Pulmonary emphysema induced by methylphenidate: experimental study
CONTEXT AND OBJECTIVE: Methylphenidate is the most widely used drug for treating attention deficit hyperactivity disorder. However, it has important side effects, such as abdominal pain, insomnia, anorexia and loss of appetite, and also some cases of early severe emphysema after drug abuse have been reported. Our aim was to investigate the development of pulmonary emphysema in rats that were subjected to different doses of methylphenidate.DESIGN AND SETTING: Experimental study carried out at the laboratory of a public university.METHODS: Eighteen male Wistar rats were divided into three groups: control (0.9% saline solution); MP 0.8 (methylphenidate, 0.8 mg/kg); MP 1.2 (methylphenidate, 1.2 mg/kg). After 90 days of daily gavage, the animals were sacrificed and lung tissue samples were prepared for analysis on the mean alveolar diameter (Lm).RESULTS: The Lm was greater in MP 0.8 (47.91 ± 3.13; P < 0.01) and MP 1.2 (46.36 ± 4.39; P < 0.05) than in the control group (40.00 ± 3.48).CONCLUSION: Methylphenidate caused an increase in the alveolar diameter of rats, which was compatible with human pulmonary emphysema.
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Associação Paulista de Medicina - APM
2015
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oai:scielo:S1516-318020150002001312015-10-09Pulmonary emphysema induced by methylphenidate: experimental studyRapello,Gabriel Victor GuimarãesAntoniolli,AndréiaPereira,Daniel MartinsFacco,GilbertoPêgo-Fernandes,Paulo ManuelPazetti,Rogério Methylphenidate Attention deficit disorder with hyperactivity Pulmonary emphysema Rats Lung CONTEXT AND OBJECTIVE: Methylphenidate is the most widely used drug for treating attention deficit hyperactivity disorder. However, it has important side effects, such as abdominal pain, insomnia, anorexia and loss of appetite, and also some cases of early severe emphysema after drug abuse have been reported. Our aim was to investigate the development of pulmonary emphysema in rats that were subjected to different doses of methylphenidate.DESIGN AND SETTING: Experimental study carried out at the laboratory of a public university.METHODS: Eighteen male Wistar rats were divided into three groups: control (0.9% saline solution); MP 0.8 (methylphenidate, 0.8 mg/kg); MP 1.2 (methylphenidate, 1.2 mg/kg). After 90 days of daily gavage, the animals were sacrificed and lung tissue samples were prepared for analysis on the mean alveolar diameter (Lm).RESULTS: The Lm was greater in MP 0.8 (47.91 ± 3.13; P < 0.01) and MP 1.2 (46.36 ± 4.39; P < 0.05) than in the control group (40.00 ± 3.48).CONCLUSION: Methylphenidate caused an increase in the alveolar diameter of rats, which was compatible with human pulmonary emphysema.info:eu-repo/semantics/openAccessAssociação Paulista de Medicina - APMSao Paulo Medical Journal v.133 n.2 20152015-04-01info:eu-repo/semantics/othertext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802015000200131en10.1590/1516-3180.2014.8470910 |
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Rapello,Gabriel Victor Guimarães Antoniolli,Andréia Pereira,Daniel Martins Facco,Gilberto Pêgo-Fernandes,Paulo Manuel Pazetti,Rogério |
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Rapello,Gabriel Victor Guimarães Antoniolli,Andréia Pereira,Daniel Martins Facco,Gilberto Pêgo-Fernandes,Paulo Manuel Pazetti,Rogério Pulmonary emphysema induced by methylphenidate: experimental study |
author_facet |
Rapello,Gabriel Victor Guimarães Antoniolli,Andréia Pereira,Daniel Martins Facco,Gilberto Pêgo-Fernandes,Paulo Manuel Pazetti,Rogério |
author_sort |
Rapello,Gabriel Victor Guimarães |
title |
Pulmonary emphysema induced by methylphenidate: experimental study |
title_short |
Pulmonary emphysema induced by methylphenidate: experimental study |
title_full |
Pulmonary emphysema induced by methylphenidate: experimental study |
title_fullStr |
Pulmonary emphysema induced by methylphenidate: experimental study |
title_full_unstemmed |
Pulmonary emphysema induced by methylphenidate: experimental study |
title_sort |
pulmonary emphysema induced by methylphenidate: experimental study |
description |
CONTEXT AND OBJECTIVE: Methylphenidate is the most widely used drug for treating attention deficit hyperactivity disorder. However, it has important side effects, such as abdominal pain, insomnia, anorexia and loss of appetite, and also some cases of early severe emphysema after drug abuse have been reported. Our aim was to investigate the development of pulmonary emphysema in rats that were subjected to different doses of methylphenidate.DESIGN AND SETTING: Experimental study carried out at the laboratory of a public university.METHODS: Eighteen male Wistar rats were divided into three groups: control (0.9% saline solution); MP 0.8 (methylphenidate, 0.8 mg/kg); MP 1.2 (methylphenidate, 1.2 mg/kg). After 90 days of daily gavage, the animals were sacrificed and lung tissue samples were prepared for analysis on the mean alveolar diameter (Lm).RESULTS: The Lm was greater in MP 0.8 (47.91 ± 3.13; P < 0.01) and MP 1.2 (46.36 ± 4.39; P < 0.05) than in the control group (40.00 ± 3.48).CONCLUSION: Methylphenidate caused an increase in the alveolar diameter of rats, which was compatible with human pulmonary emphysema. |
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Associação Paulista de Medicina - APM |
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2015 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802015000200131 |
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