Complex karyotype including ring chromosome 11 in a patient with acute myeloid leukemia: case report
ABSTRACT CONTEXT: Complex karyotypes in acute myeloid leukemia (AML) are characterized by an overall low response rate with frequent relapses after clinical treatment. CASE REPORT: Here, we describe the case of a 61-year-old obese female with clinically diagnosed AML who presented a complex karyotype involving an uncommon abnormality: ring chromosome 11. Immunophenotypic analysis confirmed the diagnosis. Classical and molecular cytogenetic analyses, using GTG banding and FISH (fluorescence in situ hybridization), revealed the presence of complex structural rearrangement involving r(11), add(12)(p13), der(5) and der(13). CONCLUSIONS: Molecular cytogenetic analysis is suitable for better identification and characterization of chromosomal rearrangements in AML. Case reports like this, as well as population-based studies, are necessary for understanding the karyotypic changes that occur in humans.
Main Authors: | , , , , , , , , |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Associação Paulista de Medicina - APM
2018
|
Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802018000400361 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
oai:scielo:S1516-31802018000400361 |
---|---|
record_format |
ojs |
spelling |
oai:scielo:S1516-318020180004003612018-09-18Complex karyotype including ring chromosome 11 in a patient with acute myeloid leukemia: case reportOrnellas,Maria Helena FariaMaioli,Maria Christina PaixãoLucena,Stella Beatriz Sampaio Gonçalves deBastos,Elenice FerreiraChaves,Tatiana SilvaMelo,Karina Vieira deRibeiro-Carvalho,Marilza de MouraLiehr,ThomasAlves,Gilda Leukemia, myeloid, acute Leukemia Obesity Chromosome aberrations Cytogenetic analysis ABSTRACT CONTEXT: Complex karyotypes in acute myeloid leukemia (AML) are characterized by an overall low response rate with frequent relapses after clinical treatment. CASE REPORT: Here, we describe the case of a 61-year-old obese female with clinically diagnosed AML who presented a complex karyotype involving an uncommon abnormality: ring chromosome 11. Immunophenotypic analysis confirmed the diagnosis. Classical and molecular cytogenetic analyses, using GTG banding and FISH (fluorescence in situ hybridization), revealed the presence of complex structural rearrangement involving r(11), add(12)(p13), der(5) and der(13). CONCLUSIONS: Molecular cytogenetic analysis is suitable for better identification and characterization of chromosomal rearrangements in AML. Case reports like this, as well as population-based studies, are necessary for understanding the karyotypic changes that occur in humans.info:eu-repo/semantics/openAccessAssociação Paulista de Medicina - APMSao Paulo Medical Journal v.136 n.4 20182018-08-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802018000400361en10.1590/1516-3180.2016.0252150217 |
institution |
SCIELO |
collection |
OJS |
country |
Brasil |
countrycode |
BR |
component |
Revista |
access |
En linea |
databasecode |
rev-scielo-br |
tag |
revista |
region |
America del Sur |
libraryname |
SciELO |
language |
English |
format |
Digital |
author |
Ornellas,Maria Helena Faria Maioli,Maria Christina Paixão Lucena,Stella Beatriz Sampaio Gonçalves de Bastos,Elenice Ferreira Chaves,Tatiana Silva Melo,Karina Vieira de Ribeiro-Carvalho,Marilza de Moura Liehr,Thomas Alves,Gilda |
spellingShingle |
Ornellas,Maria Helena Faria Maioli,Maria Christina Paixão Lucena,Stella Beatriz Sampaio Gonçalves de Bastos,Elenice Ferreira Chaves,Tatiana Silva Melo,Karina Vieira de Ribeiro-Carvalho,Marilza de Moura Liehr,Thomas Alves,Gilda Complex karyotype including ring chromosome 11 in a patient with acute myeloid leukemia: case report |
author_facet |
Ornellas,Maria Helena Faria Maioli,Maria Christina Paixão Lucena,Stella Beatriz Sampaio Gonçalves de Bastos,Elenice Ferreira Chaves,Tatiana Silva Melo,Karina Vieira de Ribeiro-Carvalho,Marilza de Moura Liehr,Thomas Alves,Gilda |
author_sort |
Ornellas,Maria Helena Faria |
title |
Complex karyotype including ring chromosome 11 in a patient with acute myeloid leukemia: case report |
title_short |
Complex karyotype including ring chromosome 11 in a patient with acute myeloid leukemia: case report |
title_full |
Complex karyotype including ring chromosome 11 in a patient with acute myeloid leukemia: case report |
title_fullStr |
Complex karyotype including ring chromosome 11 in a patient with acute myeloid leukemia: case report |
title_full_unstemmed |
Complex karyotype including ring chromosome 11 in a patient with acute myeloid leukemia: case report |
title_sort |
complex karyotype including ring chromosome 11 in a patient with acute myeloid leukemia: case report |
description |
ABSTRACT CONTEXT: Complex karyotypes in acute myeloid leukemia (AML) are characterized by an overall low response rate with frequent relapses after clinical treatment. CASE REPORT: Here, we describe the case of a 61-year-old obese female with clinically diagnosed AML who presented a complex karyotype involving an uncommon abnormality: ring chromosome 11. Immunophenotypic analysis confirmed the diagnosis. Classical and molecular cytogenetic analyses, using GTG banding and FISH (fluorescence in situ hybridization), revealed the presence of complex structural rearrangement involving r(11), add(12)(p13), der(5) and der(13). CONCLUSIONS: Molecular cytogenetic analysis is suitable for better identification and characterization of chromosomal rearrangements in AML. Case reports like this, as well as population-based studies, are necessary for understanding the karyotypic changes that occur in humans. |
publisher |
Associação Paulista de Medicina - APM |
publishDate |
2018 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802018000400361 |
work_keys_str_mv |
AT ornellasmariahelenafaria complexkaryotypeincludingringchromosome11inapatientwithacutemyeloidleukemiacasereport AT maiolimariachristinapaixao complexkaryotypeincludingringchromosome11inapatientwithacutemyeloidleukemiacasereport AT lucenastellabeatrizsampaiogoncalvesde complexkaryotypeincludingringchromosome11inapatientwithacutemyeloidleukemiacasereport AT bastoseleniceferreira complexkaryotypeincludingringchromosome11inapatientwithacutemyeloidleukemiacasereport AT chavestatianasilva complexkaryotypeincludingringchromosome11inapatientwithacutemyeloidleukemiacasereport AT melokarinavieirade complexkaryotypeincludingringchromosome11inapatientwithacutemyeloidleukemiacasereport AT ribeirocarvalhomarilzademoura complexkaryotypeincludingringchromosome11inapatientwithacutemyeloidleukemiacasereport AT liehrthomas complexkaryotypeincludingringchromosome11inapatientwithacutemyeloidleukemiacasereport AT alvesgilda complexkaryotypeincludingringchromosome11inapatientwithacutemyeloidleukemiacasereport |
_version_ |
1756421673255436288 |