Fluconazole prophylaxis in preterm infants: a systematic review
ABSTRACT Objective: This article aims to review the use of antifungal prophylaxis with intravenous fluconazole in premature newborns and the occurrence of Invasive Candidiasis. Methods: This is a systematic review with search at databases: PubMed, Capes Portal, Virtual Health Library (BVS - Biblioteca Virtual em Saúde)/Lilacs, Scopus and Cochrane. The keywords used were: "Antifungal", "Candida" "Fluconazole prophylaxis" and "Preterm infants". Results: Invasive Candidiasis was evaluated in all the twelve items. In eleven of them, there was a statistically significant difference between the groups receiving prophylactic fluconazole, with lower frequency of Invasive Candidiasis, compared to placebo or no prophylaxis group. Colonization by Candida species was also evaluated in five studies; four of them presented statistically lower proportion of colonization in patients with Fluconazole prophylaxis, compared to placebo or no drugs. In one study, there was a significant difference, favoring the use of fluconazole, and reduction of death. Conclusion: Studies indicate the effectiveness of prophylaxis with fluconazole, with reduction in the incidence of colonization and invasive fungal disease. The benefits of prophylaxis should be evaluated considering the incidence of candidiasis in the unit, the mortality associated with candidiasis, the safety and toxicity of short and long-term medication, and the potential for development of resistant pathogens.
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Brazilian Society of Infectious Diseases
2017
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oai:scielo:S1413-867020170003003332017-06-19Fluconazole prophylaxis in preterm infants: a systematic reviewRios,Juliana Ferreira da SilvaCamargos,Paulo Augusto MoreiraCorrêa,Luísa PetriRomanelli,Roberta Maia de Castro Antifungal Candida Fluconazole prophylaxis Preterm infants ABSTRACT Objective: This article aims to review the use of antifungal prophylaxis with intravenous fluconazole in premature newborns and the occurrence of Invasive Candidiasis. Methods: This is a systematic review with search at databases: PubMed, Capes Portal, Virtual Health Library (BVS - Biblioteca Virtual em Saúde)/Lilacs, Scopus and Cochrane. The keywords used were: "Antifungal", "Candida" "Fluconazole prophylaxis" and "Preterm infants". Results: Invasive Candidiasis was evaluated in all the twelve items. In eleven of them, there was a statistically significant difference between the groups receiving prophylactic fluconazole, with lower frequency of Invasive Candidiasis, compared to placebo or no prophylaxis group. Colonization by Candida species was also evaluated in five studies; four of them presented statistically lower proportion of colonization in patients with Fluconazole prophylaxis, compared to placebo or no drugs. In one study, there was a significant difference, favoring the use of fluconazole, and reduction of death. Conclusion: Studies indicate the effectiveness of prophylaxis with fluconazole, with reduction in the incidence of colonization and invasive fungal disease. The benefits of prophylaxis should be evaluated considering the incidence of candidiasis in the unit, the mortality associated with candidiasis, the safety and toxicity of short and long-term medication, and the potential for development of resistant pathogens.info:eu-repo/semantics/openAccessBrazilian Society of Infectious DiseasesBrazilian Journal of Infectious Diseases v.21 n.3 20172017-06-01info:eu-repo/semantics/articletext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000300333en10.1016/j.bjid.2017.01.008 |
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Rios,Juliana Ferreira da Silva Camargos,Paulo Augusto Moreira Corrêa,Luísa Petri Romanelli,Roberta Maia de Castro |
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Rios,Juliana Ferreira da Silva Camargos,Paulo Augusto Moreira Corrêa,Luísa Petri Romanelli,Roberta Maia de Castro Fluconazole prophylaxis in preterm infants: a systematic review |
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Rios,Juliana Ferreira da Silva Camargos,Paulo Augusto Moreira Corrêa,Luísa Petri Romanelli,Roberta Maia de Castro |
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Rios,Juliana Ferreira da Silva |
title |
Fluconazole prophylaxis in preterm infants: a systematic review |
title_short |
Fluconazole prophylaxis in preterm infants: a systematic review |
title_full |
Fluconazole prophylaxis in preterm infants: a systematic review |
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Fluconazole prophylaxis in preterm infants: a systematic review |
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Fluconazole prophylaxis in preterm infants: a systematic review |
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fluconazole prophylaxis in preterm infants: a systematic review |
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ABSTRACT Objective: This article aims to review the use of antifungal prophylaxis with intravenous fluconazole in premature newborns and the occurrence of Invasive Candidiasis. Methods: This is a systematic review with search at databases: PubMed, Capes Portal, Virtual Health Library (BVS - Biblioteca Virtual em Saúde)/Lilacs, Scopus and Cochrane. The keywords used were: "Antifungal", "Candida" "Fluconazole prophylaxis" and "Preterm infants". Results: Invasive Candidiasis was evaluated in all the twelve items. In eleven of them, there was a statistically significant difference between the groups receiving prophylactic fluconazole, with lower frequency of Invasive Candidiasis, compared to placebo or no prophylaxis group. Colonization by Candida species was also evaluated in five studies; four of them presented statistically lower proportion of colonization in patients with Fluconazole prophylaxis, compared to placebo or no drugs. In one study, there was a significant difference, favoring the use of fluconazole, and reduction of death. Conclusion: Studies indicate the effectiveness of prophylaxis with fluconazole, with reduction in the incidence of colonization and invasive fungal disease. The benefits of prophylaxis should be evaluated considering the incidence of candidiasis in the unit, the mortality associated with candidiasis, the safety and toxicity of short and long-term medication, and the potential for development of resistant pathogens. |
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Brazilian Society of Infectious Diseases |
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2017 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000300333 |
work_keys_str_mv |
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