Evaluation of the genotoxic potential of the Hypericum brasiliense (Guttiferae) extract in mammalian cell system in vivo

Plants of the genus Hypericum, long used in folk medicine, contain active compounds which present, anti-septic, diuretic, digestive, expectorant, vermifugal, anti-depressive and other properties. The possible clastogenic effect of a H. brasiliense extract was tested in vivo on the bone marrow cells of Wistar rats. The extract was administered by gavage at doses of 50, 150 and 300 mg/kg body weight. Experimental and control animals were submitted to euthanasia 24 h after the treatment for micronucleus (MN) and chromosome preparations. H. brasiliense extract did not induce statistically significant increases in the average numbers of MN or chromosome aberrations in the test systems employed.

Bibliographic Details

Main Authors:	Espósito,Anderson Victorino, Pereira,Danielli Maria Vieira, Rocha,Leandro Machado, Carvalho,José Carlos Tavares, Maistro,Edson Luis
Format:	Digital revista
Language:	English
Published:	Sociedade Brasileira de Genética 2005
Online Access:	http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572005000100026
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