Prolonged lymphocytosis as the first manifestation of Hodgkin-like adult T-cell leukemia/lymphoma
Abstract Hodgkin-like ATLL is a rare variant of adult T-cell leukemia/lymphoma (ATLL), a disease caused by human T-cell lymphotropic virus type-1 (HTLV-1). At admission, a 46-year-old female presented with lymphadenomegaly, lymphocytosis, slight elevation of LDH blood level, and acid-alcohol resistant bacilli in sputum and was being treated for pulmonary tuberculosis (Tb). She had lymphocytosis in the previous 20 months. Serology for HTLV-1 was positive. Lymph node was infiltrated by medium-sized lymphocytes with scattered Hodgkin and Reed-Sternberg-like cells CD30+, CS1-4+, and CD79a+. Background cells were CD4+ and CD25+. A clinical diagnosis of favorable chronic ATLL was given. She was treated with chemotherapy but later progressed to acute ATLL and ultimately died. Hodgkin-like ATLL should be considered in the histological differential diagnosis with Hodgkin lymphoma since treatment and prognosis of these diseases are distinct. It is also important to search for HTLV-1 infection in patients with unexplained prolonged lymphocytosis.
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Brazilian Society of Infectious Diseases
2017
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oai:scielo:S1413-867020170001001192017-03-06Prolonged lymphocytosis as the first manifestation of Hodgkin-like adult T-cell leukemia/lymphomaBittencourt,Achiléa L.Andrade,Agnes CarvalhoRequião,CristianeArruda,Maria da Gloria BomfimAraújo,Iguaracyra Adult T-cell leukemia/lymphoma HTLV-1 infection Pulmonary tuberculosis Hodgkin-like ATLL Abstract Hodgkin-like ATLL is a rare variant of adult T-cell leukemia/lymphoma (ATLL), a disease caused by human T-cell lymphotropic virus type-1 (HTLV-1). At admission, a 46-year-old female presented with lymphadenomegaly, lymphocytosis, slight elevation of LDH blood level, and acid-alcohol resistant bacilli in sputum and was being treated for pulmonary tuberculosis (Tb). She had lymphocytosis in the previous 20 months. Serology for HTLV-1 was positive. Lymph node was infiltrated by medium-sized lymphocytes with scattered Hodgkin and Reed-Sternberg-like cells CD30+, CS1-4+, and CD79a+. Background cells were CD4+ and CD25+. A clinical diagnosis of favorable chronic ATLL was given. She was treated with chemotherapy but later progressed to acute ATLL and ultimately died. Hodgkin-like ATLL should be considered in the histological differential diagnosis with Hodgkin lymphoma since treatment and prognosis of these diseases are distinct. It is also important to search for HTLV-1 infection in patients with unexplained prolonged lymphocytosis.info:eu-repo/semantics/openAccessBrazilian Society of Infectious DiseasesBrazilian Journal of Infectious Diseases v.21 n.1 20172017-02-01info:eu-repo/semantics/reporttext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000100119en10.1016/j.bjid.2016.09.005 |
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Bittencourt,Achiléa L. Andrade,Agnes Carvalho Requião,Cristiane Arruda,Maria da Gloria Bomfim Araújo,Iguaracyra |
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Bittencourt,Achiléa L. Andrade,Agnes Carvalho Requião,Cristiane Arruda,Maria da Gloria Bomfim Araújo,Iguaracyra Prolonged lymphocytosis as the first manifestation of Hodgkin-like adult T-cell leukemia/lymphoma |
author_facet |
Bittencourt,Achiléa L. Andrade,Agnes Carvalho Requião,Cristiane Arruda,Maria da Gloria Bomfim Araújo,Iguaracyra |
author_sort |
Bittencourt,Achiléa L. |
title |
Prolonged lymphocytosis as the first manifestation of Hodgkin-like adult T-cell leukemia/lymphoma |
title_short |
Prolonged lymphocytosis as the first manifestation of Hodgkin-like adult T-cell leukemia/lymphoma |
title_full |
Prolonged lymphocytosis as the first manifestation of Hodgkin-like adult T-cell leukemia/lymphoma |
title_fullStr |
Prolonged lymphocytosis as the first manifestation of Hodgkin-like adult T-cell leukemia/lymphoma |
title_full_unstemmed |
Prolonged lymphocytosis as the first manifestation of Hodgkin-like adult T-cell leukemia/lymphoma |
title_sort |
prolonged lymphocytosis as the first manifestation of hodgkin-like adult t-cell leukemia/lymphoma |
description |
Abstract Hodgkin-like ATLL is a rare variant of adult T-cell leukemia/lymphoma (ATLL), a disease caused by human T-cell lymphotropic virus type-1 (HTLV-1). At admission, a 46-year-old female presented with lymphadenomegaly, lymphocytosis, slight elevation of LDH blood level, and acid-alcohol resistant bacilli in sputum and was being treated for pulmonary tuberculosis (Tb). She had lymphocytosis in the previous 20 months. Serology for HTLV-1 was positive. Lymph node was infiltrated by medium-sized lymphocytes with scattered Hodgkin and Reed-Sternberg-like cells CD30+, CS1-4+, and CD79a+. Background cells were CD4+ and CD25+. A clinical diagnosis of favorable chronic ATLL was given. She was treated with chemotherapy but later progressed to acute ATLL and ultimately died. Hodgkin-like ATLL should be considered in the histological differential diagnosis with Hodgkin lymphoma since treatment and prognosis of these diseases are distinct. It is also important to search for HTLV-1 infection in patients with unexplained prolonged lymphocytosis. |
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Brazilian Society of Infectious Diseases |
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2017 |
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http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000100119 |
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