Histone deacetylase inhibitors as potential treatment for spinal muscular atrophy

Histone deacetylase inhibitors as potential treatment for spinal muscular atrophy

Histone acetylation plays an important role in regulation of transcription in eukaryotic cells by promoting a more relaxed chromatin structure necessary for transcriptional activation. Histone deacetylases (HDACs) remove acetyl groups and suppress gene expression. HDAC inhibitors (HDACIs) are a group of small molecules that promote gene transcription by chromatin remodeling and have been extensively studied as potential drugs for treating of spinal muscular atrophy. Various drugs in this class have been studied with regard to their efficacy in increasing the expression of survival of motor neuron (SMN) protein. In this review, we discuss the current literature on this topic and summarize the findings of the main studies in this field.

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Main Authors: Mohseni,Jafar, Zabidi-Hussin,Z.A.M.H., Sasongko,Teguh Haryo
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Genética 2013
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572013000300001
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spelling oai:scielo:S1415-475720130003000012013-08-23Histone deacetylase inhibitors as potential treatment for spinal muscular atrophyMohseni,JafarZabidi-Hussin,Z.A.M.H.Sasongko,Teguh Haryo HDACi molecular therapy spinal muscular atrophy Histone acetylation plays an important role in regulation of transcription in eukaryotic cells by promoting a more relaxed chromatin structure necessary for transcriptional activation. Histone deacetylases (HDACs) remove acetyl groups and suppress gene expression. HDAC inhibitors (HDACIs) are a group of small molecules that promote gene transcription by chromatin remodeling and have been extensively studied as potential drugs for treating of spinal muscular atrophy. Various drugs in this class have been studied with regard to their efficacy in increasing the expression of survival of motor neuron (SMN) protein. In this review, we discuss the current literature on this topic and summarize the findings of the main studies in this field.info:eu-repo/semantics/openAccessSociedade Brasileira de GenéticaGenetics and Molecular Biology v.36 n.3 20132013-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572013000300001en10.1590/S1415-47572013000300001
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country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
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region America del Sur
libraryname SciELO
language English
format Digital
author Mohseni,Jafar
Zabidi-Hussin,Z.A.M.H.
Sasongko,Teguh Haryo
spellingShingle Mohseni,Jafar
Zabidi-Hussin,Z.A.M.H.
Sasongko,Teguh Haryo
Histone deacetylase inhibitors as potential treatment for spinal muscular atrophy
author_facet Mohseni,Jafar
Zabidi-Hussin,Z.A.M.H.
Sasongko,Teguh Haryo
author_sort Mohseni,Jafar
title Histone deacetylase inhibitors as potential treatment for spinal muscular atrophy
title_short Histone deacetylase inhibitors as potential treatment for spinal muscular atrophy
title_full Histone deacetylase inhibitors as potential treatment for spinal muscular atrophy
title_fullStr Histone deacetylase inhibitors as potential treatment for spinal muscular atrophy
title_full_unstemmed Histone deacetylase inhibitors as potential treatment for spinal muscular atrophy
title_sort histone deacetylase inhibitors as potential treatment for spinal muscular atrophy
description Histone acetylation plays an important role in regulation of transcription in eukaryotic cells by promoting a more relaxed chromatin structure necessary for transcriptional activation. Histone deacetylases (HDACs) remove acetyl groups and suppress gene expression. HDAC inhibitors (HDACIs) are a group of small molecules that promote gene transcription by chromatin remodeling and have been extensively studied as potential drugs for treating of spinal muscular atrophy. Various drugs in this class have been studied with regard to their efficacy in increasing the expression of survival of motor neuron (SMN) protein. In this review, we discuss the current literature on this topic and summarize the findings of the main studies in this field.
publisher Sociedade Brasileira de Genética
publishDate 2013
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572013000300001
work_keys_str_mv AT mohsenijafar histonedeacetylaseinhibitorsaspotentialtreatmentforspinalmuscularatrophy
AT zabidihussinzamh histonedeacetylaseinhibitorsaspotentialtreatmentforspinalmuscularatrophy
AT sasongkoteguhharyo histonedeacetylaseinhibitorsaspotentialtreatmentforspinalmuscularatrophy
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