Death-Associated Protein Kinase is Underexpressed in High-Grade Oral Squamous Cell Carcinoma
An immunohistochemical analysis of 40 cases of oral squamous cell carcinoma was performed to evaluate the relationship between the expression pattern of death-associated protein kinase (DAPk) positive cells with the histological malignancy grading of these lesions. According to our results, eleven cases (27.5%) were high-grade malignancy tumours and 29 (72.5%) were low-grade ones. We found that 92.86% of the low-grade tumours were positive to anti-DAP kinase antibody whereas only 7.14% of the high-grade tumours presented positivity, and this difference was statistically significant (p<0.01). Sixteen (55.2%) of the low-grade carcinomas exhibited moderate immunoreactivity whereas ten cases (34.5%) showed weak staining and three cases (10.3%) were negative tumours. Immunostaining was lacking in nine (81.8%) of the high-grade carcinomas and "weak" in the two (18.2%) remaining cases. Thus, DAPk expression is significantly decreased in high-grade oral carcinomas, and evidences indicate that it might be related to the severity of cytological atypia.
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Digital revista |
| Language: | English |
| Published: |
Sociedad Chilena de Anatomía
2010
|
| Online Access: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000200044 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| id |
oai:scielo:S0717-95022010000200044 |
|---|---|
| record_format |
ojs |
| spelling |
oai:scielo:S0717-950220100002000442010-10-21Death-Associated Protein Kinase is Underexpressed in High-Grade Oral Squamous Cell CarcinomaMeneses,Ismário Silva deSouza,Rafael Reis deJeraldo,Verónica de Lourdes SierpeCavalcante,Danielle Rodrigues RibeiroReis,Francisco PradoAlbuquerque Júnior,Ricardo Luiz Cavalcanti de Immunohistochemistry DAP kinase Apoptosis Squamous cell carcinoma An immunohistochemical analysis of 40 cases of oral squamous cell carcinoma was performed to evaluate the relationship between the expression pattern of death-associated protein kinase (DAPk) positive cells with the histological malignancy grading of these lesions. According to our results, eleven cases (27.5%) were high-grade malignancy tumours and 29 (72.5%) were low-grade ones. We found that 92.86% of the low-grade tumours were positive to anti-DAP kinase antibody whereas only 7.14% of the high-grade tumours presented positivity, and this difference was statistically significant (p<0.01). Sixteen (55.2%) of the low-grade carcinomas exhibited moderate immunoreactivity whereas ten cases (34.5%) showed weak staining and three cases (10.3%) were negative tumours. Immunostaining was lacking in nine (81.8%) of the high-grade carcinomas and "weak" in the two (18.2%) remaining cases. Thus, DAPk expression is significantly decreased in high-grade oral carcinomas, and evidences indicate that it might be related to the severity of cytological atypia.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.28 n.2 20102010-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000200044en10.4067/S0717-95022010000200044 |
| institution |
SCIELO |
| collection |
OJS |
| country |
Chile |
| countrycode |
CL |
| component |
Revista |
| access |
En linea |
| databasecode |
rev-scielo-cl |
| tag |
revista |
| region |
America del Sur |
| libraryname |
SciELO |
| language |
English |
| format |
Digital |
| author |
Meneses,Ismário Silva de Souza,Rafael Reis de Jeraldo,Verónica de Lourdes Sierpe Cavalcante,Danielle Rodrigues Ribeiro Reis,Francisco Prado Albuquerque Júnior,Ricardo Luiz Cavalcanti de |
| spellingShingle |
Meneses,Ismário Silva de Souza,Rafael Reis de Jeraldo,Verónica de Lourdes Sierpe Cavalcante,Danielle Rodrigues Ribeiro Reis,Francisco Prado Albuquerque Júnior,Ricardo Luiz Cavalcanti de Death-Associated Protein Kinase is Underexpressed in High-Grade Oral Squamous Cell Carcinoma |
| author_facet |
Meneses,Ismário Silva de Souza,Rafael Reis de Jeraldo,Verónica de Lourdes Sierpe Cavalcante,Danielle Rodrigues Ribeiro Reis,Francisco Prado Albuquerque Júnior,Ricardo Luiz Cavalcanti de |
| author_sort |
Meneses,Ismário Silva de |
| title |
Death-Associated Protein Kinase is Underexpressed in High-Grade Oral Squamous Cell Carcinoma |
| title_short |
Death-Associated Protein Kinase is Underexpressed in High-Grade Oral Squamous Cell Carcinoma |
| title_full |
Death-Associated Protein Kinase is Underexpressed in High-Grade Oral Squamous Cell Carcinoma |
| title_fullStr |
Death-Associated Protein Kinase is Underexpressed in High-Grade Oral Squamous Cell Carcinoma |
| title_full_unstemmed |
Death-Associated Protein Kinase is Underexpressed in High-Grade Oral Squamous Cell Carcinoma |
| title_sort |
death-associated protein kinase is underexpressed in high-grade oral squamous cell carcinoma |
| description |
An immunohistochemical analysis of 40 cases of oral squamous cell carcinoma was performed to evaluate the relationship between the expression pattern of death-associated protein kinase (DAPk) positive cells with the histological malignancy grading of these lesions. According to our results, eleven cases (27.5%) were high-grade malignancy tumours and 29 (72.5%) were low-grade ones. We found that 92.86% of the low-grade tumours were positive to anti-DAP kinase antibody whereas only 7.14% of the high-grade tumours presented positivity, and this difference was statistically significant (p<0.01). Sixteen (55.2%) of the low-grade carcinomas exhibited moderate immunoreactivity whereas ten cases (34.5%) showed weak staining and three cases (10.3%) were negative tumours. Immunostaining was lacking in nine (81.8%) of the high-grade carcinomas and "weak" in the two (18.2%) remaining cases. Thus, DAPk expression is significantly decreased in high-grade oral carcinomas, and evidences indicate that it might be related to the severity of cytological atypia. |
| publisher |
Sociedad Chilena de Anatomía |
| publishDate |
2010 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000200044 |
| work_keys_str_mv |
AT menesesismariosilvade deathassociatedproteinkinaseisunderexpressedinhighgradeoralsquamouscellcarcinoma AT souzarafaelreisde deathassociatedproteinkinaseisunderexpressedinhighgradeoralsquamouscellcarcinoma AT jeraldoveronicadelourdessierpe deathassociatedproteinkinaseisunderexpressedinhighgradeoralsquamouscellcarcinoma AT cavalcantedaniellerodriguesribeiro deathassociatedproteinkinaseisunderexpressedinhighgradeoralsquamouscellcarcinoma AT reisfranciscoprado deathassociatedproteinkinaseisunderexpressedinhighgradeoralsquamouscellcarcinoma AT albuquerquejuniorricardoluizcavalcantide deathassociatedproteinkinaseisunderexpressedinhighgradeoralsquamouscellcarcinoma |
| _version_ |
1755992887932223488 |