SYNTHESIS AND ANTIMICROBIAL STUDY OF NEW BENZIMIDAZOLE SCHIFF BASES BEARING P-TOLUENE SULFONAMIDE MOIETY

SYNTHESIS AND ANTIMICROBIAL STUDY OF NEW BENZIMIDAZOLE SCHIFF BASES BEARING P-TOLUENE SULFONAMIDE MOIETY

ABSTRACT Three new Schiff bases bearing benzimidazole and p-toluen sulfonamide moiety were synthesized. Their structures were characterized by elemental analysis, FTIR, NMR and LCMS methods. The antimicrobial properties of the compounds were also evaluated. All compounds exhibit higher antimicrobial activity against all bacteria, Schiff bases (4a-4c) shows more activity than the parent aldehyde (3). 4c displays higher antibacterial activity against P. aeruginosa compare to reference drug Sulfioxazole. The compounds were found more potent against Gram-negative than Gram positive bacteria. One more free phenyl group increase the activity in 4c, but one more phenyl ring in 4b does not. In vitro antifungal activity of the compounds was also tested on fungi C. albicans C. tropicalis and C. krusei. However, our compounds exhibit no antifungal activity against three fungi.

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Main Author: Tunc,Turgay
Format: Digital revista
Language:English
Published: Sociedad Chilena de Química 2019
Online Access:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072019000404590
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spelling oai:scielo:S0717-970720190004045902020-02-03SYNTHESIS AND ANTIMICROBIAL STUDY OF NEW BENZIMIDAZOLE SCHIFF BASES BEARING P-TOLUENE SULFONAMIDE MOIETYTunc,Turgay Benzimidazole Schiff bases antimicrobial activity ABSTRACT Three new Schiff bases bearing benzimidazole and p-toluen sulfonamide moiety were synthesized. Their structures were characterized by elemental analysis, FTIR, NMR and LCMS methods. The antimicrobial properties of the compounds were also evaluated. All compounds exhibit higher antimicrobial activity against all bacteria, Schiff bases (4a-4c) shows more activity than the parent aldehyde (3). 4c displays higher antibacterial activity against P. aeruginosa compare to reference drug Sulfioxazole. The compounds were found more potent against Gram-negative than Gram positive bacteria. One more free phenyl group increase the activity in 4c, but one more phenyl ring in 4b does not. In vitro antifungal activity of the compounds was also tested on fungi C. albicans C. tropicalis and C. krusei. However, our compounds exhibit no antifungal activity against three fungi.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.64 n.4 20192019-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072019000404590en10.4067/S0717-97072019000404590
institution SCIELO
collection OJS
country Chile
countrycode CL
component Revista
access En linea
databasecode rev-scielo-cl
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author Tunc,Turgay
spellingShingle Tunc,Turgay
SYNTHESIS AND ANTIMICROBIAL STUDY OF NEW BENZIMIDAZOLE SCHIFF BASES BEARING P-TOLUENE SULFONAMIDE MOIETY
author_facet Tunc,Turgay
author_sort Tunc,Turgay
title SYNTHESIS AND ANTIMICROBIAL STUDY OF NEW BENZIMIDAZOLE SCHIFF BASES BEARING P-TOLUENE SULFONAMIDE MOIETY
title_short SYNTHESIS AND ANTIMICROBIAL STUDY OF NEW BENZIMIDAZOLE SCHIFF BASES BEARING P-TOLUENE SULFONAMIDE MOIETY
title_full SYNTHESIS AND ANTIMICROBIAL STUDY OF NEW BENZIMIDAZOLE SCHIFF BASES BEARING P-TOLUENE SULFONAMIDE MOIETY
title_fullStr SYNTHESIS AND ANTIMICROBIAL STUDY OF NEW BENZIMIDAZOLE SCHIFF BASES BEARING P-TOLUENE SULFONAMIDE MOIETY
title_full_unstemmed SYNTHESIS AND ANTIMICROBIAL STUDY OF NEW BENZIMIDAZOLE SCHIFF BASES BEARING P-TOLUENE SULFONAMIDE MOIETY
title_sort synthesis and antimicrobial study of new benzimidazole schiff bases bearing p-toluene sulfonamide moiety
description ABSTRACT Three new Schiff bases bearing benzimidazole and p-toluen sulfonamide moiety were synthesized. Their structures were characterized by elemental analysis, FTIR, NMR and LCMS methods. The antimicrobial properties of the compounds were also evaluated. All compounds exhibit higher antimicrobial activity against all bacteria, Schiff bases (4a-4c) shows more activity than the parent aldehyde (3). 4c displays higher antibacterial activity against P. aeruginosa compare to reference drug Sulfioxazole. The compounds were found more potent against Gram-negative than Gram positive bacteria. One more free phenyl group increase the activity in 4c, but one more phenyl ring in 4b does not. In vitro antifungal activity of the compounds was also tested on fungi C. albicans C. tropicalis and C. krusei. However, our compounds exhibit no antifungal activity against three fungi.
publisher Sociedad Chilena de Química
publishDate 2019
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072019000404590
work_keys_str_mv AT tuncturgay synthesisandantimicrobialstudyofnewbenzimidazoleschiffbasesbearingptoluenesulfonamidemoiety
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