Impact of orocecal transit time on patient's perception of lactose intolerance

Background: symptoms attributed to the lactose intolerance are an important public health issue because of their prevalence and social relevance. Also because they may cause undue rejection of dairy products consume with potential health consequences. Transit time is a putative factor implied in the severity of symptoms associated with lactose. Objectives: to elucidate the relation between orocecal transit time (OCTT) and lactose intolerance symptoms. Methods: observational study in patients referred to a lactose hydrogen breath test who showed an increase in breath H2 excretion higher than 25 ppm. OCTT was measured with the breath test and symptoms of lactose tolerance with a validated scale. Symptoms were measured twice: before receiving the lactose, inquiring about self perceived symptoms when patients consumed dairy products at home ("home symptoms"), and again after completing the lactose breath test ("test symptoms"). Results: 161 patients were included. There was no correlation between OCTT and home symptoms (r = -0.1). When OCTT was faster than 60 minutes, intensity of "test symptoms" was similar to "home symptoms". However, in patients with normal or slow OCTT, the "home symptoms" were more intense than the "test symptoms" (p < 0.05). At home, symptoms were independent of OCTT but with the lactose test load the symptoms were proportionately more intense with faster OCTT. Conclusions: in lactose maldigesters, selfreported symptoms of lactose intolerance are more pronounced at home than after a high lactose challenge. Intolerance symptoms that patients attributed to lactose consume at home are due to factors other than fast OCTT.

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Main Authors: Casellas,Francesc, Aparici,Anna, Casaus,Maite, Rodríguez,Purificación, Malagelada,Juan R.
Format: Digital revista
Language:English
Published: Sociedad Española de Patología Digestiva 2013
Online Access:http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082013000100004
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spelling oai:scielo:S1130-010820130001000042013-05-21Impact of orocecal transit time on patient's perception of lactose intoleranceCasellas,FrancescAparici,AnnaCasaus,MaiteRodríguez,PurificaciónMalagelada,Juan R. Lactose intolerance Lactose malabsorption Hydrogen breath test Lactase activity Transit time Orocecal transit time Background: symptoms attributed to the lactose intolerance are an important public health issue because of their prevalence and social relevance. Also because they may cause undue rejection of dairy products consume with potential health consequences. Transit time is a putative factor implied in the severity of symptoms associated with lactose. Objectives: to elucidate the relation between orocecal transit time (OCTT) and lactose intolerance symptoms. Methods: observational study in patients referred to a lactose hydrogen breath test who showed an increase in breath H2 excretion higher than 25 ppm. OCTT was measured with the breath test and symptoms of lactose tolerance with a validated scale. Symptoms were measured twice: before receiving the lactose, inquiring about self perceived symptoms when patients consumed dairy products at home ("home symptoms"), and again after completing the lactose breath test ("test symptoms"). Results: 161 patients were included. There was no correlation between OCTT and home symptoms (r = -0.1). When OCTT was faster than 60 minutes, intensity of "test symptoms" was similar to "home symptoms". However, in patients with normal or slow OCTT, the "home symptoms" were more intense than the "test symptoms" (p < 0.05). At home, symptoms were independent of OCTT but with the lactose test load the symptoms were proportionately more intense with faster OCTT. Conclusions: in lactose maldigesters, selfreported symptoms of lactose intolerance are more pronounced at home than after a high lactose challenge. Intolerance symptoms that patients attributed to lactose consume at home are due to factors other than fast OCTT.Sociedad Española de Patología DigestivaRevista Española de Enfermedades Digestivas v.105 n.1 20132013-01-01journal articletext/htmlhttp://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082013000100004en
institution SCIELO
collection OJS
country España
countrycode ES
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databasecode rev-scielo-es
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region Europa del Sur
libraryname SciELO
language English
format Digital
author Casellas,Francesc
Aparici,Anna
Casaus,Maite
Rodríguez,Purificación
Malagelada,Juan R.
spellingShingle Casellas,Francesc
Aparici,Anna
Casaus,Maite
Rodríguez,Purificación
Malagelada,Juan R.
Impact of orocecal transit time on patient's perception of lactose intolerance
author_facet Casellas,Francesc
Aparici,Anna
Casaus,Maite
Rodríguez,Purificación
Malagelada,Juan R.
author_sort Casellas,Francesc
title Impact of orocecal transit time on patient's perception of lactose intolerance
title_short Impact of orocecal transit time on patient's perception of lactose intolerance
title_full Impact of orocecal transit time on patient's perception of lactose intolerance
title_fullStr Impact of orocecal transit time on patient's perception of lactose intolerance
title_full_unstemmed Impact of orocecal transit time on patient's perception of lactose intolerance
title_sort impact of orocecal transit time on patient's perception of lactose intolerance
description Background: symptoms attributed to the lactose intolerance are an important public health issue because of their prevalence and social relevance. Also because they may cause undue rejection of dairy products consume with potential health consequences. Transit time is a putative factor implied in the severity of symptoms associated with lactose. Objectives: to elucidate the relation between orocecal transit time (OCTT) and lactose intolerance symptoms. Methods: observational study in patients referred to a lactose hydrogen breath test who showed an increase in breath H2 excretion higher than 25 ppm. OCTT was measured with the breath test and symptoms of lactose tolerance with a validated scale. Symptoms were measured twice: before receiving the lactose, inquiring about self perceived symptoms when patients consumed dairy products at home ("home symptoms"), and again after completing the lactose breath test ("test symptoms"). Results: 161 patients were included. There was no correlation between OCTT and home symptoms (r = -0.1). When OCTT was faster than 60 minutes, intensity of "test symptoms" was similar to "home symptoms". However, in patients with normal or slow OCTT, the "home symptoms" were more intense than the "test symptoms" (p < 0.05). At home, symptoms were independent of OCTT but with the lactose test load the symptoms were proportionately more intense with faster OCTT. Conclusions: in lactose maldigesters, selfreported symptoms of lactose intolerance are more pronounced at home than after a high lactose challenge. Intolerance symptoms that patients attributed to lactose consume at home are due to factors other than fast OCTT.
publisher Sociedad Española de Patología Digestiva
publishDate 2013
url http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082013000100004
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