CHEMICAL BASIS FOR THE ANTIMICROBIAL ACTIVITY OF ACETANILIDES
In vitro antimicrobial activity of a series of substituted acetanilides against S. aureus, E. coli and C. albicans were measured at two concentrations, 250 mug/ml and 500 mug/ml. Only the structures substituted with halogens in Calpha and electron acceptors in the aromatic ring are bioactive. The results are rationalized in terms of the acid properties of the N-H bond, as calculated using AM1-MO theory
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| Main Authors: | , , , |
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| Format: | Digital revista |
| Language: | English |
| Published: |
Sociedad Chilena de Química
2003
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| Online Access: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072003000400005 |
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