Fluorine-Containing Bioactive Glass Spherical Particles Synthesized By Sol-Gel Route Assisted by Ultrasound Energy or Mechanical Mixing
Bioactive glasses (BG) are versatile materials for various biomedical applications due to their capacity to bond to hard and soft tissues. These materials can be produced with different nominal compositions, such that include fluoride ions. Fluorine-containing-BG (BGF) can be produced by the sol-gel method, and its properties can be changed by altering the synthesis parameters. Here, BGF particle size between 235 nm-390 nm were obtained through sol-gel method assisted by ultrasound energy (BGU) or through mechanical stirring (BGM). The BGM and BGU particles showed highly dispersed spherical shape, moreover BGM are mesoporous and BGU are dense structures, indicating mixing mode can alter mainly the material textural characteristics. All compositions have apatite forming ability, verified by DRX from 14 days in SBF. The results showed CaF2 on the surface of BGF particles, indicating that part of F ions was not incorporated in the material network. The samples did not show any cytotoxicity towards human cells in Cellular Metabolic Activity and Calcein assays. This study showed that mechanical agitation was more efficient to produce mesoporous particles to be applied as carrier of drugs and molecules to the biological environment, so BGM can be used as a more efficient biomaterial for such applications.
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ABM, ABC, ABPol
2020
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oai:scielo:S1516-143920200003002112020-07-10Fluorine-Containing Bioactive Glass Spherical Particles Synthesized By Sol-Gel Route Assisted by Ultrasound Energy or Mechanical MixingSouza,Ingrid Elen Pinto eCarvalho,Sandhra Maria deMartins,TalitaPereira,Marivalda de Magalhães Bioactive glass Fluorine mechanical stirring ultrasound energy sol gel Bioactive glasses (BG) are versatile materials for various biomedical applications due to their capacity to bond to hard and soft tissues. These materials can be produced with different nominal compositions, such that include fluoride ions. Fluorine-containing-BG (BGF) can be produced by the sol-gel method, and its properties can be changed by altering the synthesis parameters. Here, BGF particle size between 235 nm-390 nm were obtained through sol-gel method assisted by ultrasound energy (BGU) or through mechanical stirring (BGM). The BGM and BGU particles showed highly dispersed spherical shape, moreover BGM are mesoporous and BGU are dense structures, indicating mixing mode can alter mainly the material textural characteristics. All compositions have apatite forming ability, verified by DRX from 14 days in SBF. The results showed CaF2 on the surface of BGF particles, indicating that part of F ions was not incorporated in the material network. The samples did not show any cytotoxicity towards human cells in Cellular Metabolic Activity and Calcein assays. This study showed that mechanical agitation was more efficient to produce mesoporous particles to be applied as carrier of drugs and molecules to the biological environment, so BGM can be used as a more efficient biomaterial for such applications.info:eu-repo/semantics/openAccessABM, ABC, ABPolMaterials Research v.23 n.3 20202020-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392020000300211en10.1590/1980-5373-mr-2020-0070 |
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Souza,Ingrid Elen Pinto e Carvalho,Sandhra Maria de Martins,Talita Pereira,Marivalda de Magalhães |
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Souza,Ingrid Elen Pinto e Carvalho,Sandhra Maria de Martins,Talita Pereira,Marivalda de Magalhães Fluorine-Containing Bioactive Glass Spherical Particles Synthesized By Sol-Gel Route Assisted by Ultrasound Energy or Mechanical Mixing |
| author_facet |
Souza,Ingrid Elen Pinto e Carvalho,Sandhra Maria de Martins,Talita Pereira,Marivalda de Magalhães |
| author_sort |
Souza,Ingrid Elen Pinto e |
| title |
Fluorine-Containing Bioactive Glass Spherical Particles Synthesized By Sol-Gel Route Assisted by Ultrasound Energy or Mechanical Mixing |
| title_short |
Fluorine-Containing Bioactive Glass Spherical Particles Synthesized By Sol-Gel Route Assisted by Ultrasound Energy or Mechanical Mixing |
| title_full |
Fluorine-Containing Bioactive Glass Spherical Particles Synthesized By Sol-Gel Route Assisted by Ultrasound Energy or Mechanical Mixing |
| title_fullStr |
Fluorine-Containing Bioactive Glass Spherical Particles Synthesized By Sol-Gel Route Assisted by Ultrasound Energy or Mechanical Mixing |
| title_full_unstemmed |
Fluorine-Containing Bioactive Glass Spherical Particles Synthesized By Sol-Gel Route Assisted by Ultrasound Energy or Mechanical Mixing |
| title_sort |
fluorine-containing bioactive glass spherical particles synthesized by sol-gel route assisted by ultrasound energy or mechanical mixing |
| description |
Bioactive glasses (BG) are versatile materials for various biomedical applications due to their capacity to bond to hard and soft tissues. These materials can be produced with different nominal compositions, such that include fluoride ions. Fluorine-containing-BG (BGF) can be produced by the sol-gel method, and its properties can be changed by altering the synthesis parameters. Here, BGF particle size between 235 nm-390 nm were obtained through sol-gel method assisted by ultrasound energy (BGU) or through mechanical stirring (BGM). The BGM and BGU particles showed highly dispersed spherical shape, moreover BGM are mesoporous and BGU are dense structures, indicating mixing mode can alter mainly the material textural characteristics. All compositions have apatite forming ability, verified by DRX from 14 days in SBF. The results showed CaF2 on the surface of BGF particles, indicating that part of F ions was not incorporated in the material network. The samples did not show any cytotoxicity towards human cells in Cellular Metabolic Activity and Calcein assays. This study showed that mechanical agitation was more efficient to produce mesoporous particles to be applied as carrier of drugs and molecules to the biological environment, so BGM can be used as a more efficient biomaterial for such applications. |
| publisher |
ABM, ABC, ABPol |
| publishDate |
2020 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392020000300211 |
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