Indolent systemic mastocytosis limited to the bone: a case report and review of the literature
CONTEXT Systemic mastocytosis is defined as a clonal disorder of mast cells and their precursor cells and is currently classified as a myeloproliferative neoplasm. Its clinical course has a wide spectrum, ranging from indolent disease, with normal life expectancy, to highly aggressive disease, associated with multisystemic involvement and poor overall survival. The aim of this study was to report a case of indolent systemic mastocytosis, focusing on the diagnostic challenges, with a review of the literature. CASE REPORT A 79-year-old Caucasian woman with osteoporosis was evaluated at the Emergency Department because of complaints of low back pain. Before this, she had consulted an orthopedist and had undergone some imaging examinations, namely a bone scan that revealed a “superscan” pattern. Due to her pain complaints and these test results, the patient was admitted to the Department of Internal Medicine. After undergoing several analytical tests and some additional imaging examinations to rule out some important differential diagnoses, she then underwent bone marrow biopsy, which made it possible to identify indolent systemic mastocytosis. CONCLUSION Systemic mastocytosis is a rare entity that is difficult to diagnose. Its symptoms are often unspecific and frequently ignored. Skeletal changes may be the first and only manifestation of the disease and in some cases, like this one, the diagnosis is made only after histological examination. The key point for the diagnosis is to contemplate the possibility of systemic mastocytosis.
Main Authors: | , , , , |
---|---|
Format: | Digital revista |
Language: | English |
Published: |
Associação Paulista de Medicina - APM
2013
|
Online Access: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802013000300198 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
oai:scielo:S1516-31802013000300198 |
---|---|
record_format |
ojs |
spelling |
oai:scielo:S1516-318020130003001982013-10-08Indolent systemic mastocytosis limited to the bone: a case report and review of the literaturePinto-Lopes,PedroFonseca,Francisco AdaoSilva,RobertoHafe,Pedro vonFonseca,Elsa Mastocytosis Myeloproliferative disorders Musculoskeletal diseases Osteoporosis Low back pain CONTEXT Systemic mastocytosis is defined as a clonal disorder of mast cells and their precursor cells and is currently classified as a myeloproliferative neoplasm. Its clinical course has a wide spectrum, ranging from indolent disease, with normal life expectancy, to highly aggressive disease, associated with multisystemic involvement and poor overall survival. The aim of this study was to report a case of indolent systemic mastocytosis, focusing on the diagnostic challenges, with a review of the literature. CASE REPORT A 79-year-old Caucasian woman with osteoporosis was evaluated at the Emergency Department because of complaints of low back pain. Before this, she had consulted an orthopedist and had undergone some imaging examinations, namely a bone scan that revealed a “superscan” pattern. Due to her pain complaints and these test results, the patient was admitted to the Department of Internal Medicine. After undergoing several analytical tests and some additional imaging examinations to rule out some important differential diagnoses, she then underwent bone marrow biopsy, which made it possible to identify indolent systemic mastocytosis. CONCLUSION Systemic mastocytosis is a rare entity that is difficult to diagnose. Its symptoms are often unspecific and frequently ignored. Skeletal changes may be the first and only manifestation of the disease and in some cases, like this one, the diagnosis is made only after histological examination. The key point for the diagnosis is to contemplate the possibility of systemic mastocytosis. info:eu-repo/semantics/openAccessAssociação Paulista de Medicina - APMSao Paulo Medical Journal v.131 n.3 20132013-01-01info:eu-repo/semantics/reporttext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802013000300198en10.1590/1516-3180.2013.1313460 |
institution |
SCIELO |
collection |
OJS |
country |
Brasil |
countrycode |
BR |
component |
Revista |
access |
En linea |
databasecode |
rev-scielo-br |
tag |
revista |
region |
America del Sur |
libraryname |
SciELO |
language |
English |
format |
Digital |
author |
Pinto-Lopes,Pedro Fonseca,Francisco Adao Silva,Roberto Hafe,Pedro von Fonseca,Elsa |
spellingShingle |
Pinto-Lopes,Pedro Fonseca,Francisco Adao Silva,Roberto Hafe,Pedro von Fonseca,Elsa Indolent systemic mastocytosis limited to the bone: a case report and review of the literature |
author_facet |
Pinto-Lopes,Pedro Fonseca,Francisco Adao Silva,Roberto Hafe,Pedro von Fonseca,Elsa |
author_sort |
Pinto-Lopes,Pedro |
title |
Indolent systemic mastocytosis limited to the bone: a case report and review of the literature |
title_short |
Indolent systemic mastocytosis limited to the bone: a case report and review of the literature |
title_full |
Indolent systemic mastocytosis limited to the bone: a case report and review of the literature |
title_fullStr |
Indolent systemic mastocytosis limited to the bone: a case report and review of the literature |
title_full_unstemmed |
Indolent systemic mastocytosis limited to the bone: a case report and review of the literature |
title_sort |
indolent systemic mastocytosis limited to the bone: a case report and review of the literature |
description |
CONTEXT Systemic mastocytosis is defined as a clonal disorder of mast cells and their precursor cells and is currently classified as a myeloproliferative neoplasm. Its clinical course has a wide spectrum, ranging from indolent disease, with normal life expectancy, to highly aggressive disease, associated with multisystemic involvement and poor overall survival. The aim of this study was to report a case of indolent systemic mastocytosis, focusing on the diagnostic challenges, with a review of the literature. CASE REPORT A 79-year-old Caucasian woman with osteoporosis was evaluated at the Emergency Department because of complaints of low back pain. Before this, she had consulted an orthopedist and had undergone some imaging examinations, namely a bone scan that revealed a “superscan” pattern. Due to her pain complaints and these test results, the patient was admitted to the Department of Internal Medicine. After undergoing several analytical tests and some additional imaging examinations to rule out some important differential diagnoses, she then underwent bone marrow biopsy, which made it possible to identify indolent systemic mastocytosis. CONCLUSION Systemic mastocytosis is a rare entity that is difficult to diagnose. Its symptoms are often unspecific and frequently ignored. Skeletal changes may be the first and only manifestation of the disease and in some cases, like this one, the diagnosis is made only after histological examination. The key point for the diagnosis is to contemplate the possibility of systemic mastocytosis. |
publisher |
Associação Paulista de Medicina - APM |
publishDate |
2013 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802013000300198 |
work_keys_str_mv |
AT pintolopespedro indolentsystemicmastocytosislimitedtotheboneacasereportandreviewoftheliterature AT fonsecafranciscoadao indolentsystemicmastocytosislimitedtotheboneacasereportandreviewoftheliterature AT silvaroberto indolentsystemicmastocytosislimitedtotheboneacasereportandreviewoftheliterature AT hafepedrovon indolentsystemicmastocytosislimitedtotheboneacasereportandreviewoftheliterature AT fonsecaelsa indolentsystemicmastocytosislimitedtotheboneacasereportandreviewoftheliterature |
_version_ |
1756421586395594752 |