THE REACTION OF CYANOACETYLHYDRAZINE WITH w-BROMOACETOPHENONE: NOVEL SYNTHESIS OF 1,3,4-OXADIAZINE, PYRIDAZINE AND COUMARIN DERIVATIVES
The reaction of cyanoacetylhydrazine with co-bromoacetophenone gave the condensation product p-Bromoacetophenone-a-cyanoacetylhydrazone (3). The latter product underwent ready cyclization to give the 1,3,4-oxadiazine derivative 4. The reactivities of either 3 or 4 towards some chemical reagents like cyanomethylene reagents, diazonium salts, aromatic aldehydes, phenylisothio-cyanate and elemental sulfur were studied to afford 17 newly producís for which the toxicity towards Fusarium oxysporum f. sp. Lycopersici and Helminthosporium oryzea was measured. Moreover their effect towards mycelial dry mass, sporulation and nucleic acid synthesis of Fusarium oxysporum f. sp. Lycopersici was measured
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Sociedad Chilena de Química
2007
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oai:scielo:S0717-970720070001000052007-05-07THE REACTION OF CYANOACETYLHYDRAZINE WITH w-BROMOACETOPHENONE: NOVEL SYNTHESIS OF 1,3,4-OXADIAZINE, PYRIDAZINE AND COUMARIN DERIVATIVESMOHAREB,RAFAT MIBRAHIM,REHAB AHO,JONATHAN Z Cyanoacetylhydrazine 1,3,4-Oxadiazine Pyridazine Toxicity The reaction of cyanoacetylhydrazine with co-bromoacetophenone gave the condensation product p-Bromoacetophenone-a-cyanoacetylhydrazone (3). The latter product underwent ready cyclization to give the 1,3,4-oxadiazine derivative 4. The reactivities of either 3 or 4 towards some chemical reagents like cyanomethylene reagents, diazonium salts, aromatic aldehydes, phenylisothio-cyanate and elemental sulfur were studied to afford 17 newly producís for which the toxicity towards Fusarium oxysporum f. sp. Lycopersici and Helminthosporium oryzea was measured. Moreover their effect towards mycelial dry mass, sporulation and nucleic acid synthesis of Fusarium oxysporum f. sp. Lycopersici was measuredinfo:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.52 n.1 20072007-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072007000100005en10.4067/S0717-97072007000100005 |
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MOHAREB,RAFAT M IBRAHIM,REHAB A HO,JONATHAN Z |
| spellingShingle |
MOHAREB,RAFAT M IBRAHIM,REHAB A HO,JONATHAN Z THE REACTION OF CYANOACETYLHYDRAZINE WITH w-BROMOACETOPHENONE: NOVEL SYNTHESIS OF 1,3,4-OXADIAZINE, PYRIDAZINE AND COUMARIN DERIVATIVES |
| author_facet |
MOHAREB,RAFAT M IBRAHIM,REHAB A HO,JONATHAN Z |
| author_sort |
MOHAREB,RAFAT M |
| title |
THE REACTION OF CYANOACETYLHYDRAZINE WITH w-BROMOACETOPHENONE: NOVEL SYNTHESIS OF 1,3,4-OXADIAZINE, PYRIDAZINE AND COUMARIN DERIVATIVES |
| title_short |
THE REACTION OF CYANOACETYLHYDRAZINE WITH w-BROMOACETOPHENONE: NOVEL SYNTHESIS OF 1,3,4-OXADIAZINE, PYRIDAZINE AND COUMARIN DERIVATIVES |
| title_full |
THE REACTION OF CYANOACETYLHYDRAZINE WITH w-BROMOACETOPHENONE: NOVEL SYNTHESIS OF 1,3,4-OXADIAZINE, PYRIDAZINE AND COUMARIN DERIVATIVES |
| title_fullStr |
THE REACTION OF CYANOACETYLHYDRAZINE WITH w-BROMOACETOPHENONE: NOVEL SYNTHESIS OF 1,3,4-OXADIAZINE, PYRIDAZINE AND COUMARIN DERIVATIVES |
| title_full_unstemmed |
THE REACTION OF CYANOACETYLHYDRAZINE WITH w-BROMOACETOPHENONE: NOVEL SYNTHESIS OF 1,3,4-OXADIAZINE, PYRIDAZINE AND COUMARIN DERIVATIVES |
| title_sort |
reaction of cyanoacetylhydrazine with w-bromoacetophenone: novel synthesis of 1,3,4-oxadiazine, pyridazine and coumarin derivatives |
| description |
The reaction of cyanoacetylhydrazine with co-bromoacetophenone gave the condensation product p-Bromoacetophenone-a-cyanoacetylhydrazone (3). The latter product underwent ready cyclization to give the 1,3,4-oxadiazine derivative 4. The reactivities of either 3 or 4 towards some chemical reagents like cyanomethylene reagents, diazonium salts, aromatic aldehydes, phenylisothio-cyanate and elemental sulfur were studied to afford 17 newly producís for which the toxicity towards Fusarium oxysporum f. sp. Lycopersici and Helminthosporium oryzea was measured. Moreover their effect towards mycelial dry mass, sporulation and nucleic acid synthesis of Fusarium oxysporum f. sp. Lycopersici was measured |
| publisher |
Sociedad Chilena de Química |
| publishDate |
2007 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072007000100005 |
| work_keys_str_mv |
AT moharebrafatm thereactionofcyanoacetylhydrazinewithwbromoacetophenonenovelsynthesisof134oxadiazinepyridazineandcoumarinderivatives AT ibrahimrehaba thereactionofcyanoacetylhydrazinewithwbromoacetophenonenovelsynthesisof134oxadiazinepyridazineandcoumarinderivatives AT hojonathanz thereactionofcyanoacetylhydrazinewithwbromoacetophenonenovelsynthesisof134oxadiazinepyridazineandcoumarinderivatives AT moharebrafatm reactionofcyanoacetylhydrazinewithwbromoacetophenonenovelsynthesisof134oxadiazinepyridazineandcoumarinderivatives AT ibrahimrehaba reactionofcyanoacetylhydrazinewithwbromoacetophenonenovelsynthesisof134oxadiazinepyridazineandcoumarinderivatives AT hojonathanz reactionofcyanoacetylhydrazinewithwbromoacetophenonenovelsynthesisof134oxadiazinepyridazineandcoumarinderivatives |
| _version_ |
1755993406312546304 |