Rabies virus diversification in aerial and terrestrial mammals
Abstract Rabies is a fatal zoonotic infection of the central nervous system of mammals and has been known to humans for millennia. The etiological agent, is a neurotropic RNA virus in the order Mononegavirales, family Rhabdoviridae, genus Lyssavirus. There are currently accepted to be two cycles for rabies transmission: the urban cycle and the sylvatic cycle. The fact that both cycles originated from a common RABV or lyssavirus ancestor and the adaptive divergence that occurred since then as this ancestor virus adapted to a wide range of fitness landscapes represented by reservoir species in the orders Carnivora and Chiroptera led to the emergence of the diverse RABV lineages currently found in the sylvatic and urban cycles. Here we study full genome phylogenies and the time to the most recent common ancestor (TMRCA) of the RABVs in the sylvatic and urban cycles. Results show that there were differences between the nucleotide substitution rates per site per year for the same RABV genes maintained independently in the urban and sylvatic cycles. The results identify the most suitable gene for phylogenetic analysis, heterotachy among RABV genes and the TMRCA for the two cycles.
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Sociedade Brasileira de Genética
2020
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oai:scielo:S1415-475720200005006012020-07-29Rabies virus diversification in aerial and terrestrial mammalsOliveira,Rafael N.Freire,Caio C.Iamarino,AtilaZanotto,Paolo M.Pessoa,RodrigoSanabani,Sabri S.Souza,Sibele Pinheiro deCastilho,Juliana G.Batista,Helena B. C. R.Carnieli Jr.,PedroMacedo,Carla I.Watanabe,Jaqueline T.Brandão,Paulo E. Rabies virus genome molecular evolution phylogeny heterotachy Abstract Rabies is a fatal zoonotic infection of the central nervous system of mammals and has been known to humans for millennia. The etiological agent, is a neurotropic RNA virus in the order Mononegavirales, family Rhabdoviridae, genus Lyssavirus. There are currently accepted to be two cycles for rabies transmission: the urban cycle and the sylvatic cycle. The fact that both cycles originated from a common RABV or lyssavirus ancestor and the adaptive divergence that occurred since then as this ancestor virus adapted to a wide range of fitness landscapes represented by reservoir species in the orders Carnivora and Chiroptera led to the emergence of the diverse RABV lineages currently found in the sylvatic and urban cycles. Here we study full genome phylogenies and the time to the most recent common ancestor (TMRCA) of the RABVs in the sylvatic and urban cycles. Results show that there were differences between the nucleotide substitution rates per site per year for the same RABV genes maintained independently in the urban and sylvatic cycles. The results identify the most suitable gene for phylogenetic analysis, heterotachy among RABV genes and the TMRCA for the two cycles.info:eu-repo/semantics/openAccessSociedade Brasileira de GenéticaGenetics and Molecular Biology v.43 n.3 20202020-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000500601en10.1590/1678-4685-gmb-2019-0370 |
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Oliveira,Rafael N. Freire,Caio C. Iamarino,Atila Zanotto,Paolo M. Pessoa,Rodrigo Sanabani,Sabri S. Souza,Sibele Pinheiro de Castilho,Juliana G. Batista,Helena B. C. R. Carnieli Jr.,Pedro Macedo,Carla I. Watanabe,Jaqueline T. Brandão,Paulo E. |
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Oliveira,Rafael N. Freire,Caio C. Iamarino,Atila Zanotto,Paolo M. Pessoa,Rodrigo Sanabani,Sabri S. Souza,Sibele Pinheiro de Castilho,Juliana G. Batista,Helena B. C. R. Carnieli Jr.,Pedro Macedo,Carla I. Watanabe,Jaqueline T. Brandão,Paulo E. Rabies virus diversification in aerial and terrestrial mammals |
author_facet |
Oliveira,Rafael N. Freire,Caio C. Iamarino,Atila Zanotto,Paolo M. Pessoa,Rodrigo Sanabani,Sabri S. Souza,Sibele Pinheiro de Castilho,Juliana G. Batista,Helena B. C. R. Carnieli Jr.,Pedro Macedo,Carla I. Watanabe,Jaqueline T. Brandão,Paulo E. |
author_sort |
Oliveira,Rafael N. |
title |
Rabies virus diversification in aerial and terrestrial mammals |
title_short |
Rabies virus diversification in aerial and terrestrial mammals |
title_full |
Rabies virus diversification in aerial and terrestrial mammals |
title_fullStr |
Rabies virus diversification in aerial and terrestrial mammals |
title_full_unstemmed |
Rabies virus diversification in aerial and terrestrial mammals |
title_sort |
rabies virus diversification in aerial and terrestrial mammals |
description |
Abstract Rabies is a fatal zoonotic infection of the central nervous system of mammals and has been known to humans for millennia. The etiological agent, is a neurotropic RNA virus in the order Mononegavirales, family Rhabdoviridae, genus Lyssavirus. There are currently accepted to be two cycles for rabies transmission: the urban cycle and the sylvatic cycle. The fact that both cycles originated from a common RABV or lyssavirus ancestor and the adaptive divergence that occurred since then as this ancestor virus adapted to a wide range of fitness landscapes represented by reservoir species in the orders Carnivora and Chiroptera led to the emergence of the diverse RABV lineages currently found in the sylvatic and urban cycles. Here we study full genome phylogenies and the time to the most recent common ancestor (TMRCA) of the RABVs in the sylvatic and urban cycles. Results show that there were differences between the nucleotide substitution rates per site per year for the same RABV genes maintained independently in the urban and sylvatic cycles. The results identify the most suitable gene for phylogenetic analysis, heterotachy among RABV genes and the TMRCA for the two cycles. |
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Sociedade Brasileira de Genética |
publishDate |
2020 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572020000500601 |
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