Association between vitamin D levels and lower-extremity deep vein thrombosis: a case-control study
ABSTRACT BACKGROUND: Vitamin D has relationships with pathogenesis and inflammation pathways in many diseases. Its deficiency may make clinicians think not only of supplementation but also of presence of other diseases. OBJECTIVE: To investigate the relationship between vitamin D levels and deep vein thrombosis (DVT), given that reduced levels are related to increased risk of cardiovascular diseases. DESIGN AND SETTING: Case-control study conducted in the cardiovascular surgery and family medicine departments of a hospital in Turkey. METHODS: A total of 280 participants were included: 140 each in the DVT and control groups. Basic clinical characteristics, comorbidities and serum 25-hydroxyvitamin D (25(OH)D) levels were recorded and then compared between the groups. Serum 25(OH)D levels were also evaluated separately in three subgroups (sufficient, insufficient and deficient). RESULTS: Serum 25(OH)D levels were significantly lower in the DVT group than in the controls (P < 0.001). Females in the DVT group had lower 25(OH)D levels than those in the control group (P = 0.002). Nonetheless, the median 25(OH)D level (16.41 ng/ml) of the control group was still below the reference value. Logistic regression analysis showed that 25(OH)D was a significant predictor of DVT. Weight, height and body mass index, which all presented interaction, were significant in the logistic regression analysis but not in individual analyses. CONCLUSION: The serum vitamin D levels of DVT patients were lower than those of controls. If the results obtained from our study are supported by further large-scale randomized controlled trials, vitamin D replacement may be brought into the agenda for protection against DVT.
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Associação Paulista de Medicina - APM
2021
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oai:scielo:S1516-318020210003002792021-05-26Association between vitamin D levels and lower-extremity deep vein thrombosis: a case-control studyKorkmaz,Ufuk Turan KursatErsoy,SuleymanYuksel,AhmetCelik,HumeyraUcaroglu,Erhan RenanVelioglu,YusufCetinkaya,AyhanDemir,DenizEsen,UmutErdem,Kemalettin Vitamin D Venous thrombosis 25-hydroxyvitamin D3 1-alpha-hydroxylase Deep vein thrombosis Deep venous thromboses 25(OH)D 25-hydroxyvitamin D3 Thrombosis, deep vein ABSTRACT BACKGROUND: Vitamin D has relationships with pathogenesis and inflammation pathways in many diseases. Its deficiency may make clinicians think not only of supplementation but also of presence of other diseases. OBJECTIVE: To investigate the relationship between vitamin D levels and deep vein thrombosis (DVT), given that reduced levels are related to increased risk of cardiovascular diseases. DESIGN AND SETTING: Case-control study conducted in the cardiovascular surgery and family medicine departments of a hospital in Turkey. METHODS: A total of 280 participants were included: 140 each in the DVT and control groups. Basic clinical characteristics, comorbidities and serum 25-hydroxyvitamin D (25(OH)D) levels were recorded and then compared between the groups. Serum 25(OH)D levels were also evaluated separately in three subgroups (sufficient, insufficient and deficient). RESULTS: Serum 25(OH)D levels were significantly lower in the DVT group than in the controls (P < 0.001). Females in the DVT group had lower 25(OH)D levels than those in the control group (P = 0.002). Nonetheless, the median 25(OH)D level (16.41 ng/ml) of the control group was still below the reference value. Logistic regression analysis showed that 25(OH)D was a significant predictor of DVT. Weight, height and body mass index, which all presented interaction, were significant in the logistic regression analysis but not in individual analyses. CONCLUSION: The serum vitamin D levels of DVT patients were lower than those of controls. If the results obtained from our study are supported by further large-scale randomized controlled trials, vitamin D replacement may be brought into the agenda for protection against DVT.info:eu-repo/semantics/openAccessAssociação Paulista de Medicina - APMSao Paulo Medical Journal v.139 n.3 20212021-06-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802021000300279en10.1590/1516-3180.2020.0457.r1.04022021 |
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Korkmaz,Ufuk Turan Kursat Ersoy,Suleyman Yuksel,Ahmet Celik,Humeyra Ucaroglu,Erhan Renan Velioglu,Yusuf Cetinkaya,Ayhan Demir,Deniz Esen,Umut Erdem,Kemalettin |
| spellingShingle |
Korkmaz,Ufuk Turan Kursat Ersoy,Suleyman Yuksel,Ahmet Celik,Humeyra Ucaroglu,Erhan Renan Velioglu,Yusuf Cetinkaya,Ayhan Demir,Deniz Esen,Umut Erdem,Kemalettin Association between vitamin D levels and lower-extremity deep vein thrombosis: a case-control study |
| author_facet |
Korkmaz,Ufuk Turan Kursat Ersoy,Suleyman Yuksel,Ahmet Celik,Humeyra Ucaroglu,Erhan Renan Velioglu,Yusuf Cetinkaya,Ayhan Demir,Deniz Esen,Umut Erdem,Kemalettin |
| author_sort |
Korkmaz,Ufuk Turan Kursat |
| title |
Association between vitamin D levels and lower-extremity deep vein thrombosis: a case-control study |
| title_short |
Association between vitamin D levels and lower-extremity deep vein thrombosis: a case-control study |
| title_full |
Association between vitamin D levels and lower-extremity deep vein thrombosis: a case-control study |
| title_fullStr |
Association between vitamin D levels and lower-extremity deep vein thrombosis: a case-control study |
| title_full_unstemmed |
Association between vitamin D levels and lower-extremity deep vein thrombosis: a case-control study |
| title_sort |
association between vitamin d levels and lower-extremity deep vein thrombosis: a case-control study |
| description |
ABSTRACT BACKGROUND: Vitamin D has relationships with pathogenesis and inflammation pathways in many diseases. Its deficiency may make clinicians think not only of supplementation but also of presence of other diseases. OBJECTIVE: To investigate the relationship between vitamin D levels and deep vein thrombosis (DVT), given that reduced levels are related to increased risk of cardiovascular diseases. DESIGN AND SETTING: Case-control study conducted in the cardiovascular surgery and family medicine departments of a hospital in Turkey. METHODS: A total of 280 participants were included: 140 each in the DVT and control groups. Basic clinical characteristics, comorbidities and serum 25-hydroxyvitamin D (25(OH)D) levels were recorded and then compared between the groups. Serum 25(OH)D levels were also evaluated separately in three subgroups (sufficient, insufficient and deficient). RESULTS: Serum 25(OH)D levels were significantly lower in the DVT group than in the controls (P < 0.001). Females in the DVT group had lower 25(OH)D levels than those in the control group (P = 0.002). Nonetheless, the median 25(OH)D level (16.41 ng/ml) of the control group was still below the reference value. Logistic regression analysis showed that 25(OH)D was a significant predictor of DVT. Weight, height and body mass index, which all presented interaction, were significant in the logistic regression analysis but not in individual analyses. CONCLUSION: The serum vitamin D levels of DVT patients were lower than those of controls. If the results obtained from our study are supported by further large-scale randomized controlled trials, vitamin D replacement may be brought into the agenda for protection against DVT. |
| publisher |
Associação Paulista de Medicina - APM |
| publishDate |
2021 |
| url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802021000300279 |
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