SYNTHESIS AND EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF SOME NEW MANNICH BASES BEARING BENZTRIAZOLE MOIETY
A series of benztriazoles bearing Mannich bases (2 -10) were synthesized from benztriazole by aminomethylation with formaldehyde and various substituted secondary amines. Titled compounds were synthesized by Mannich reaction and they were characterized by IR and ¹HNMR spectroscopy. All these Mannich bases were screened for hepatoprotective activity on carbon tetrachloride induced liver damage in rats. Only compounds 4 (250 mg/kg) protected significantly the animals from carbon tetrachloride induced hepatotoxicity. Compound 4 N-morpholinyl methyl benztriazole exhibited significant activity comparable to that of standard drug silymarin.
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Digital revista |
| Language: | English |
| Published: |
Sociedad Chilena de Química
2010
|
| Online Access: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000300021 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| id |
oai:scielo:S0717-97072010000300021 |
|---|---|
| record_format |
ojs |
| spelling |
oai:scielo:S0717-970720100003000212011-01-25SYNTHESIS AND EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF SOME NEW MANNICH BASES BEARING BENZTRIAZOLE MOIETYRAJASEKARAN,AIYALUPERIYASAMY,MUTHUSAMY Mannich bases benztriazoles hepatoprotective Serum Glutamate Oxaloacetate Transaminase Serum Glutamate Pyruvate Transaminase Alkaline Phosphatase A series of benztriazoles bearing Mannich bases (2 -10) were synthesized from benztriazole by aminomethylation with formaldehyde and various substituted secondary amines. Titled compounds were synthesized by Mannich reaction and they were characterized by IR and ¹HNMR spectroscopy. All these Mannich bases were screened for hepatoprotective activity on carbon tetrachloride induced liver damage in rats. Only compounds 4 (250 mg/kg) protected significantly the animals from carbon tetrachloride induced hepatotoxicity. Compound 4 N-morpholinyl methyl benztriazole exhibited significant activity comparable to that of standard drug silymarin.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.55 n.3 20102010-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000300021en10.4067/S0717-97072010000300021 |
| institution |
SCIELO |
| collection |
OJS |
| country |
Chile |
| countrycode |
CL |
| component |
Revista |
| access |
En linea |
| databasecode |
rev-scielo-cl |
| tag |
revista |
| region |
America del Sur |
| libraryname |
SciELO |
| language |
English |
| format |
Digital |
| author |
RAJASEKARAN,AIYALU PERIYASAMY,MUTHUSAMY |
| spellingShingle |
RAJASEKARAN,AIYALU PERIYASAMY,MUTHUSAMY SYNTHESIS AND EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF SOME NEW MANNICH BASES BEARING BENZTRIAZOLE MOIETY |
| author_facet |
RAJASEKARAN,AIYALU PERIYASAMY,MUTHUSAMY |
| author_sort |
RAJASEKARAN,AIYALU |
| title |
SYNTHESIS AND EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF SOME NEW MANNICH BASES BEARING BENZTRIAZOLE MOIETY |
| title_short |
SYNTHESIS AND EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF SOME NEW MANNICH BASES BEARING BENZTRIAZOLE MOIETY |
| title_full |
SYNTHESIS AND EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF SOME NEW MANNICH BASES BEARING BENZTRIAZOLE MOIETY |
| title_fullStr |
SYNTHESIS AND EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF SOME NEW MANNICH BASES BEARING BENZTRIAZOLE MOIETY |
| title_full_unstemmed |
SYNTHESIS AND EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF SOME NEW MANNICH BASES BEARING BENZTRIAZOLE MOIETY |
| title_sort |
synthesis and evaluation of hepatoprotective activity of some new mannich bases bearing benztriazole moiety |
| description |
A series of benztriazoles bearing Mannich bases (2 -10) were synthesized from benztriazole by aminomethylation with formaldehyde and various substituted secondary amines. Titled compounds were synthesized by Mannich reaction and they were characterized by IR and ¹HNMR spectroscopy. All these Mannich bases were screened for hepatoprotective activity on carbon tetrachloride induced liver damage in rats. Only compounds 4 (250 mg/kg) protected significantly the animals from carbon tetrachloride induced hepatotoxicity. Compound 4 N-morpholinyl methyl benztriazole exhibited significant activity comparable to that of standard drug silymarin. |
| publisher |
Sociedad Chilena de Química |
| publishDate |
2010 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000300021 |
| work_keys_str_mv |
AT rajasekaranaiyalu synthesisandevaluationofhepatoprotectiveactivityofsomenewmannichbasesbearingbenztriazolemoiety AT periyasamymuthusamy synthesisandevaluationofhepatoprotectiveactivityofsomenewmannichbasesbearingbenztriazolemoiety |
| _version_ |
1755993453245759488 |