SYNTHESIS AND MICROBIOLOGICAL EVALUATION OF MANNICH BASES DERIVED FROM 4,6-DIACETYLRESORCINOL
In the present investigations 4,6-diacetyl resorcinol 1 on condensation with formaldehyde and some selected amines following the Mannich reaction conditions yielded eight new Mannich bases 2a-h. It was observed that the reaction did not take place at the acetyl function but occurred at the 2-position into the aromatic ring. The compounds were characterized on the basis of elemental analysis as well as ¹H NMR and Mass spectral data. The antibacterial and antifungal activities of the title compounds were tested by the disc diffusion method using nutrient agar medium against various microorganisms such as gram positive Staphylococcus aureus and Bacillus subtilis, gram negative Escherichia coli and the fungi Aspergillus flavus and Candida albicans. Ofloxacin and voriconazole at 20 ug/mL were used as standard drugs for antibacterial and antifungal activities, respectively.
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Digital revista |
| Language: | English |
| Published: |
Sociedad Chilena de Química
2010
|
| Online Access: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000300012 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| id |
oai:scielo:S0717-97072010000300012 |
|---|---|
| record_format |
ojs |
| spelling |
oai:scielo:S0717-970720100003000122011-01-25SYNTHESIS AND MICROBIOLOGICAL EVALUATION OF MANNICH BASES DERIVED FROM 4,6-DIACETYLRESORCINOLHUSAIN,ASIFMAAZ,MOHAMMADAHMAD ANSARI,KHURSHEEDAHMAD,AUSAFRASHID,MOHD Mannich base resorcinol antibacterial antifungal In the present investigations 4,6-diacetyl resorcinol 1 on condensation with formaldehyde and some selected amines following the Mannich reaction conditions yielded eight new Mannich bases 2a-h. It was observed that the reaction did not take place at the acetyl function but occurred at the 2-position into the aromatic ring. The compounds were characterized on the basis of elemental analysis as well as ¹H NMR and Mass spectral data. The antibacterial and antifungal activities of the title compounds were tested by the disc diffusion method using nutrient agar medium against various microorganisms such as gram positive Staphylococcus aureus and Bacillus subtilis, gram negative Escherichia coli and the fungi Aspergillus flavus and Candida albicans. Ofloxacin and voriconazole at 20 ug/mL were used as standard drugs for antibacterial and antifungal activities, respectively.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.55 n.3 20102010-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000300012en10.4067/S0717-97072010000300012 |
| institution |
SCIELO |
| collection |
OJS |
| country |
Chile |
| countrycode |
CL |
| component |
Revista |
| access |
En linea |
| databasecode |
rev-scielo-cl |
| tag |
revista |
| region |
America del Sur |
| libraryname |
SciELO |
| language |
English |
| format |
Digital |
| author |
HUSAIN,ASIF MAAZ,MOHAMMAD AHMAD ANSARI,KHURSHEED AHMAD,AUSAF RASHID,MOHD |
| spellingShingle |
HUSAIN,ASIF MAAZ,MOHAMMAD AHMAD ANSARI,KHURSHEED AHMAD,AUSAF RASHID,MOHD SYNTHESIS AND MICROBIOLOGICAL EVALUATION OF MANNICH BASES DERIVED FROM 4,6-DIACETYLRESORCINOL |
| author_facet |
HUSAIN,ASIF MAAZ,MOHAMMAD AHMAD ANSARI,KHURSHEED AHMAD,AUSAF RASHID,MOHD |
| author_sort |
HUSAIN,ASIF |
| title |
SYNTHESIS AND MICROBIOLOGICAL EVALUATION OF MANNICH BASES DERIVED FROM 4,6-DIACETYLRESORCINOL |
| title_short |
SYNTHESIS AND MICROBIOLOGICAL EVALUATION OF MANNICH BASES DERIVED FROM 4,6-DIACETYLRESORCINOL |
| title_full |
SYNTHESIS AND MICROBIOLOGICAL EVALUATION OF MANNICH BASES DERIVED FROM 4,6-DIACETYLRESORCINOL |
| title_fullStr |
SYNTHESIS AND MICROBIOLOGICAL EVALUATION OF MANNICH BASES DERIVED FROM 4,6-DIACETYLRESORCINOL |
| title_full_unstemmed |
SYNTHESIS AND MICROBIOLOGICAL EVALUATION OF MANNICH BASES DERIVED FROM 4,6-DIACETYLRESORCINOL |
| title_sort |
synthesis and microbiological evaluation of mannich bases derived from 4,6-diacetylresorcinol |
| description |
In the present investigations 4,6-diacetyl resorcinol 1 on condensation with formaldehyde and some selected amines following the Mannich reaction conditions yielded eight new Mannich bases 2a-h. It was observed that the reaction did not take place at the acetyl function but occurred at the 2-position into the aromatic ring. The compounds were characterized on the basis of elemental analysis as well as ¹H NMR and Mass spectral data. The antibacterial and antifungal activities of the title compounds were tested by the disc diffusion method using nutrient agar medium against various microorganisms such as gram positive Staphylococcus aureus and Bacillus subtilis, gram negative Escherichia coli and the fungi Aspergillus flavus and Candida albicans. Ofloxacin and voriconazole at 20 ug/mL were used as standard drugs for antibacterial and antifungal activities, respectively. |
| publisher |
Sociedad Chilena de Química |
| publishDate |
2010 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072010000300012 |
| work_keys_str_mv |
AT husainasif synthesisandmicrobiologicalevaluationofmannichbasesderivedfrom46diacetylresorcinol AT maazmohammad synthesisandmicrobiologicalevaluationofmannichbasesderivedfrom46diacetylresorcinol AT ahmadansarikhursheed synthesisandmicrobiologicalevaluationofmannichbasesderivedfrom46diacetylresorcinol AT ahmadausaf synthesisandmicrobiologicalevaluationofmannichbasesderivedfrom46diacetylresorcinol AT rashidmohd synthesisandmicrobiologicalevaluationofmannichbasesderivedfrom46diacetylresorcinol |
| _version_ |
1755993452054577152 |