NEW APPROACHES FOR THE SYNTHESIS OF HYDRAZONE DERIVATIVES AND THEIR ANTITUMOR EVALUATION

NEW APPROACHES FOR THE SYNTHESIS OF HYDRAZONE DERIVATIVES AND THEIR ANTITUMOR EVALUATION

The hydrazide-hydrazone 3 reacted with benzenediazonium chloride to give the phenylhydrazone derivative 5. The latter underwent a series of hetero-cyclization reactions to give pyridazine, 1,2,3-triazole and pyrazole derivatives. The antitumor evaluation of the newly synthesized products against the three cancer cells lines namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) showed that some of them have higher inhibitory effects towards the three cell lines compared to the standard.

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Main Authors: WARDAKHAN,WAGNAT WAHBA, SAMIR,EMAN MOHAMED
Format: Digital revista
Language:English
Published: Sociedad Chilena de Química 2012
Online Access:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000200013
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spelling oai:scielo:S0717-970720120002000132014-03-10NEW APPROACHES FOR THE SYNTHESIS OF HYDRAZONE DERIVATIVES AND THEIR ANTITUMOR EVALUATIONWARDAKHAN,WAGNAT WAHBASAMIR,EMAN MOHAMED hydrazide-hydrazone pyridazine 1,2,3-triazole pyrazole anti-tumor The hydrazide-hydrazone 3 reacted with benzenediazonium chloride to give the phenylhydrazone derivative 5. The latter underwent a series of hetero-cyclization reactions to give pyridazine, 1,2,3-triazole and pyrazole derivatives. The antitumor evaluation of the newly synthesized products against the three cancer cells lines namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) showed that some of them have higher inhibitory effects towards the three cell lines compared to the standard.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.57 n.2 20122012-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000200013en10.4067/S0717-97072012000200013
institution SCIELO
collection OJS
country Chile
countrycode CL
component Revista
access En linea
databasecode rev-scielo-cl
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author WARDAKHAN,WAGNAT WAHBA
SAMIR,EMAN MOHAMED
spellingShingle WARDAKHAN,WAGNAT WAHBA
SAMIR,EMAN MOHAMED
NEW APPROACHES FOR THE SYNTHESIS OF HYDRAZONE DERIVATIVES AND THEIR ANTITUMOR EVALUATION
author_facet WARDAKHAN,WAGNAT WAHBA
SAMIR,EMAN MOHAMED
author_sort WARDAKHAN,WAGNAT WAHBA
title NEW APPROACHES FOR THE SYNTHESIS OF HYDRAZONE DERIVATIVES AND THEIR ANTITUMOR EVALUATION
title_short NEW APPROACHES FOR THE SYNTHESIS OF HYDRAZONE DERIVATIVES AND THEIR ANTITUMOR EVALUATION
title_full NEW APPROACHES FOR THE SYNTHESIS OF HYDRAZONE DERIVATIVES AND THEIR ANTITUMOR EVALUATION
title_fullStr NEW APPROACHES FOR THE SYNTHESIS OF HYDRAZONE DERIVATIVES AND THEIR ANTITUMOR EVALUATION
title_full_unstemmed NEW APPROACHES FOR THE SYNTHESIS OF HYDRAZONE DERIVATIVES AND THEIR ANTITUMOR EVALUATION
title_sort new approaches for the synthesis of hydrazone derivatives and their antitumor evaluation
description The hydrazide-hydrazone 3 reacted with benzenediazonium chloride to give the phenylhydrazone derivative 5. The latter underwent a series of hetero-cyclization reactions to give pyridazine, 1,2,3-triazole and pyrazole derivatives. The antitumor evaluation of the newly synthesized products against the three cancer cells lines namely breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and CNS cancer (SF-268) showed that some of them have higher inhibitory effects towards the three cell lines compared to the standard.
publisher Sociedad Chilena de Química
publishDate 2012
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072012000200013
work_keys_str_mv AT wardakhanwagnatwahba newapproachesforthesynthesisofhydrazonederivativesandtheirantitumorevaluation
AT samiremanmohamed newapproachesforthesynthesisofhydrazonederivativesandtheirantitumorevaluation
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