Menthol-loaded PLGA Micro and Nanospheres: Synthesis, Characterization and Degradation in Artificial Saliva
Menthol-loaded PLGA micro/nanospheres were synthesized using the multiple emulsion/solvent evaporation technique. Parameters such as stirring rate, external surfactant content, PLGA/menthol weight ratio, solvent evaporation and lyophilization time were evaluated as well as the degradation of micro/nanospheres in an artificial saliva medium. The menthol/PLGA micro/nanospheres thus obtained had a size distribution of between 217 nm and 13 µm and particles with spherical and dense morphology were evidenced by SEM micrographs. FTIR and TGA data showed an increase up to 60% of menthol incorporated in the micro/nanoparticles. The degradation of menthol-loaded PLGA micro/nanoparticles in artificial saliva significantly affected the particles morphology and appears to be an effective medium for releasing menthol.
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ABM, ABC, ABPol
2018
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oai:scielo:S1516-143920180002091022018-05-15Menthol-loaded PLGA Micro and Nanospheres: Synthesis, Characterization and Degradation in Artificial SalivaHolz,Juliana PelisoliBottene,Marcia KarpinskiJahno,Vanusca DalostoEinloft,SandraLigabue,Rosane emulsion menthol micro/nanospheres PLGA Menthol-loaded PLGA micro/nanospheres were synthesized using the multiple emulsion/solvent evaporation technique. Parameters such as stirring rate, external surfactant content, PLGA/menthol weight ratio, solvent evaporation and lyophilization time were evaluated as well as the degradation of micro/nanospheres in an artificial saliva medium. The menthol/PLGA micro/nanospheres thus obtained had a size distribution of between 217 nm and 13 µm and particles with spherical and dense morphology were evidenced by SEM micrographs. FTIR and TGA data showed an increase up to 60% of menthol incorporated in the micro/nanoparticles. The degradation of menthol-loaded PLGA micro/nanoparticles in artificial saliva significantly affected the particles morphology and appears to be an effective medium for releasing menthol.info:eu-repo/semantics/openAccessABM, ABC, ABPolMaterials Research v.21 n.2 20182018-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392018000209102en10.1590/1980-5373-mr-2017-0488 |
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Holz,Juliana Pelisoli Bottene,Marcia Karpinski Jahno,Vanusca Dalosto Einloft,Sandra Ligabue,Rosane |
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Holz,Juliana Pelisoli Bottene,Marcia Karpinski Jahno,Vanusca Dalosto Einloft,Sandra Ligabue,Rosane Menthol-loaded PLGA Micro and Nanospheres: Synthesis, Characterization and Degradation in Artificial Saliva |
| author_facet |
Holz,Juliana Pelisoli Bottene,Marcia Karpinski Jahno,Vanusca Dalosto Einloft,Sandra Ligabue,Rosane |
| author_sort |
Holz,Juliana Pelisoli |
| title |
Menthol-loaded PLGA Micro and Nanospheres: Synthesis, Characterization and Degradation in Artificial Saliva |
| title_short |
Menthol-loaded PLGA Micro and Nanospheres: Synthesis, Characterization and Degradation in Artificial Saliva |
| title_full |
Menthol-loaded PLGA Micro and Nanospheres: Synthesis, Characterization and Degradation in Artificial Saliva |
| title_fullStr |
Menthol-loaded PLGA Micro and Nanospheres: Synthesis, Characterization and Degradation in Artificial Saliva |
| title_full_unstemmed |
Menthol-loaded PLGA Micro and Nanospheres: Synthesis, Characterization and Degradation in Artificial Saliva |
| title_sort |
menthol-loaded plga micro and nanospheres: synthesis, characterization and degradation in artificial saliva |
| description |
Menthol-loaded PLGA micro/nanospheres were synthesized using the multiple emulsion/solvent evaporation technique. Parameters such as stirring rate, external surfactant content, PLGA/menthol weight ratio, solvent evaporation and lyophilization time were evaluated as well as the degradation of micro/nanospheres in an artificial saliva medium. The menthol/PLGA micro/nanospheres thus obtained had a size distribution of between 217 nm and 13 µm and particles with spherical and dense morphology were evidenced by SEM micrographs. FTIR and TGA data showed an increase up to 60% of menthol incorporated in the micro/nanoparticles. The degradation of menthol-loaded PLGA micro/nanoparticles in artificial saliva significantly affected the particles morphology and appears to be an effective medium for releasing menthol. |
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ABM, ABC, ABPol |
| publishDate |
2018 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392018000209102 |
| work_keys_str_mv |
AT holzjulianapelisoli mentholloadedplgamicroandnanospheressynthesischaracterizationanddegradationinartificialsaliva AT bottenemarciakarpinski mentholloadedplgamicroandnanospheressynthesischaracterizationanddegradationinartificialsaliva AT jahnovanuscadalosto mentholloadedplgamicroandnanospheressynthesischaracterizationanddegradationinartificialsaliva AT einloftsandra mentholloadedplgamicroandnanospheressynthesischaracterizationanddegradationinartificialsaliva AT ligabuerosane mentholloadedplgamicroandnanospheressynthesischaracterizationanddegradationinartificialsaliva |
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1756420817310187520 |