Characterization of PRLR and PPARGC1A genes in buffalo (Bubalus bubalis)

Characterization of PRLR and PPARGC1A genes in buffalo (Bubalus bubalis)

More than 40 million households in India depend at least partially on livestock production. Buffaloes are one of the major milk producers in India. The prolactin receptor (PRLR) gene and peroxisome proliferators activated receptor-γ coactivator 1-alpha (PPARGC1A) gene are reportedly associated with milk protein and milk fat yields in Bos taurus. In this study, we sequenced the PRLR and PPARGC1A genes in the water buffalo Bubalus bubalis. The PRLR and PPARGC1A genes coded for 581 and 819 amino acids, respectively. The B. bubalis PRLR gene differed from the corresponding Bos taurus at 21 positions and four differences with an additional arginine at position 620 in the PPARGC1A gene were found in the amino acid sequence. All of the changes were confirmed by cDNA sequencing. Twelve buffalo-specific single nucleotide polymorphisms (SNPs) were identified in both genes, with five of them being non-synonymous.

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Main Authors: Javed,Ruheena, Gautam,Sanjeev K., Vijh,Ramesh K., Tantia,Madhu S.
Format: Digital revista
Language:English
Published: Sociedade Brasileira de Genética 2011
Online Access:http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000400011
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spelling oai:scielo:S1415-475720110004000112011-11-11Characterization of PRLR and PPARGC1A genes in buffalo (Bubalus bubalis)Javed,RuheenaGautam,Sanjeev K.Vijh,Ramesh K.Tantia,Madhu S. Bubalus bubalis buffalo PRLR gene PPARGC1A gene More than 40 million households in India depend at least partially on livestock production. Buffaloes are one of the major milk producers in India. The prolactin receptor (PRLR) gene and peroxisome proliferators activated receptor-γ coactivator 1-alpha (PPARGC1A) gene are reportedly associated with milk protein and milk fat yields in Bos taurus. In this study, we sequenced the PRLR and PPARGC1A genes in the water buffalo Bubalus bubalis. The PRLR and PPARGC1A genes coded for 581 and 819 amino acids, respectively. The B. bubalis PRLR gene differed from the corresponding Bos taurus at 21 positions and four differences with an additional arginine at position 620 in the PPARGC1A gene were found in the amino acid sequence. All of the changes were confirmed by cDNA sequencing. Twelve buffalo-specific single nucleotide polymorphisms (SNPs) were identified in both genes, with five of them being non-synonymous.info:eu-repo/semantics/openAccessSociedade Brasileira de GenéticaGenetics and Molecular Biology v.34 n.4 20112011-01-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000400011en10.1590/S1415-47572011005000037
institution SCIELO
collection OJS
country Brasil
countrycode BR
component Revista
access En linea
databasecode rev-scielo-br
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author Javed,Ruheena
Gautam,Sanjeev K.
Vijh,Ramesh K.
Tantia,Madhu S.
spellingShingle Javed,Ruheena
Gautam,Sanjeev K.
Vijh,Ramesh K.
Tantia,Madhu S.
Characterization of PRLR and PPARGC1A genes in buffalo (Bubalus bubalis)
author_facet Javed,Ruheena
Gautam,Sanjeev K.
Vijh,Ramesh K.
Tantia,Madhu S.
author_sort Javed,Ruheena
title Characterization of PRLR and PPARGC1A genes in buffalo (Bubalus bubalis)
title_short Characterization of PRLR and PPARGC1A genes in buffalo (Bubalus bubalis)
title_full Characterization of PRLR and PPARGC1A genes in buffalo (Bubalus bubalis)
title_fullStr Characterization of PRLR and PPARGC1A genes in buffalo (Bubalus bubalis)
title_full_unstemmed Characterization of PRLR and PPARGC1A genes in buffalo (Bubalus bubalis)
title_sort characterization of prlr and ppargc1a genes in buffalo (bubalus bubalis)
description More than 40 million households in India depend at least partially on livestock production. Buffaloes are one of the major milk producers in India. The prolactin receptor (PRLR) gene and peroxisome proliferators activated receptor-γ coactivator 1-alpha (PPARGC1A) gene are reportedly associated with milk protein and milk fat yields in Bos taurus. In this study, we sequenced the PRLR and PPARGC1A genes in the water buffalo Bubalus bubalis. The PRLR and PPARGC1A genes coded for 581 and 819 amino acids, respectively. The B. bubalis PRLR gene differed from the corresponding Bos taurus at 21 positions and four differences with an additional arginine at position 620 in the PPARGC1A gene were found in the amino acid sequence. All of the changes were confirmed by cDNA sequencing. Twelve buffalo-specific single nucleotide polymorphisms (SNPs) were identified in both genes, with five of them being non-synonymous.
publisher Sociedade Brasileira de Genética
publishDate 2011
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572011000400011
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