Influence of sexual hormones on Chagas disease
Abstract Objective: Analyze sex hormone's influence during Chagas disease. Methods: Male and female BALB/c mice were divided into six groups, four experimental (sham, orchiectomized, orchiectomized and supplemented with estradiol, orchiectomized supplemented with testosterone, oophorectomized, oophorectomized and supplemented with estradiol, and oophorectomized and supplemented with testosterone), and two control (healthy and intraperitoneally with T. cruzi strain NINOA infected). Clinical data were recorded daily, parasitemia was evaluated using a Neubauer chamber during the infection, and heart histopathological analysis was performed using the paraffin embedding technique. To analyze parasitemia curves and the area under the parametric curves, two-way ANOVA test was performed to correlate groups' data. P-values < 0.05 were considered statistically significant. Results: Higher mortality rates, cardiomegaly, hepatomegaly, ascites, edema, higher parasitemia levels, more amastigote nests, and more severe inflammatory infiltrate were found in higher testosterone concentration mice, whereas in higher estradiol concentration groups, paresia, prostration, edema, and necrosis were found. Conclusions: Our results showed that testosterone increased infection severity, whereas estradiol had the opposite effect. This research improves the understanding of sex hormones´ infuence upon this infection to contribute with the handling of Chagas´ disease.
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Instituto Nacional de Cardiología Ignacio Chávez
2024
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oai:scielo:S1405-994020240002001272024-05-07Influence of sexual hormones on Chagas diseaseReboreda-Hernández,Óscar A.Ortiz-Butron,RocíoNogueda-Torres,BenjaminGonzález-Rodríguez,Nayeli Chagas disease Estradiol Gonadal steroid hormones Testosterone Trypanosoma cruzi Abstract Objective: Analyze sex hormone's influence during Chagas disease. Methods: Male and female BALB/c mice were divided into six groups, four experimental (sham, orchiectomized, orchiectomized and supplemented with estradiol, orchiectomized supplemented with testosterone, oophorectomized, oophorectomized and supplemented with estradiol, and oophorectomized and supplemented with testosterone), and two control (healthy and intraperitoneally with T. cruzi strain NINOA infected). Clinical data were recorded daily, parasitemia was evaluated using a Neubauer chamber during the infection, and heart histopathological analysis was performed using the paraffin embedding technique. To analyze parasitemia curves and the area under the parametric curves, two-way ANOVA test was performed to correlate groups' data. P-values < 0.05 were considered statistically significant. Results: Higher mortality rates, cardiomegaly, hepatomegaly, ascites, edema, higher parasitemia levels, more amastigote nests, and more severe inflammatory infiltrate were found in higher testosterone concentration mice, whereas in higher estradiol concentration groups, paresia, prostration, edema, and necrosis were found. Conclusions: Our results showed that testosterone increased infection severity, whereas estradiol had the opposite effect. This research improves the understanding of sex hormones´ infuence upon this infection to contribute with the handling of Chagas´ disease.info:eu-repo/semantics/openAccessInstituto Nacional de Cardiología Ignacio ChávezArchivos de cardiología de México v.94 n.2 20242024-06-01info:eu-repo/semantics/articletext/htmlhttp://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1405-99402024000200127en10.24875/acm.23000018 |
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Reboreda-Hernández,Óscar A. Ortiz-Butron,Rocío Nogueda-Torres,Benjamin González-Rodríguez,Nayeli |
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Reboreda-Hernández,Óscar A. Ortiz-Butron,Rocío Nogueda-Torres,Benjamin González-Rodríguez,Nayeli Influence of sexual hormones on Chagas disease |
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Reboreda-Hernández,Óscar A. Ortiz-Butron,Rocío Nogueda-Torres,Benjamin González-Rodríguez,Nayeli |
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Reboreda-Hernández,Óscar A. |
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Influence of sexual hormones on Chagas disease |
title_short |
Influence of sexual hormones on Chagas disease |
title_full |
Influence of sexual hormones on Chagas disease |
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Influence of sexual hormones on Chagas disease |
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Influence of sexual hormones on Chagas disease |
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influence of sexual hormones on chagas disease |
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Abstract Objective: Analyze sex hormone's influence during Chagas disease. Methods: Male and female BALB/c mice were divided into six groups, four experimental (sham, orchiectomized, orchiectomized and supplemented with estradiol, orchiectomized supplemented with testosterone, oophorectomized, oophorectomized and supplemented with estradiol, and oophorectomized and supplemented with testosterone), and two control (healthy and intraperitoneally with T. cruzi strain NINOA infected). Clinical data were recorded daily, parasitemia was evaluated using a Neubauer chamber during the infection, and heart histopathological analysis was performed using the paraffin embedding technique. To analyze parasitemia curves and the area under the parametric curves, two-way ANOVA test was performed to correlate groups' data. P-values < 0.05 were considered statistically significant. Results: Higher mortality rates, cardiomegaly, hepatomegaly, ascites, edema, higher parasitemia levels, more amastigote nests, and more severe inflammatory infiltrate were found in higher testosterone concentration mice, whereas in higher estradiol concentration groups, paresia, prostration, edema, and necrosis were found. Conclusions: Our results showed that testosterone increased infection severity, whereas estradiol had the opposite effect. This research improves the understanding of sex hormones´ infuence upon this infection to contribute with the handling of Chagas´ disease. |
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Instituto Nacional de Cardiología Ignacio Chávez |
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2024 |
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http://www.scielo.org.mx/scielo.php?script=sci_arttext&pid=S1405-99402024000200127 |
work_keys_str_mv |
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