The effect of Vitamin E supplementation on inflammatory biomarkers and oxidative stress in patients with chronic kidney disease on hemodialysis: A systematic review

ABSTRACT Hemodialysis, along with chronic kidney disease (CKD), intensifies the inflammatory process and oxidative stress in patients undergoing treatment. In this context, Vitamin E supplementation can mitigate the deleterious effects resulting from these processes. This is a systematic review whose objective was to evaluate the effect of Vitamin E supplementation on inflammatory biomarkers and oxidative stress in patients with CKD on hemodialysis. This review was prepared according to the methodology for systematic reviews and meta-analyses (PRISMA) and the search was performed in Pubmed, Cochrane Library, Scopus and Web of Science databases. The risk of bias of the included studies was assessed with the Cochrane Risk of Bias Tool. Twelve studies developed between 2006 and 2020 were included in this review. Most of them (n= 11) used vitamin E doses ranging from 400 IU to 888 IU and the supplementation time ranged from 2 weeks to 12 months. Of all the 12 articles included, 25% (n= 3) analyzed supplementation on biomarkers of oxidative stress and 25% (n= 3) addressed these parameters simultaneously. A positive effect was observed in 58.4% of the studies (n= 7). Thus, Vitamin E supplementation can be effective in mitigating the inflammatory process and oxidative stress, however, it is worth noting that the effect depends on the dose and time of supplementation.

Bibliographic Details

Main Authors:	Morais de Sousa,Dallyla Jennifer, Cardoso de Sousa,Larissa Layana, Oliveira Barrense,Clenio, Cardoso de Araújo,Diana Stefany, Visgueira de Sousa,Thayanne Gabryelle, de Azevedo Paiva,Adriana, Silva de Almendra Freitas,Betânia de Jesus e
Format:	Digital revista
Language:	English
Published:	Sociedad Chilena de Nutrición, Bromatología y Toxicología 2023
Online Access:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-75182023000100117
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