similarly reversed by chronic administration of SSRIs. Neurochemical data show that these receptors are selectively concentrated in the striatum, and are localized in 5-HT terminals, where they inhibit 5-HT release by the nerve impulse. Since 5-HT reduces the activity of post-synaptic neurons in the striatum, it has been suggested that the hypersensitivity of 5-HT1D receptors contribute to the genesis of OCD symptoms.info:eu-repo/semantics/openAccessAssociação Brasileira de PsiquiatriaBrazilian Journal of Psychiatry v.23 suppl.2 20012001-10-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462001000600011pt10.1590/S1516-44462001000600011
institution SCIELO
collection OJS
country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
tag revista
region America del Sur
libraryname SciELO
language Portuguese
format Digital
author Graeff,Frederico G
spellingShingle Graeff,Frederico G
Aspectos neuroquímicos: o papel da serotonina no TOC
author_facet Graeff,Frederico G
author_sort Graeff,Frederico G
title Aspectos neuroquímicos: o papel da serotonina no TOC
title_short Aspectos neuroquímicos: o papel da serotonina no TOC
title_full Aspectos neuroquímicos: o papel da serotonina no TOC
title_fullStr Aspectos neuroquímicos: o papel da serotonina no TOC
title_full_unstemmed Aspectos neuroquímicos: o papel da serotonina no TOC
title_sort aspectos neuroquímicos: o papel da serotonina no toc
description The therapeutic action of selective serotonin (5-HT) reuptake inhibitors (SSRIs) in obsessive-compulsive disorder (OCD) points to the role of 5-HT in this condition. Functional neuroimaging studies showed hyperactivity of the nucleus caudatum in OCD patients, which disappears following treatment with either SSRIs or cognitive behavior therapy. Pharmacological results indicate hypersensitivity of the 5-HT1D receptor subtype in OCD, similarly reversed by chronic administration of SSRIs. Neurochemical data show that these receptors are selectively concentrated in the striatum, and are localized in 5-HT terminals, where they inhibit 5-HT release by the nerve impulse. Since 5-HT reduces the activity of post-synaptic neurons in the striatum, it has been suggested that the hypersensitivity of 5-HT1D receptors contribute to the genesis of OCD symptoms.
publisher Associação Brasileira de Psiquiatria
publishDate 2001
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-44462001000600011
work_keys_str_mv AT graefffredericog aspectosneuroquimicosopapeldaserotoninanotoc
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