Mild poikilocapnic hypoxia increases very low frequency haemoglobin oxygenation oscillations in prefrontal cortex
Abstract Background: The aim of the study was to investigate the effect of mild cerebral hypoxia on haemoglobin oxygenation (HbO2), cerebrospinal fluid dynamics and cardiovascular physiology. To achieve this goal, four signals were recorded simultaneously: blood pressure, heart rate / electrocardiogram, HbO2 from right hemisphere and changes of subarachnoid space (SAS) width from left hemisphere. Signals were registered from 30 healthy, young participants (2 females and 28 males, body mass index = 24.5 ± 2.3 kg/m2, age 30.8 ± 13.4 years). Results: We analysed the recorded signals using wavelet transform and phase coherence. We demonstrated for the first time that in healthy subjects exposed to mild poikilokapnic hypoxia there were increases in very low frequency HbO2 oscillations (< 0.052 Hz) in prefrontal cortex. Additionally, SAS fluctuation diminished in the whole frequency range which could be explained by brain oedema. Conclusions: Consequently the study provides insight into mechanisms governing brain response to a mild hypoxic challenge. Our study supports the notion that HbO2 and SAS width monitoring might be beneficial for patients with acute lung disease.
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Sociedad de Biología de Chile
2021
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oai:scielo:S0716-976020210001002312022-03-28Mild poikilocapnic hypoxia increases very low frequency haemoglobin oxygenation oscillations in prefrontal cortexGruszecka,AgnieszkaWaskow,MonikaMalkiewicz,Marta A.Neary,J. PatrickSingh,JyotpalTeckchandani,TaylorKratzig,Gregory PWszedybyl-Winklewska,MagdalenaFrydrychowski,Andrzej F.Rumiński,JacekGtowacka,NataliaLass,PiotrWinklewski,Pawel J.Gruszecki,Marcin Hypoxia Wavelet transform Blood pressure Subarachnoid space width Near infrared spectroscopy Abstract Background: The aim of the study was to investigate the effect of mild cerebral hypoxia on haemoglobin oxygenation (HbO2), cerebrospinal fluid dynamics and cardiovascular physiology. To achieve this goal, four signals were recorded simultaneously: blood pressure, heart rate / electrocardiogram, HbO2 from right hemisphere and changes of subarachnoid space (SAS) width from left hemisphere. Signals were registered from 30 healthy, young participants (2 females and 28 males, body mass index = 24.5 ± 2.3 kg/m2, age 30.8 ± 13.4 years). Results: We analysed the recorded signals using wavelet transform and phase coherence. We demonstrated for the first time that in healthy subjects exposed to mild poikilokapnic hypoxia there were increases in very low frequency HbO2 oscillations (< 0.052 Hz) in prefrontal cortex. Additionally, SAS fluctuation diminished in the whole frequency range which could be explained by brain oedema. Conclusions: Consequently the study provides insight into mechanisms governing brain response to a mild hypoxic challenge. Our study supports the notion that HbO2 and SAS width monitoring might be beneficial for patients with acute lung disease.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.54 20212021-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602021000100231en10.1186/s40659-021-00362-2 |
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Gruszecka,Agnieszka Waskow,Monika Malkiewicz,Marta A. Neary,J. Patrick Singh,Jyotpal Teckchandani,Taylor Kratzig,Gregory P Wszedybyl-Winklewska,Magdalena Frydrychowski,Andrzej F. Rumiński,Jacek Gtowacka,Natalia Lass,Piotr Winklewski,Pawel J. Gruszecki,Marcin |
| spellingShingle |
Gruszecka,Agnieszka Waskow,Monika Malkiewicz,Marta A. Neary,J. Patrick Singh,Jyotpal Teckchandani,Taylor Kratzig,Gregory P Wszedybyl-Winklewska,Magdalena Frydrychowski,Andrzej F. Rumiński,Jacek Gtowacka,Natalia Lass,Piotr Winklewski,Pawel J. Gruszecki,Marcin Mild poikilocapnic hypoxia increases very low frequency haemoglobin oxygenation oscillations in prefrontal cortex |
| author_facet |
Gruszecka,Agnieszka Waskow,Monika Malkiewicz,Marta A. Neary,J. Patrick Singh,Jyotpal Teckchandani,Taylor Kratzig,Gregory P Wszedybyl-Winklewska,Magdalena Frydrychowski,Andrzej F. Rumiński,Jacek Gtowacka,Natalia Lass,Piotr Winklewski,Pawel J. Gruszecki,Marcin |
| author_sort |
Gruszecka,Agnieszka |
| title |
Mild poikilocapnic hypoxia increases very low frequency haemoglobin oxygenation oscillations in prefrontal cortex |
| title_short |
Mild poikilocapnic hypoxia increases very low frequency haemoglobin oxygenation oscillations in prefrontal cortex |
| title_full |
Mild poikilocapnic hypoxia increases very low frequency haemoglobin oxygenation oscillations in prefrontal cortex |
| title_fullStr |
Mild poikilocapnic hypoxia increases very low frequency haemoglobin oxygenation oscillations in prefrontal cortex |
| title_full_unstemmed |
Mild poikilocapnic hypoxia increases very low frequency haemoglobin oxygenation oscillations in prefrontal cortex |
| title_sort |
mild poikilocapnic hypoxia increases very low frequency haemoglobin oxygenation oscillations in prefrontal cortex |
| description |
Abstract Background: The aim of the study was to investigate the effect of mild cerebral hypoxia on haemoglobin oxygenation (HbO2), cerebrospinal fluid dynamics and cardiovascular physiology. To achieve this goal, four signals were recorded simultaneously: blood pressure, heart rate / electrocardiogram, HbO2 from right hemisphere and changes of subarachnoid space (SAS) width from left hemisphere. Signals were registered from 30 healthy, young participants (2 females and 28 males, body mass index = 24.5 ± 2.3 kg/m2, age 30.8 ± 13.4 years). Results: We analysed the recorded signals using wavelet transform and phase coherence. We demonstrated for the first time that in healthy subjects exposed to mild poikilokapnic hypoxia there were increases in very low frequency HbO2 oscillations (< 0.052 Hz) in prefrontal cortex. Additionally, SAS fluctuation diminished in the whole frequency range which could be explained by brain oedema. Conclusions: Consequently the study provides insight into mechanisms governing brain response to a mild hypoxic challenge. Our study supports the notion that HbO2 and SAS width monitoring might be beneficial for patients with acute lung disease. |
| publisher |
Sociedad de Biología de Chile |
| publishDate |
2021 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602021000100231 |
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1755990980299849728 |