pH DEPENDENT DRUG DELIVERY BASED ON SILICA XEROGEL

pH DEPENDENT DRUG DELIVERY BASED ON SILICA XEROGEL

ABSTRACT In this work, a matrix based on silica xerogel, synthesized from TEOS, water, ibuprofen (as template) and acetic acid at room temperature, was used for ibuprofen (IBF) incorporation, aiming to create a drug delivery system capable of releasing this compound under a basic pH condition (considering desirable and optimal release in the intestines). The IBF release was checked at different pH values (ranging from 2 to 8), using appropriate buffered solutions. After observing the IBF release performance from the silica xerogel and its dependence on the pH, the same matrix containing IBF was submitted to a novel assay, using only a pH 7 buffered solution as the best way to check the chronological release. This was carried out at 1, 2, 5 and 10 minutes to determine aliquot removal, as well as IBF concentration at each elapsed period.

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Main Authors: VASCONCELOS,AÉCIO B. P. DE, SILVA,WAGNER E., BELIAN,MÔNICA F.
Format: Digital revista
Language:English
Published: Sociedad Chilena de Química 2017
Online Access:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072017000403700
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spelling oai:scielo:S0717-970720170004037002018-04-02pH DEPENDENT DRUG DELIVERY BASED ON SILICA XEROGELVASCONCELOS,AÉCIO B. P. DESILVA,WAGNER E.BELIAN,MÔNICA F. silica xerogel pH-dependent release ibuprofen ABSTRACT In this work, a matrix based on silica xerogel, synthesized from TEOS, water, ibuprofen (as template) and acetic acid at room temperature, was used for ibuprofen (IBF) incorporation, aiming to create a drug delivery system capable of releasing this compound under a basic pH condition (considering desirable and optimal release in the intestines). The IBF release was checked at different pH values (ranging from 2 to 8), using appropriate buffered solutions. After observing the IBF release performance from the silica xerogel and its dependence on the pH, the same matrix containing IBF was submitted to a novel assay, using only a pH 7 buffered solution as the best way to check the chronological release. This was carried out at 1, 2, 5 and 10 minutes to determine aliquot removal, as well as IBF concentration at each elapsed period.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.62 n.4 20172017-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072017000403700en10.4067/s0717-97072017000403700
institution SCIELO
collection OJS
country Chile
countrycode CL
component Revista
access En linea
databasecode rev-scielo-cl
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author VASCONCELOS,AÉCIO B. P. DE
SILVA,WAGNER E.
BELIAN,MÔNICA F.
spellingShingle VASCONCELOS,AÉCIO B. P. DE
SILVA,WAGNER E.
BELIAN,MÔNICA F.
pH DEPENDENT DRUG DELIVERY BASED ON SILICA XEROGEL
author_facet VASCONCELOS,AÉCIO B. P. DE
SILVA,WAGNER E.
BELIAN,MÔNICA F.
author_sort VASCONCELOS,AÉCIO B. P. DE
title pH DEPENDENT DRUG DELIVERY BASED ON SILICA XEROGEL
title_short pH DEPENDENT DRUG DELIVERY BASED ON SILICA XEROGEL
title_full pH DEPENDENT DRUG DELIVERY BASED ON SILICA XEROGEL
title_fullStr pH DEPENDENT DRUG DELIVERY BASED ON SILICA XEROGEL
title_full_unstemmed pH DEPENDENT DRUG DELIVERY BASED ON SILICA XEROGEL
title_sort ph dependent drug delivery based on silica xerogel
description ABSTRACT In this work, a matrix based on silica xerogel, synthesized from TEOS, water, ibuprofen (as template) and acetic acid at room temperature, was used for ibuprofen (IBF) incorporation, aiming to create a drug delivery system capable of releasing this compound under a basic pH condition (considering desirable and optimal release in the intestines). The IBF release was checked at different pH values (ranging from 2 to 8), using appropriate buffered solutions. After observing the IBF release performance from the silica xerogel and its dependence on the pH, the same matrix containing IBF was submitted to a novel assay, using only a pH 7 buffered solution as the best way to check the chronological release. This was carried out at 1, 2, 5 and 10 minutes to determine aliquot removal, as well as IBF concentration at each elapsed period.
publisher Sociedad Chilena de Química
publishDate 2017
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072017000403700
work_keys_str_mv AT vasconcelosaeciobpde phdependentdrugdeliverybasedonsilicaxerogel
AT silvawagnere phdependentdrugdeliverybasedonsilicaxerogel
AT belianmonicaf phdependentdrugdeliverybasedonsilicaxerogel
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