Risk Factors for Recurrent Aphthous Stomatitis: A Systematic Review

Risk Factors for Recurrent Aphthous Stomatitis: A Systematic Review

SUMMARY: The cause and prevention of recurrent aphthous stomatitis (also called aphthous ulcers or canker sores) are still unknown. This may be due in part to ignorance of the risk factors present in susceptible people. In this systematic review (PROSPERO record #CRD42019122214), we show that most of the risk factors for the disease are single nucleotide genetic polymorphisms in genes related to the functioning of immune system (TLR4, MMP9, E-selectin, IL-1 beta and TNF-alpha). Single nucleotide genetic polymorphisms do not constitute a modifiable risk. This indicates that, at least in part, susceptibility to recurrent aphthous stomatitis is hereditary, and that these factors cannot be modified.

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Main Authors: Rivera,César, Muñoz,Antonieta, Puentes,Carolina, Aguayo,Esteban
Format: Digital revista
Language:English
Published: Sociedad Chilena de Anatomía 2021
Online Access:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000401102
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spelling oai:scielo:S0717-950220210004011022021-08-16Risk Factors for Recurrent Aphthous Stomatitis: A Systematic ReviewRivera,CésarMuñoz,AntonietaPuentes,CarolinaAguayo,Esteban Aphthous stomatitis Risk factors Genetic polymorphisms Multivariate analysis Systematic review. SUMMARY: The cause and prevention of recurrent aphthous stomatitis (also called aphthous ulcers or canker sores) are still unknown. This may be due in part to ignorance of the risk factors present in susceptible people. In this systematic review (PROSPERO record #CRD42019122214), we show that most of the risk factors for the disease are single nucleotide genetic polymorphisms in genes related to the functioning of immune system (TLR4, MMP9, E-selectin, IL-1 beta and TNF-alpha). Single nucleotide genetic polymorphisms do not constitute a modifiable risk. This indicates that, at least in part, susceptibility to recurrent aphthous stomatitis is hereditary, and that these factors cannot be modified.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.39 n.4 20212021-08-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000401102en10.4067/S0717-95022021000401102
institution SCIELO
collection OJS
country Chile
countrycode CL
component Revista
access En linea
databasecode rev-scielo-cl
tag revista
region America del Sur
libraryname SciELO
language English
format Digital
author Rivera,César
Muñoz,Antonieta
Puentes,Carolina
Aguayo,Esteban
spellingShingle Rivera,César
Muñoz,Antonieta
Puentes,Carolina
Aguayo,Esteban
Risk Factors for Recurrent Aphthous Stomatitis: A Systematic Review
author_facet Rivera,César
Muñoz,Antonieta
Puentes,Carolina
Aguayo,Esteban
author_sort Rivera,César
title Risk Factors for Recurrent Aphthous Stomatitis: A Systematic Review
title_short Risk Factors for Recurrent Aphthous Stomatitis: A Systematic Review
title_full Risk Factors for Recurrent Aphthous Stomatitis: A Systematic Review
title_fullStr Risk Factors for Recurrent Aphthous Stomatitis: A Systematic Review
title_full_unstemmed Risk Factors for Recurrent Aphthous Stomatitis: A Systematic Review
title_sort risk factors for recurrent aphthous stomatitis: a systematic review
description SUMMARY: The cause and prevention of recurrent aphthous stomatitis (also called aphthous ulcers or canker sores) are still unknown. This may be due in part to ignorance of the risk factors present in susceptible people. In this systematic review (PROSPERO record #CRD42019122214), we show that most of the risk factors for the disease are single nucleotide genetic polymorphisms in genes related to the functioning of immune system (TLR4, MMP9, E-selectin, IL-1 beta and TNF-alpha). Single nucleotide genetic polymorphisms do not constitute a modifiable risk. This indicates that, at least in part, susceptibility to recurrent aphthous stomatitis is hereditary, and that these factors cannot be modified.
publisher Sociedad Chilena de Anatomía
publishDate 2021
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000401102
work_keys_str_mv AT riveracesar riskfactorsforrecurrentaphthousstomatitisasystematicreview
AT munozantonieta riskfactorsforrecurrentaphthousstomatitisasystematicreview
AT puentescarolina riskfactorsforrecurrentaphthousstomatitisasystematicreview
AT aguayoesteban riskfactorsforrecurrentaphthousstomatitisasystematicreview
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